Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021-2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study

Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of EV-D68 infections and its clinical impact during the fall-wi...

Descripción completa

Detalles Bibliográficos
Autores: Pires Simoes, Margarida, Hodcroft, Emma B, Simmonds, Peter, Albert, Jan, Alidjinou, Enagnon K, Ambert-Balay, Katia, Andrés, Cristina, Antón, Andrés, Auvray, Christelle, Bailly, Jean-Luc, Baldanti, Fausto, Bastings, Capser, Beard, Stuart, Berengua, Carla, Berginc, Natasa, Bloemen, Mandy, Blomqvist, Soile, Bosma, Froukje, Böttcher, Sindy, Bubba, Laura, Buderus, Stafan, Cabrerizo, Maria, Calvo, Cristina, Celma, Cristina, Ceriotti, Ferruccio, Clark, Gemma, Costa, Inës, Coste-Burel, Marianne, Couderé, Karen, Cremer, Jeroen, Del Cuerpo Casas, Margarita, Daehne, Theo, de Beer, Jessica, de Ceano-Vivas, Maria, De Gascun, Cillian, de Rougemont, Alexis, Dean, Jonathan, Dembinski, Jennifer L, Diedrich, Sabine, Diez-Domingo, Javier, Dillner, Lena, Dorenberg, Dagny H, Ducancelle, Alexandra, Dudman, Susanne, Dyrdak, Robert, Eis-Huebinger, Anna-Maria, Falces-Romero, Iker, Farkas, Agnes, Feeney, Susan, Fernandez-Garcia, Maria Dolores, Flipse, Jacky, Franck, Kristina T, Galli, Cristina, Garrigue, Isabelle, Geeraedts, Felix, Georgieva, Irina, Giardina, Federica, Guiomar, Raquel, Hauzenberger, Elenor, Heikens, Esther, Henquell, Cécille, Hober, Didier, Hönemann, Mario, Howson-Wells, Hannah, Hruškar, Željka, Ikonen, Niina, Imbert, Berthemarie, Jansz, Arjan R, Jeannoël, Marion, Jiřincová, Helena, Josset, Laurence, Keeren, Kathrin, Kramer-Lindhout, Naomie, Krokstad, Sidsel, Lazrek, Mouna, Le Guillou-Guillemette, Hélène, Lefeuvre, Caroline, Lind, Andreas, Lunar, Maja M, Maier, Melanie, Marque-Juillet, Stéphanie, McClure, C Patrick, McKenna, James, Meijer, Adam, Menasalvas Ruiz, Ana, Mengual-Chuliá, Beatriz, Midgley, Sofie, Mirand, Audrey, Molenkamp, Richard, Montes, Milagrosa, Moreno-Docón, Antonio, Morley, Ursula, Murk, Jean-Luc, Navascués-Ortega, Ana, Nijhuis, Roel, Nikolaeva-Glomb, Lubomira, Nordbø, Svein A, Numanovic, Sanela, Oggioni, Massimo, Oñate Vergara, Eider, Pacaud, Jordi, Pacreau, Marie L, Panning, Marcus, Pariani, Elena, Pekova, Lili, Pellegrinelli, Laura, Petrovec, Miroslav, Pietsch, Corinna, Pilorge, Léa, Piñeiro, Luis, Piralla, Antonio, Poljak, Mario, Prochazka, Birgit, Rabella, Nuria, Rahamat-Langendoen, Janette C, Rainetova, Petra, Reynders, Marijke, Riezebos-Brilman, Annelies, Roorda, Lieuwe, Savolainen-Kopra, Carita, Schuffenecker, Isabelle, Smeets, Leo C, Stoyanova, Asya, Stefic, Karl, Swanink, Caroline, Tabain, Irena, Tjhie, Jeroen, Thouault, Luc, Tumiotto, Camille, Uceda Renteria, Sara, Uršič, Tina, Vallet, Sophie, Van Ranst, Marc, Van Wunnik, Peter, Verweij, Jaco J, Vila, Jorgina, Wintermans, Bas, Wollants, Elke, Wolthers, Katja C, Xavier López-Labrador, F, Fischer, Thea Kølsen, Harvala, Heli, Benschop, Kimberley SM
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/26435
Acceso en línea:https://hdl.handle.net/20.500.12105/26435
Access Level:acceso abierto
Palabra clave:European Non-Polio Enterovirus Network (ENPEN)
Acute flaccid myelitis (AFM)
Enterovirus D68 (EV-D68)
Nonpolio enterovirus (NPEV)
Respiratory infection
Adolescent
Adult
Aged
Central Nervous System Viral Diseases
Child
Child, Preschool
Enterovirus D, Human
Enterovirus Infections
Europe
Female
Humans
Infant
Infant, Newborn
Male
Middle Aged
Myelitis
Neuromuscular Diseases
Phylogeny
Respiratory Tract Infections
Young Adult
Descripción
Sumario:Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of EV-D68 infections and its clinical impact during the fall-winter season of 2021-2022. From 19 European countries, 58 institutes reported 10 481 (6.8%) EV-positive samples of which 1004 (9.6%) were identified as EV-D68 (including 852 respiratory samples). Clinical data were reported for 969 cases; 78.9% of infections were reported in children (0-5 years); and 37.9% of cases were hospitalized. Acute respiratory distress was commonly noted (93.1%) followed by fever (49.4%). Neurological problems were observed in 6.4% of cases including 6 diagnosed with AFM. Phylodynamic/Nextstrain and phylogenetic analyses based on 694 sequences showed the emergence of 2 novel B3-derived lineages, with no regional clustering. In conclusion, we describe a large-scale European EV-D68 upsurge with severe clinical impact and the emergence of B3-derived lineages.

Similares en LA Referencia