Acridine and quindoline oligomers linked through a 4-aminoproline backbone prefer G-quadruplex structures

[Background] DNA-intercalating drugs are planar molecules with several fused aromatic rings that form stacks between DNA base pairs, reducing the opening and unwinding of the double helix. Recently, interest on intercalating agents has moved in the search for new ligands to G-quadruplex structures.

Detalles Bibliográficos
Autores: Ferreira, Rubén, Artali, Roberto, Farrera-Sinfreu, Josep, Albericio, Fernando, Royo, Miriam, Eritja Casadellà, Ramón, Mazzini, Stefania
Tipo de recurso: artículo
Fecha de publicación:2011
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/46789
Acceso en línea:http://hdl.handle.net/10261/46789
Access Level:acceso abierto
Palabra clave:Oligonucleotides
Acridine
Quindoline
G-quadruplex
NMR
DNA-binding drugs
Descripción
Sumario:[Background] DNA-intercalating drugs are planar molecules with several fused aromatic rings that form stacks between DNA base pairs, reducing the opening and unwinding of the double helix. Recently, interest on intercalating agents has moved in the search for new ligands to G-quadruplex structures.

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