Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021-2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study

Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of EV-D68 infections and its clinical impact during the fall-wi...

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Autores: Pires Simoes, Margarida, Hodcroft, Emma B, Simmonds, Peter, Albert, Jan, Alidjinou, Enagnon K, Ambert-Balay, Katia, Andrés, Cristina, Antón, Andrés, Auvray, Christelle, Bailly, Jean-Luc, Baldanti, Fausto, Bastings, Capser, Beard, Stuart, Berengua, Carla, Berginc, Natasa, Bloemen, Mandy, Blomqvist, Soile, Bosma, Froukje, Böttcher, Sindy, Bubba, Laura, Buderus, Stafan, Cabrerizo, Maria, Calvo, Cristina, Celma, Cristina, Ceriotti, Ferruccio, Clark, Gemma, Costa, Inës, Coste-Burel, Marianne, Couderé, Karen, Cremer, Jeroen, Del Cuerpo Casas, Margarita, Daehne, Theo, de Beer, Jessica, de Ceano-Vivas, Maria, De Gascun, Cillian, de Rougemont, Alexis, Dean, Jonathan, Dembinski, Jennifer L, Diedrich, Sabine, Diez-Domingo, Javier, Dillner, Lena, Dorenberg, Dagny H, Ducancelle, Alexandra, Dudman, Susanne, Dyrdak, Robert, Eis-Huebinger, Anna-Maria, Falces-Romero, Iker, Farkas, Agnes, Feeney, Susan, Fernandez-Garcia, Maria Dolores, Flipse, Jacky, Franck, Kristina T, Galli, Cristina, Garrigue, Isabelle, Geeraedts, Felix, Georgieva, Irina, Giardina, Federica, Guiomar, Raquel, Hauzenberger, Elenor, Heikens, Esther, Henquell, Cécille, Hober, Didier, Hönemann, Mario, Howson-Wells, Hannah, Hruškar, Željka, Ikonen, Niina, Imbert, Berthemarie, Jansz, Arjan R, Jeannoël, Marion, Jiřincová, Helena, Josset, Laurence, Keeren, Kathrin, Kramer-Lindhout, Naomie, Krokstad, Sidsel, Lazrek, Mouna, Le Guillou-Guillemette, Hélène, Lefeuvre, Caroline, Lind, Andreas, Lunar, Maja M, Maier, Melanie, Marque-Juillet, Stéphanie, McClure, C Patrick, McKenna, James, Meijer, Adam, Menasalvas Ruiz, Ana, Mengual-Chuliá, Beatriz, Midgley, Sofie, Mirand, Audrey, Molenkamp, Richard, Montes, Milagrosa, Moreno-Docón, Antonio, Morley, Ursula, Murk, Jean-Luc, Navascués-Ortega, Ana, Nijhuis, Roel, Nikolaeva-Glomb, Lubomira, Nordbø, Svein A, Numanovic, Sanela, Oggioni, Massimo, Oñate Vergara, Eider, Pacaud, Jordi, Pacreau, Marie L, Panning, Marcus, Pariani, Elena, Pekova, Lili, Pellegrinelli, Laura, Petrovec, Miroslav, Pietsch, Corinna, Pilorge, Léa, Piñeiro, Luis, Piralla, Antonio, Poljak, Mario, Prochazka, Birgit, Rabella, Nuria, Rahamat-Langendoen, Janette C, Rainetova, Petra, Reynders, Marijke, Riezebos-Brilman, Annelies, Roorda, Lieuwe, Savolainen-Kopra, Carita, Schuffenecker, Isabelle, Smeets, Leo C, Stoyanova, Asya, Stefic, Karl, Swanink, Caroline, Tabain, Irena, Tjhie, Jeroen, Thouault, Luc, Tumiotto, Camille, Uceda Renteria, Sara, Uršič, Tina, Vallet, Sophie, Van Ranst, Marc, Van Wunnik, Peter, Verweij, Jaco J, Vila, Jorgina, Wintermans, Bas, Wollants, Elke, Wolthers, Katja C, Xavier López-Labrador, F, Fischer, Thea Kølsen, Harvala, Heli, Benschop, Kimberley SM
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/26435
Acceso en línea:https://hdl.handle.net/20.500.12105/26435
Access Level:acceso abierto
Palabra clave:European Non-Polio Enterovirus Network (ENPEN)
Acute flaccid myelitis (AFM)
Enterovirus D68 (EV-D68)
Nonpolio enterovirus (NPEV)
Respiratory infection
Adolescent
Adult
Aged
Central Nervous System Viral Diseases
Child
Child, Preschool
Enterovirus D, Human
Enterovirus Infections
Europe
Female
Humans
Infant
Infant, Newborn
Male
Middle Aged
Myelitis
Neuromuscular Diseases
Phylogeny
Respiratory Tract Infections
Young Adult
id ES_12e305e2bd0f4ac9cf2209e8698b6f4c
oai_identifier_str oai:repisalud.isciii.es:20.500.12105/26435
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021-2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study
title Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021-2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study
spellingShingle Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021-2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study
Pires Simoes, Margarida
European Non-Polio Enterovirus Network (ENPEN)
Acute flaccid myelitis (AFM)
Enterovirus D68 (EV-D68)
Nonpolio enterovirus (NPEV)
Respiratory infection
Adolescent
Adult
Aged
Central Nervous System Viral Diseases
Child
Child, Preschool
Enterovirus D, Human
Enterovirus Infections
Europe
Female
Humans
Infant
Infant, Newborn
Male
Middle Aged
Myelitis
Neuromuscular Diseases
Phylogeny
Respiratory Tract Infections
Young Adult
title_short Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021-2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study
title_full Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021-2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study
title_fullStr Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021-2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study
title_full_unstemmed Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021-2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study
title_sort Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021-2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study
dc.creator.none.fl_str_mv Pires Simoes, Margarida
Hodcroft, Emma B
Simmonds, Peter
Albert, Jan
Alidjinou, Enagnon K
Ambert-Balay, Katia
Andrés, Cristina
Antón, Andrés
Auvray, Christelle
Bailly, Jean-Luc
Baldanti, Fausto
Bastings, Capser
Beard, Stuart
Berengua, Carla
Berginc, Natasa
Bloemen, Mandy
Blomqvist, Soile
Bosma, Froukje
Böttcher, Sindy
Bubba, Laura
Buderus, Stafan
Cabrerizo, Maria
Calvo, Cristina
Celma, Cristina
Ceriotti, Ferruccio
Clark, Gemma
Costa, Inës
Coste-Burel, Marianne
Couderé, Karen
Cremer, Jeroen
Del Cuerpo Casas, Margarita
Daehne, Theo
de Beer, Jessica
de Ceano-Vivas, Maria
De Gascun, Cillian
de Rougemont, Alexis
Dean, Jonathan
Dembinski, Jennifer L
Diedrich, Sabine
Diez-Domingo, Javier
Dillner, Lena
Dorenberg, Dagny H
Ducancelle, Alexandra
Dudman, Susanne
Dyrdak, Robert
Eis-Huebinger, Anna-Maria
Falces-Romero, Iker
Farkas, Agnes
Feeney, Susan
Fernandez-Garcia, Maria Dolores
Flipse, Jacky
Franck, Kristina T
Galli, Cristina
Garrigue, Isabelle
Geeraedts, Felix
Georgieva, Irina
Giardina, Federica
Guiomar, Raquel
Hauzenberger, Elenor
Heikens, Esther
Henquell, Cécille
Hober, Didier
Hönemann, Mario
Howson-Wells, Hannah
Hruškar, Željka
Ikonen, Niina
Imbert, Berthemarie
Jansz, Arjan R
Jeannoël, Marion
Jiřincová, Helena
Josset, Laurence
Keeren, Kathrin
Kramer-Lindhout, Naomie
Krokstad, Sidsel
Lazrek, Mouna
Le Guillou-Guillemette, Hélène
Lefeuvre, Caroline
Lind, Andreas
Lunar, Maja M
Maier, Melanie
Marque-Juillet, Stéphanie
McClure, C Patrick
McKenna, James
Meijer, Adam
Menasalvas Ruiz, Ana
Mengual-Chuliá, Beatriz
Midgley, Sofie
Mirand, Audrey
Molenkamp, Richard
Montes, Milagrosa
Moreno-Docón, Antonio
Morley, Ursula
Murk, Jean-Luc
Navascués-Ortega, Ana
Nijhuis, Roel
Nikolaeva-Glomb, Lubomira
Nordbø, Svein A
Numanovic, Sanela
Oggioni, Massimo
Oñate Vergara, Eider
Pacaud, Jordi
Pacreau, Marie L
Panning, Marcus
Pariani, Elena
Pekova, Lili
Pellegrinelli, Laura
Petrovec, Miroslav
Pietsch, Corinna
Pilorge, Léa
Piñeiro, Luis
Piralla, Antonio
Poljak, Mario
Prochazka, Birgit
Rabella, Nuria
Rahamat-Langendoen, Janette C
Rainetova, Petra
Reynders, Marijke
Riezebos-Brilman, Annelies
Roorda, Lieuwe
Savolainen-Kopra, Carita
Schuffenecker, Isabelle
Smeets, Leo C
Stoyanova, Asya
Stefic, Karl
Swanink, Caroline
Tabain, Irena
Tjhie, Jeroen
Thouault, Luc
Tumiotto, Camille
Uceda Renteria, Sara
Uršič, Tina
Vallet, Sophie
Van Ranst, Marc
Van Wunnik, Peter
Verweij, Jaco J
Vila, Jorgina
Wintermans, Bas
Wollants, Elke
Wolthers, Katja C
Xavier López-Labrador, F
Fischer, Thea Kølsen
Harvala, Heli
Benschop, Kimberley SM
author Pires Simoes, Margarida
author_facet Pires Simoes, Margarida
Hodcroft, Emma B
Simmonds, Peter
Albert, Jan
Alidjinou, Enagnon K
Ambert-Balay, Katia
Andrés, Cristina
Antón, Andrés
Auvray, Christelle
Bailly, Jean-Luc
Baldanti, Fausto
Bastings, Capser
Beard, Stuart
Berengua, Carla
Berginc, Natasa
Bloemen, Mandy
Blomqvist, Soile
Bosma, Froukje
Böttcher, Sindy
Bubba, Laura
Buderus, Stafan
Cabrerizo, Maria
Calvo, Cristina
Celma, Cristina
Ceriotti, Ferruccio
Clark, Gemma
Costa, Inës
Coste-Burel, Marianne
Couderé, Karen
Cremer, Jeroen
Del Cuerpo Casas, Margarita
Daehne, Theo
de Beer, Jessica
de Ceano-Vivas, Maria
De Gascun, Cillian
de Rougemont, Alexis
Dean, Jonathan
Dembinski, Jennifer L
Diedrich, Sabine
Diez-Domingo, Javier
Dillner, Lena
Dorenberg, Dagny H
Ducancelle, Alexandra
Dudman, Susanne
Dyrdak, Robert
Eis-Huebinger, Anna-Maria
Falces-Romero, Iker
Farkas, Agnes
Feeney, Susan
Fernandez-Garcia, Maria Dolores
Flipse, Jacky
Franck, Kristina T
Galli, Cristina
Garrigue, Isabelle
Geeraedts, Felix
Georgieva, Irina
Giardina, Federica
Guiomar, Raquel
Hauzenberger, Elenor
Heikens, Esther
Henquell, Cécille
Hober, Didier
Hönemann, Mario
Howson-Wells, Hannah
Hruškar, Željka
Ikonen, Niina
Imbert, Berthemarie
Jansz, Arjan R
Jeannoël, Marion
Jiřincová, Helena
Josset, Laurence
Keeren, Kathrin
Kramer-Lindhout, Naomie
Krokstad, Sidsel
Lazrek, Mouna
Le Guillou-Guillemette, Hélène
Lefeuvre, Caroline
Lind, Andreas
Lunar, Maja M
Maier, Melanie
Marque-Juillet, Stéphanie
McClure, C Patrick
McKenna, James
Meijer, Adam
Menasalvas Ruiz, Ana
Mengual-Chuliá, Beatriz
Midgley, Sofie
Mirand, Audrey
Molenkamp, Richard
Montes, Milagrosa
Moreno-Docón, Antonio
Morley, Ursula
Murk, Jean-Luc
Navascués-Ortega, Ana
Nijhuis, Roel
Nikolaeva-Glomb, Lubomira
Nordbø, Svein A
Numanovic, Sanela
Oggioni, Massimo
Oñate Vergara, Eider
Pacaud, Jordi
Pacreau, Marie L
Panning, Marcus
Pariani, Elena
Pekova, Lili
Pellegrinelli, Laura
Petrovec, Miroslav
Pietsch, Corinna
Pilorge, Léa
Piñeiro, Luis
Piralla, Antonio
Poljak, Mario
Prochazka, Birgit
Rabella, Nuria
Rahamat-Langendoen, Janette C
Rainetova, Petra
Reynders, Marijke
Riezebos-Brilman, Annelies
Roorda, Lieuwe
Savolainen-Kopra, Carita
Schuffenecker, Isabelle
Smeets, Leo C
Stoyanova, Asya
Stefic, Karl
Swanink, Caroline
Tabain, Irena
Tjhie, Jeroen
Thouault, Luc
Tumiotto, Camille
Uceda Renteria, Sara
Uršič, Tina
Vallet, Sophie
Van Ranst, Marc
Van Wunnik, Peter
Verweij, Jaco J
Vila, Jorgina
Wintermans, Bas
Wollants, Elke
Wolthers, Katja C
Xavier López-Labrador, F
Fischer, Thea Kølsen
Harvala, Heli
Benschop, Kimberley SM
author_role author
author2 Hodcroft, Emma B
Simmonds, Peter
Albert, Jan
Alidjinou, Enagnon K
Ambert-Balay, Katia
Andrés, Cristina
Antón, Andrés
Auvray, Christelle
Bailly, Jean-Luc
Baldanti, Fausto
Bastings, Capser
Beard, Stuart
Berengua, Carla
Berginc, Natasa
Bloemen, Mandy
Blomqvist, Soile
Bosma, Froukje
Böttcher, Sindy
Bubba, Laura
Buderus, Stafan
Cabrerizo, Maria
Calvo, Cristina
Celma, Cristina
Ceriotti, Ferruccio
Clark, Gemma
Costa, Inës
Coste-Burel, Marianne
Couderé, Karen
Cremer, Jeroen
Del Cuerpo Casas, Margarita
Daehne, Theo
de Beer, Jessica
de Ceano-Vivas, Maria
De Gascun, Cillian
de Rougemont, Alexis
Dean, Jonathan
Dembinski, Jennifer L
Diedrich, Sabine
Diez-Domingo, Javier
Dillner, Lena
Dorenberg, Dagny H
Ducancelle, Alexandra
Dudman, Susanne
Dyrdak, Robert
Eis-Huebinger, Anna-Maria
Falces-Romero, Iker
Farkas, Agnes
Feeney, Susan
Fernandez-Garcia, Maria Dolores
Flipse, Jacky
Franck, Kristina T
Galli, Cristina
Garrigue, Isabelle
Geeraedts, Felix
Georgieva, Irina
Giardina, Federica
Guiomar, Raquel
Hauzenberger, Elenor
Heikens, Esther
Henquell, Cécille
Hober, Didier
Hönemann, Mario
Howson-Wells, Hannah
Hruškar, Željka
Ikonen, Niina
Imbert, Berthemarie
Jansz, Arjan R
Jeannoël, Marion
Jiřincová, Helena
Josset, Laurence
Keeren, Kathrin
Kramer-Lindhout, Naomie
Krokstad, Sidsel
Lazrek, Mouna
Le Guillou-Guillemette, Hélène
Lefeuvre, Caroline
Lind, Andreas
Lunar, Maja M
Maier, Melanie
Marque-Juillet, Stéphanie
McClure, C Patrick
McKenna, James
Meijer, Adam
Menasalvas Ruiz, Ana
Mengual-Chuliá, Beatriz
Midgley, Sofie
Mirand, Audrey
Molenkamp, Richard
Montes, Milagrosa
Moreno-Docón, Antonio
Morley, Ursula
Murk, Jean-Luc
Navascués-Ortega, Ana
Nijhuis, Roel
Nikolaeva-Glomb, Lubomira
Nordbø, Svein A
Numanovic, Sanela
Oggioni, Massimo
Oñate Vergara, Eider
Pacaud, Jordi
Pacreau, Marie L
Panning, Marcus
Pariani, Elena
Pekova, Lili
Pellegrinelli, Laura
Petrovec, Miroslav
Pietsch, Corinna
Pilorge, Léa
Piñeiro, Luis
Piralla, Antonio
Poljak, Mario
Prochazka, Birgit
Rabella, Nuria
Rahamat-Langendoen, Janette C
Rainetova, Petra
Reynders, Marijke
Riezebos-Brilman, Annelies
Roorda, Lieuwe
Savolainen-Kopra, Carita
Schuffenecker, Isabelle
Smeets, Leo C
Stoyanova, Asya
Stefic, Karl
Swanink, Caroline
Tabain, Irena
Tjhie, Jeroen
Thouault, Luc
Tumiotto, Camille
Uceda Renteria, Sara
Uršič, Tina
Vallet, Sophie
Van Ranst, Marc
Van Wunnik, Peter
Verweij, Jaco J
Vila, Jorgina
Wintermans, Bas
Wollants, Elke
Wolthers, Katja C
Xavier López-Labrador, F
Fischer, Thea Kølsen
Harvala, Heli
Benschop, Kimberley SM
author2_role author
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dc.contributor.none.fl_str_mv Austrian Federal Ministry of Health (Austria)
Ministry of Health (República Checa)
Instituto de Salud Carlos III
Centro de Investigación Biomédica en Red - CIBERESP (Epidemiología y Salud Pública)
Santé Publique France
Unión Europea. Comisión Europea. NextGenerationEU
Ministry of Health Welfare and Sport (Países Bajos)
National Institutes of Health (Estados Unidos)
Slovenian Research Agency
Swiss National Science Foundation

dc.subject.none.fl_str_mv European Non-Polio Enterovirus Network (ENPEN)
Acute flaccid myelitis (AFM)
Enterovirus D68 (EV-D68)
Nonpolio enterovirus (NPEV)
Respiratory infection
Adolescent
Adult
Aged
Central Nervous System Viral Diseases
Child
Child, Preschool
Enterovirus D, Human
Enterovirus Infections
Europe
Female
Humans
Infant
Infant, Newborn
Male
Middle Aged
Myelitis
Neuromuscular Diseases
Phylogeny
Respiratory Tract Infections
Young Adult
topic European Non-Polio Enterovirus Network (ENPEN)
Acute flaccid myelitis (AFM)
Enterovirus D68 (EV-D68)
Nonpolio enterovirus (NPEV)
Respiratory infection
Adolescent
Adult
Aged
Central Nervous System Viral Diseases
Child
Child, Preschool
Enterovirus D, Human
Enterovirus Infections
Europe
Female
Humans
Infant
Infant, Newborn
Male
Middle Aged
Myelitis
Neuromuscular Diseases
Phylogeny
Respiratory Tract Infections
Young Adult
description Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of EV-D68 infections and its clinical impact during the fall-winter season of 2021-2022. From 19 European countries, 58 institutes reported 10 481 (6.8%) EV-positive samples of which 1004 (9.6%) were identified as EV-D68 (including 852 respiratory samples). Clinical data were reported for 969 cases; 78.9% of infections were reported in children (0-5 years); and 37.9% of cases were hospitalized. Acute respiratory distress was commonly noted (93.1%) followed by fever (49.4%). Neurological problems were observed in 6.4% of cases including 6 diagnosed with AFM. Phylodynamic/Nextstrain and phylogenetic analyses based on 694 sequences showed the emergence of 2 novel B3-derived lineages, with no regional clustering. In conclusion, we describe a large-scale European EV-D68 upsurge with severe clinical impact and the emergence of B3-derived lineages.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-10-16
2024
2024-10-16
2025
2025-03-12
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12105/26435
url https://hdl.handle.net/20.500.12105/26435
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv ES PI18CIII-00035 Not available
EC PE00000007 Not available
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021-2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre StudyPires Simoes, MargaridaHodcroft, Emma BSimmonds, PeterAlbert, JanAlidjinou, Enagnon KAmbert-Balay, KatiaAndrés, CristinaAntón, AndrésAuvray, ChristelleBailly, Jean-LucBaldanti, FaustoBastings, CapserBeard, StuartBerengua, CarlaBerginc, NatasaBloemen, MandyBlomqvist, SoileBosma, FroukjeBöttcher, SindyBubba, LauraBuderus, StafanCabrerizo, MariaCalvo, CristinaCelma, CristinaCeriotti, FerruccioClark, GemmaCosta, InësCoste-Burel, MarianneCouderé, KarenCremer, JeroenDel Cuerpo Casas, MargaritaDaehne, Theode Beer, Jessicade Ceano-Vivas, MariaDe Gascun, Cilliande Rougemont, AlexisDean, JonathanDembinski, Jennifer LDiedrich, SabineDiez-Domingo, JavierDillner, LenaDorenberg, Dagny HDucancelle, AlexandraDudman, SusanneDyrdak, RobertEis-Huebinger, Anna-MariaFalces-Romero, IkerFarkas, AgnesFeeney, SusanFernandez-Garcia, Maria DoloresFlipse, JackyFranck, Kristina TGalli, CristinaGarrigue, IsabelleGeeraedts, FelixGeorgieva, IrinaGiardina, FedericaGuiomar, RaquelHauzenberger, ElenorHeikens, EstherHenquell, CécilleHober, DidierHönemann, MarioHowson-Wells, HannahHruškar, ŽeljkaIkonen, NiinaImbert, BerthemarieJansz, Arjan RJeannoël, MarionJiřincová, HelenaJosset, LaurenceKeeren, KathrinKramer-Lindhout, NaomieKrokstad, SidselLazrek, MounaLe Guillou-Guillemette, HélèneLefeuvre, CarolineLind, AndreasLunar, Maja MMaier, MelanieMarque-Juillet, StéphanieMcClure, C PatrickMcKenna, JamesMeijer, AdamMenasalvas Ruiz, AnaMengual-Chuliá, BeatrizMidgley, SofieMirand, AudreyMolenkamp, RichardMontes, MilagrosaMoreno-Docón, AntonioMorley, UrsulaMurk, Jean-LucNavascués-Ortega, AnaNijhuis, RoelNikolaeva-Glomb, LubomiraNordbø, Svein ANumanovic, SanelaOggioni, MassimoOñate Vergara, EiderPacaud, JordiPacreau, Marie LPanning, MarcusPariani, ElenaPekova, LiliPellegrinelli, LauraPetrovec, MiroslavPietsch, CorinnaPilorge, LéaPiñeiro, LuisPiralla, AntonioPoljak, MarioProchazka, BirgitRabella, NuriaRahamat-Langendoen, Janette CRainetova, PetraReynders, MarijkeRiezebos-Brilman, AnneliesRoorda, LieuweSavolainen-Kopra, CaritaSchuffenecker, IsabelleSmeets, Leo CStoyanova, AsyaStefic, KarlSwanink, CarolineTabain, IrenaTjhie, JeroenThouault, LucTumiotto, CamilleUceda Renteria, SaraUršič, TinaVallet, SophieVan Ranst, MarcVan Wunnik, PeterVerweij, Jaco JVila, JorginaWintermans, BasWollants, ElkeWolthers, Katja CXavier López-Labrador, FFischer, Thea KølsenHarvala, HeliBenschop, Kimberley SMEuropean Non-Polio Enterovirus Network (ENPEN)Acute flaccid myelitis (AFM)Enterovirus D68 (EV-D68)Nonpolio enterovirus (NPEV)Respiratory infectionAdolescentAdultAgedCentral Nervous System Viral DiseasesChildChild, PreschoolEnterovirus D, HumanEnterovirus InfectionsEuropeFemaleHumansInfantInfant, NewbornMaleMiddle AgedMyelitisNeuromuscular DiseasesPhylogenyRespiratory Tract InfectionsYoung AdultEnterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of EV-D68 infections and its clinical impact during the fall-winter season of 2021-2022. From 19 European countries, 58 institutes reported 10 481 (6.8%) EV-positive samples of which 1004 (9.6%) were identified as EV-D68 (including 852 respiratory samples). Clinical data were reported for 969 cases; 78.9% of infections were reported in children (0-5 years); and 37.9% of cases were hospitalized. Acute respiratory distress was commonly noted (93.1%) followed by fever (49.4%). Neurological problems were observed in 6.4% of cases including 6 diagnosed with AFM. Phylodynamic/Nextstrain and phylogenetic analyses based on 694 sequences showed the emergence of 2 novel B3-derived lineages, with no regional clustering. In conclusion, we describe a large-scale European EV-D68 upsurge with severe clinical impact and the emergence of B3-derived lineages.Oxford University PressAustrian Federal Ministry of Health (Austria)Ministry of Health (República Checa)Instituto de Salud Carlos IIICentro de Investigación Biomédica en Red - CIBERESP (Epidemiología y Salud Pública)Santé Publique FranceUnión Europea. Comisión Europea. NextGenerationEUMinistry of Health Welfare and Sport (Países Bajos)National Institutes of Health (Estados Unidos)Slovenian Research AgencySwiss National Science Foundation20252025-03-1220242024-10-1620242024-10-16research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://hdl.handle.net/20.500.12105/26435reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)InglésengES PI18CIII-00035 Not availableEC PE00000007 Not availableopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/264352026-06-12T12:43:37Z
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