Dietary alpha-Linolenic Acid, Marine omega-3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvencion con Dleta MEDiterranea (PREDIMED) Study

Background-Epidemiological evidence suggests a cardioprotective role of a-linolenic acid (ALA), a plant-derived x-3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine x-3 fatty acids (long-chain n-3 polyunsaturated fatty acids) intake. In persons at high cardiovascula...

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Detalles Bibliográficos
Autores: Sala-Vila, Aleix, Guasch-Ferre, Marta, Hu, Frank B, Sanchez-Tainta, Ana, bullo, Monica, Serra-Mir, Merce, Lopez-Sabater, Carmen, Sorli, Jose V, Aros, Fernando, Fiol Sala, Miquel, Munoz, Miguel A, Serra-Majem, Luis, Alfredo Martinez, J, Corella, Dolores, Fito, Montserrat, Salas-Salvado, Jordi, Martinez-Gonzalez, Miguel A, Estruch, Ramon, Ros, Emilio, PREDIMED Investigators
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/20238
Acceso en línea:http://hdl.handle.net/20.500.12105/20238
Access Level:acceso abierto
Palabra clave:Fatty acid
Nutrition
Sudden cardiac death
Ácido alfa-Linolénico
Modelos de Riesgos Proporcionales
Alimentos Marinos
Ácidos Grasos Omega-3
Femenino
Dieta
Conducta de Reducción del Riesgo
Masculino
Factores Protectores
Estudios Longitudinales
Persona de Mediana Edad
Estudios Prospectivos
Medición de Riesgo
Enfermedades Cardiovasculares
Distribución de Chi-Cuadrado
Factores de Tiempo
Análisis Multivariante
Valor Nutritivo
Aceite de Oliva
Juglans
Factores de Riesgo
Humanos
Nueces
Anciano
Anciano de 80 o más Años
España
Descripción
Sumario:Background-Epidemiological evidence suggests a cardioprotective role of a-linolenic acid (ALA), a plant-derived x-3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine x-3 fatty acids (long-chain n-3 polyunsaturated fatty acids) intake. In persons at high cardiovascular risk from Spain, a country in which fish consumption is customarily high, we investigated whether meeting the International Society for the Study of Fatty Acids and Lipids recommendation for dietary ALA (0.7% of total energy) at baseline was related to all-cause and cardiovascular disease mortality. We also examined the effect of meeting the society's recommendation for long-chain n-3 polyunsaturated fatty acids (>= 500 mg/day). Methods and Results-We longitudinally evaluated 7202 participants in the PREvencion con DIeta MEDiterranea (PREDIMED) trial. Multivariable-adjusted Cox regressionmodels were fitted to estimate hazard ratios. ALA intake correlated towalnut consumption (r= 0.94). During a 5.9-y follow-up, 431 deaths occurred (104 cardiovascular disease, 55 coronary heart disease, 32 sudden cardiac death, 25 stroke). The hazard ratios formeeting ALArecommendation (n= 1615, 22.4%) were 0.72 (95% CI 0.56-0.92) for all-causemortality and 0.95 (95% CI 0.58-1.57) for fatal cardiovascular disease. The hazard ratios formeeting the recommendation for long-chain n-3 polyunsaturated fatty acids (n= 5452, 75.7%) were 0.84 (95% CI 0.67-1.05) for all-causemortality, 0.61 (95% CI 0.39-0.96) for fatal cardiovascular disease, 0.54 (95% CI 0.29-0.99) for fatal coronary heart disease, and 0.49 (95% CI 0.22-1.01) for sudden cardiac death. The highest reduction in all-cause mortality occurred in participants meeting both recommendations (hazard ratio 0.63 [ 95% CI 0.45-0.87]). Conclusions-In participants without prior cardiovascular disease and high fish consumption, dietary ALA, supplied mainly by walnuts and olive oil, relates inversely to all-cause mortality, whereas protection from cardiac mortality is limited to fish-derived long-chain n-3 polyunsaturated fatty acids.

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