Sonic Hedgehog signaling in oligodendrogenesis, myelination, demyelinating diseases, and remyelination

The Hedgehog (HH) family includes Indian (IHH), Desert (DHH), and Sonic Hedgehog (SHH). HH signaling plays a crucial role in myelination and oligodendrocyte lineage development. SHH regulates the specification, proliferation, and migration of oligodendrocyte precursor cells (OPCs), being essential f...

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Authors: Marchena-Fernández, Miguel, Sánchez-Camacho Blázquez, Cristina, Muñoz-Sáez, Emma, Macías-Castellano, Alba, Castro Soubriet, Fernando de
Format: article
Publication Date:2025
Country:España
Institution:Universidad Complutense de Madrid (UCM)
Repository:Docta Complutense
Language:English
OAI Identifier:oai:docta.ucm.es:20.500.14352/125270
Online Access:https://hdl.handle.net/20.500.14352/125270
Access Level:Open access
Keyword:612.82
Neurociencias (Biológicas)
Fisiología animal (Biología)
Biología celular (Biología)
2407.04 Citología
2411.11 Neurofisiología
2490 Neurociencias
3205.07 Neurología
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oai_identifier_str oai:docta.ucm.es:20.500.14352/125270
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spelling Sonic Hedgehog signaling in oligodendrogenesis, myelination, demyelinating diseases, and remyelinationMarchena-Fernández, MiguelSánchez-Camacho Blázquez, CristinaMuñoz-Sáez, EmmaMacías-Castellano, AlbaCastro Soubriet, Fernando de612.82Neurociencias (Biológicas)Fisiología animal (Biología)Biología celular (Biología)2407.04 Citología2411.11 Neurofisiología2490 Neurociencias3205.07 NeurologíaThe Hedgehog (HH) family includes Indian (IHH), Desert (DHH), and Sonic Hedgehog (SHH). HH signaling plays a crucial role in myelination and oligodendrocyte lineage development. SHH regulates the specification, proliferation, and migration of oligodendrocyte precursor cells (OPCs), being essential for myelin production and remyelination. The balance of SHH/SMO signaling affects both oligodendrocyte differentiation and demyelinating disease progression. Understanding this pathway may open new therapeutic strategies for multiple sclerosis and leukodystrophies.Wolters Kluwer Medknow PublicationsUniversidad Complutense de Madrid20252025-08-1320252025-08-13journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/125270reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)InglésengAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023 PID2022-143110OB-I00 (RE)MIELINIZACION EN ESCLEROSIS MULTIPLE Y LEUCODISTROFIAS DESMIELINIZANTES RARAS: DESARROLLO DE MODELOS DE ENFERMEDAD IN VITRO E IN VIVO PARA CONSEGUIR PRODUCIR MIELINAopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1252702026-06-02T12:44:21Z
dc.title.none.fl_str_mv Sonic Hedgehog signaling in oligodendrogenesis, myelination, demyelinating diseases, and remyelination
title Sonic Hedgehog signaling in oligodendrogenesis, myelination, demyelinating diseases, and remyelination
spellingShingle Sonic Hedgehog signaling in oligodendrogenesis, myelination, demyelinating diseases, and remyelination
Marchena-Fernández, Miguel
612.82
Neurociencias (Biológicas)
Fisiología animal (Biología)
Biología celular (Biología)
2407.04 Citología
2411.11 Neurofisiología
2490 Neurociencias
3205.07 Neurología
title_short Sonic Hedgehog signaling in oligodendrogenesis, myelination, demyelinating diseases, and remyelination
title_full Sonic Hedgehog signaling in oligodendrogenesis, myelination, demyelinating diseases, and remyelination
title_fullStr Sonic Hedgehog signaling in oligodendrogenesis, myelination, demyelinating diseases, and remyelination
title_full_unstemmed Sonic Hedgehog signaling in oligodendrogenesis, myelination, demyelinating diseases, and remyelination
title_sort Sonic Hedgehog signaling in oligodendrogenesis, myelination, demyelinating diseases, and remyelination
dc.creator.none.fl_str_mv Marchena-Fernández, Miguel
Sánchez-Camacho Blázquez, Cristina
Muñoz-Sáez, Emma
Macías-Castellano, Alba
Castro Soubriet, Fernando de
author Marchena-Fernández, Miguel
author_facet Marchena-Fernández, Miguel
Sánchez-Camacho Blázquez, Cristina
Muñoz-Sáez, Emma
Macías-Castellano, Alba
Castro Soubriet, Fernando de
author_role author
author2 Sánchez-Camacho Blázquez, Cristina
Muñoz-Sáez, Emma
Macías-Castellano, Alba
Castro Soubriet, Fernando de
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 612.82
Neurociencias (Biológicas)
Fisiología animal (Biología)
Biología celular (Biología)
2407.04 Citología
2411.11 Neurofisiología
2490 Neurociencias
3205.07 Neurología
topic 612.82
Neurociencias (Biológicas)
Fisiología animal (Biología)
Biología celular (Biología)
2407.04 Citología
2411.11 Neurofisiología
2490 Neurociencias
3205.07 Neurología
description The Hedgehog (HH) family includes Indian (IHH), Desert (DHH), and Sonic Hedgehog (SHH). HH signaling plays a crucial role in myelination and oligodendrocyte lineage development. SHH regulates the specification, proliferation, and migration of oligodendrocyte precursor cells (OPCs), being essential for myelin production and remyelination. The balance of SHH/SMO signaling affects both oligodendrocyte differentiation and demyelinating disease progression. Understanding this pathway may open new therapeutic strategies for multiple sclerosis and leukodystrophies.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-08-13
2025
2025-08-13
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/125270
url https://hdl.handle.net/20.500.14352/125270
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023 PID2022-143110OB-I00 (RE)MIELINIZACION EN ESCLEROSIS MULTIPLE Y LEUCODISTROFIAS DESMIELINIZANTES RARAS: DESARROLLO DE MODELOS DE ENFERMEDAD IN VITRO E IN VIVO PARA CONSEGUIR PRODUCIR MIELINA
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wolters Kluwer Medknow Publications
publisher.none.fl_str_mv Wolters Kluwer Medknow Publications
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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