Importance of interaction between the matrix effect and microbial metabolism in the bioavailability of lignans

[Backgroung] Plant-lignans are polyphenols with low bioavailability and bioactivity that are transformed by the intestinal microbiota into enterolignans. Our hypotheses are: (i) the way in which plant-lignans are ingested in the diet affects, in a decisive way, the microbial metabolism of these comp...

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Detalles Bibliográficos
Autores: Langa, Susana, Curiel, José Antonio, Ruiz de la Bastida, Ana, Peirotén, Ángela, Landete, José María
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2026
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/412974
Acceso en línea:http://hdl.handle.net/10261/412974
https://api.elsevier.com/content/abstract/scopus_id/105022307858
Access Level:acceso abierto
Palabra clave:Bioaccessibility
Bioavailability
Enterolignans
Flaxseed
Health
Microbiota
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spelling Importance of interaction between the matrix effect and microbial metabolism in the bioavailability of lignansLanga, SusanaCuriel, José AntonioRuiz de la Bastida, AnaPeirotén, ÁngelaLandete, José MaríaBioaccessibilityBioavailabilityEnterolignansFlaxseedHealthMicrobiota[Backgroung] Plant-lignans are polyphenols with low bioavailability and bioactivity that are transformed by the intestinal microbiota into enterolignans. Our hypotheses are: (i) the way in which plant-lignans are ingested in the diet affects, in a decisive way, the microbial metabolism of these compounds and (ii) an increase in lignan bioaccessibility will produce an increase in enterolignans produced by the intestinal microbiota, increasing the bioavailability of lignans ingested in the diet. Therefore, our aims were to determine how the matrix effect affects the metabolism of lignans by the intestinal microbiota and how improving the bioaccessibility of lignans ingested in the diet improves their bioavailability.[Results] Human faecal samples showed close to 50 times higher efficiency in the production of enterolactone (ENL) from secoisolariciresinol than from flaxseed extracts. ENL is the main enterolignan produced by the intestinal microbiota, and it is mainly produced from dihydroxy-ENL (DHENL) via hydroxy-ENL (HENL). Moreover, the human faecal samples were able to hydrogenate and hydroxylate the ENL. On the other hand, the fermentation of a lignan-enriched food by Bifidobacterium pseudocatenulatum INIA P815 increased the concentration of lignans in the plasma and liver of mice that consumed a diet rich in lignans. DHENL, HENL and ENL showed the highest bioavailability.[Conclusion] The matrix effect is a determining factor in the bioaccessibility and the efficiency of transformation of lignans into enterolignans by the intestinal microbiota. The reduction of the matrix effect increases the production of enterolignans (DHENL, HENL and ENL) by the intestinal microbiota, increasing the bioavailability of ingested lignans. © 2025 The Author(s). Journal of the Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.Project PID2020-119630RB-I00 from the Spanish Ministry of Science and Innovation provided funding for this work. Pre-doctoral contract (PRE2018-086293) awarded to ARdlB. We are appreciative of the mass spectrometry and chromatography facilities provided by the Analysis Services Unit of the ICTAN (CSIC, Madrid, Spain).Peer reviewedWiley-VCHSociety of Chemical IndustryAgencia Estatal de Investigación (España)Ministerio de Ciencia e Innovación (España)CSIC - Instituto de Ciencia y Tecnología de Alimentos y Nutrición (ICTAN)Langa, Susana [0000-0003-2729-219X]Curiel, José Antonio [0000-0002-0111-1437]Ruiz de la Bastida, Ana [0000-0002-0650-7326]Peirotén, Ángela [0000-0002-1532-8530]Landete, José María [0000-0002-5147-3989]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202620262026info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/412974https://api.elsevier.com/content/abstract/scopus_id/105022307858reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-119630RB-I00The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.1002/jsfa.70324https://doi.org/10.1002/jsfa.70324Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4129742026-05-22T06:33:51Z
dc.title.none.fl_str_mv Importance of interaction between the matrix effect and microbial metabolism in the bioavailability of lignans
title Importance of interaction between the matrix effect and microbial metabolism in the bioavailability of lignans
spellingShingle Importance of interaction between the matrix effect and microbial metabolism in the bioavailability of lignans
Langa, Susana
Bioaccessibility
Bioavailability
Enterolignans
Flaxseed
Health
Microbiota
title_short Importance of interaction between the matrix effect and microbial metabolism in the bioavailability of lignans
title_full Importance of interaction between the matrix effect and microbial metabolism in the bioavailability of lignans
title_fullStr Importance of interaction between the matrix effect and microbial metabolism in the bioavailability of lignans
title_full_unstemmed Importance of interaction between the matrix effect and microbial metabolism in the bioavailability of lignans
title_sort Importance of interaction between the matrix effect and microbial metabolism in the bioavailability of lignans
dc.creator.none.fl_str_mv Langa, Susana
Curiel, José Antonio
Ruiz de la Bastida, Ana
Peirotén, Ángela
Landete, José María
author Langa, Susana
author_facet Langa, Susana
Curiel, José Antonio
Ruiz de la Bastida, Ana
Peirotén, Ángela
Landete, José María
author_role author
author2 Curiel, José Antonio
Ruiz de la Bastida, Ana
Peirotén, Ángela
Landete, José María
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Agencia Estatal de Investigación (España)
Ministerio de Ciencia e Innovación (España)
CSIC - Instituto de Ciencia y Tecnología de Alimentos y Nutrición (ICTAN)
Langa, Susana [0000-0003-2729-219X]
Curiel, José Antonio [0000-0002-0111-1437]
Ruiz de la Bastida, Ana [0000-0002-0650-7326]
Peirotén, Ángela [0000-0002-1532-8530]
Landete, José María [0000-0002-5147-3989]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Bioaccessibility
Bioavailability
Enterolignans
Flaxseed
Health
Microbiota
topic Bioaccessibility
Bioavailability
Enterolignans
Flaxseed
Health
Microbiota
description [Backgroung] Plant-lignans are polyphenols with low bioavailability and bioactivity that are transformed by the intestinal microbiota into enterolignans. Our hypotheses are: (i) the way in which plant-lignans are ingested in the diet affects, in a decisive way, the microbial metabolism of these compounds and (ii) an increase in lignan bioaccessibility will produce an increase in enterolignans produced by the intestinal microbiota, increasing the bioavailability of lignans ingested in the diet. Therefore, our aims were to determine how the matrix effect affects the metabolism of lignans by the intestinal microbiota and how improving the bioaccessibility of lignans ingested in the diet improves their bioavailability.
publishDate 2026
dc.date.none.fl_str_mv 2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/412974
https://api.elsevier.com/content/abstract/scopus_id/105022307858
url http://hdl.handle.net/10261/412974
https://api.elsevier.com/content/abstract/scopus_id/105022307858
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-119630RB-I00
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.1002/jsfa.70324
https://doi.org/10.1002/jsfa.70324
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley-VCH
Society of Chemical Industry
publisher.none.fl_str_mv Wiley-VCH
Society of Chemical Industry
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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