Cross-sectional evaluation of circulating hepatitis B virus RNA and DNA
Different forms of pregenomic and other hepatitis B virus (HBV) RNA have been detected in patients' sera. These circulating HBV-RNAs may be useful for monitoring covalently closed circular DNA activity, and predicting hepatitis B e-antigen seroconversion or viral rebound after nucleos(t)ide ana...
| Autores: | , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Recursos: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:282997 |
| Acesso em linha: | https://ddd.uab.cat/record/282997 https://dx.doi.org/urn:doi:10.3748/wjg.v27.i41.7144 |
| Access Level: | acceso abierto |
| Palavra-chave: | Hepatitis B virus RNA Hepatitis B X gene Quasispecies Next-generation sequencing Quasispecies conservation Quasispecies complexity |
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Cross-sectional evaluation of circulating hepatitis B virus RNA and DNADifferent quasispecies?García-García, Selene|||0000-0001-7697-2058Cortese, Maria Francesca|||0000-0002-4318-532XTabernero, David|||0000-0002-1146-4084Gregori i Font, Josep|||0000-0002-4253-8015Vila, Marta|||0000-0001-9303-5189Pacín Ruiz, Beatriz|||0000-0001-8718-6589Quer, Josep|||0000-0003-0014-084XCasillas, Rosario|||0000-0002-6758-6734Castillo-Ribelles, Laura|||0000-0001-9380-7839Ferrer Costa, Roser|||0000-0002-8925-3172Rando-Segura, Ariadna|||0000-0003-4555-7286Trejo-Zahínos, JesúsPumarola Suñé, Tomàs|||0000-0002-5171-7461Casis-Saez, ErnestoEsteban, Rafael|||0000-0001-5280-392XRiveiro Barciela, Mar|||0000-0001-9309-2052Buti, Maria|||0000-0002-0732-3078Rodríguez Frías, Francisco|||0000-0002-9128-7013Hepatitis B virus RNAHepatitis B X geneQuasispeciesNext-generation sequencingQuasispecies conservationQuasispecies complexityDifferent forms of pregenomic and other hepatitis B virus (HBV) RNA have been detected in patients' sera. These circulating HBV-RNAs may be useful for monitoring covalently closed circular DNA activity, and predicting hepatitis B e-antigen seroconversion or viral rebound after nucleos(t)ide analog cessation. Data on serum HBV-RNA quasispecies, however, is scarce. It is therefore important to develop methodologies to thoroughly analyze this quasispecies, ensuring the elimination of any residual HBV-DNA. Studying circulating HBV-RNA quasispecies may facilitate achieving functional cure of HBV infection. To establish a next-generation sequencing (NGS) methodology for analyzing serum HBV-RNA and comparing it with DNA quasispecies. Thirteen untreated chronic hepatitis B patients, showing different HBV-genotypes and degrees of severity of liver disease were enrolled in the study and a serum sample with HBV-DNA.Universitat Autònoma de Barcelona 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/282997https://dx.doi.org/urn:doi:10.3748/wjg.v27.i41.7144reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/01436open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2829972026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Cross-sectional evaluation of circulating hepatitis B virus RNA and DNA Different quasispecies? |
| title |
Cross-sectional evaluation of circulating hepatitis B virus RNA and DNA |
| spellingShingle |
Cross-sectional evaluation of circulating hepatitis B virus RNA and DNA García-García, Selene|||0000-0001-7697-2058 Hepatitis B virus RNA Hepatitis B X gene Quasispecies Next-generation sequencing Quasispecies conservation Quasispecies complexity |
| title_short |
Cross-sectional evaluation of circulating hepatitis B virus RNA and DNA |
| title_full |
Cross-sectional evaluation of circulating hepatitis B virus RNA and DNA |
| title_fullStr |
Cross-sectional evaluation of circulating hepatitis B virus RNA and DNA |
| title_full_unstemmed |
Cross-sectional evaluation of circulating hepatitis B virus RNA and DNA |
| title_sort |
Cross-sectional evaluation of circulating hepatitis B virus RNA and DNA |
| dc.creator.none.fl_str_mv |
García-García, Selene|||0000-0001-7697-2058 Cortese, Maria Francesca|||0000-0002-4318-532X Tabernero, David|||0000-0002-1146-4084 Gregori i Font, Josep|||0000-0002-4253-8015 Vila, Marta|||0000-0001-9303-5189 Pacín Ruiz, Beatriz|||0000-0001-8718-6589 Quer, Josep|||0000-0003-0014-084X Casillas, Rosario|||0000-0002-6758-6734 Castillo-Ribelles, Laura|||0000-0001-9380-7839 Ferrer Costa, Roser|||0000-0002-8925-3172 Rando-Segura, Ariadna|||0000-0003-4555-7286 Trejo-Zahínos, Jesús Pumarola Suñé, Tomàs|||0000-0002-5171-7461 Casis-Saez, Ernesto Esteban, Rafael|||0000-0001-5280-392X Riveiro Barciela, Mar|||0000-0001-9309-2052 Buti, Maria|||0000-0002-0732-3078 Rodríguez Frías, Francisco|||0000-0002-9128-7013 |
| author |
García-García, Selene|||0000-0001-7697-2058 |
| author_facet |
García-García, Selene|||0000-0001-7697-2058 Cortese, Maria Francesca|||0000-0002-4318-532X Tabernero, David|||0000-0002-1146-4084 Gregori i Font, Josep|||0000-0002-4253-8015 Vila, Marta|||0000-0001-9303-5189 Pacín Ruiz, Beatriz|||0000-0001-8718-6589 Quer, Josep|||0000-0003-0014-084X Casillas, Rosario|||0000-0002-6758-6734 Castillo-Ribelles, Laura|||0000-0001-9380-7839 Ferrer Costa, Roser|||0000-0002-8925-3172 Rando-Segura, Ariadna|||0000-0003-4555-7286 Trejo-Zahínos, Jesús Pumarola Suñé, Tomàs|||0000-0002-5171-7461 Casis-Saez, Ernesto Esteban, Rafael|||0000-0001-5280-392X Riveiro Barciela, Mar|||0000-0001-9309-2052 Buti, Maria|||0000-0002-0732-3078 Rodríguez Frías, Francisco|||0000-0002-9128-7013 |
| author_role |
author |
| author2 |
Cortese, Maria Francesca|||0000-0002-4318-532X Tabernero, David|||0000-0002-1146-4084 Gregori i Font, Josep|||0000-0002-4253-8015 Vila, Marta|||0000-0001-9303-5189 Pacín Ruiz, Beatriz|||0000-0001-8718-6589 Quer, Josep|||0000-0003-0014-084X Casillas, Rosario|||0000-0002-6758-6734 Castillo-Ribelles, Laura|||0000-0001-9380-7839 Ferrer Costa, Roser|||0000-0002-8925-3172 Rando-Segura, Ariadna|||0000-0003-4555-7286 Trejo-Zahínos, Jesús Pumarola Suñé, Tomàs|||0000-0002-5171-7461 Casis-Saez, Ernesto Esteban, Rafael|||0000-0001-5280-392X Riveiro Barciela, Mar|||0000-0001-9309-2052 Buti, Maria|||0000-0002-0732-3078 Rodríguez Frías, Francisco|||0000-0002-9128-7013 |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
Hepatitis B virus RNA Hepatitis B X gene Quasispecies Next-generation sequencing Quasispecies conservation Quasispecies complexity |
| topic |
Hepatitis B virus RNA Hepatitis B X gene Quasispecies Next-generation sequencing Quasispecies conservation Quasispecies complexity |
| description |
Different forms of pregenomic and other hepatitis B virus (HBV) RNA have been detected in patients' sera. These circulating HBV-RNAs may be useful for monitoring covalently closed circular DNA activity, and predicting hepatitis B e-antigen seroconversion or viral rebound after nucleos(t)ide analog cessation. Data on serum HBV-RNA quasispecies, however, is scarce. It is therefore important to develop methodologies to thoroughly analyze this quasispecies, ensuring the elimination of any residual HBV-DNA. Studying circulating HBV-RNA quasispecies may facilitate achieving functional cure of HBV infection. To establish a next-generation sequencing (NGS) methodology for analyzing serum HBV-RNA and comparing it with DNA quasispecies. Thirteen untreated chronic hepatitis B patients, showing different HBV-genotypes and degrees of severity of liver disease were enrolled in the study and a serum sample with HBV-DNA. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2 2021-01-01 2021 2021-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/282997 https://dx.doi.org/urn:doi:10.3748/wjg.v27.i41.7144 |
| url |
https://ddd.uab.cat/record/282997 https://dx.doi.org/urn:doi:10.3748/wjg.v27.i41.7144 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/01436 |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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