Dietary Inflammatory Index and Incidence of Cardiovascular Disease in the PREDIMED Study

Previous studies have reported an association between a more pro-inflammatory diet profile and various chronic metabolic diseases. The Dietary Inflammatory Index (DII) was used to assess the inflammatory potential of nutrients and foods in the context of a dietary pattern. We prospectively examined...

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Detalles Bibliográficos
Autores: Garcia-Arellano, Ana, Ramallal, Raul, Ruiz-Canela, Miguel, Salas-Salvado, Jordi, Corella, Dolores, Shivappa, Nitin, Schroeder, Helmut, Hebert, James R, Ros, Emilio, Gomez-Garcia, Enrique, Estruch, Ramon, Lapetra, Jose, Aros, Fernando, Fiol Sala, Miquel, Serra-Majem, Lluis, Pinto, Xavier, Babio, Nancy, Gonzalez, Jose I, Fito, Montserrat, Alfredo Martinez, J, Martinez-Gonzalez, Miguel A, PREDIMED Investigators
Tipo de recurso: artículo
Fecha de publicación:2015
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/20122
Acceso en línea:http://hdl.handle.net/20.500.12105/20122
Access Level:acceso abierto
Palabra clave:Índice de Masa Corporal
Dieta Mediterránea
Incidencia
Modelos de Riesgos Proporcionales
Resultado del Tratamiento
Femenino
Análisis Multivariante
Aceite de Oliva
Masculino
Determinación de Punto Final
Estudios de Seguimiento
Factores de Riesgo
Humanos
Persona de Mediana Edad
Nueces
Ingestión de Energía
Estudios Prospectivos
Inflamación
Anciano
Anciano de 80 o más Años
Encuestas y Cuestionarios
Enfermedades Cardiovasculares
Cardiovascular Diseases
Descripción
Sumario:Previous studies have reported an association between a more pro-inflammatory diet profile and various chronic metabolic diseases. The Dietary Inflammatory Index (DII) was used to assess the inflammatory potential of nutrients and foods in the context of a dietary pattern. We prospectively examined the association between the DII and the incidence of cardiovascular disease (CVD: myocardial infarction, stroke or cardiovascular death) in the PREDIMED (Prevencion con Dieta Mediterranea) study including 7216 high-risk participants. The DII was computed based on a validated 137-item food frequency questionnaire. Multivariate-adjusted hazard ratios (HR) and 95% confidence intervals of CVD risk were computed across quartiles of the DII where the lowest (most anti-inflammatory) quartile is the referent. Risk increased across the quartiles (i.e., with increasing inflammatory potential): HRquartile2 = 1.42 (95%CI = 0.97-2.09); HRquartile3 = 1.85 (1.27-2.71); and HRquartile4 = 1.73 (1.15-2.60). When fit as continuous the multiple-adjusted hazard ratio for each additional standard deviation of the DII was 1.22 (1.06-1.40). Our results provide direct prospective evidence that a pro-inflammatory diet is associated with a higher risk of cardiovascular clinical events.

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