Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial

Cantero-González, I. (Irene)|||/items/b04dcd89-9899-4eee-9a2e-1605782528ed; Abete, I. (Itziar)|||/items/2a1e4080-f97c-44d3-9098-309677a889fb; Babio, N. (Nancy)|||/items/5b6a2a17-b695-4712-9e4d-e9f3371dcc3c; Aros, F. (Fernando)|||/items/399e060f-9616-4d06-a6fd-9a2b2badc2ce; Corella, D. (Dolores)|||/items/edf5ac4d-018f-446d-aa6e-2448c41a1e41; Estruch, R. (Ramón)|||/items/3e95ff5c-8b32-474d-a8d4-7b1425d89265; Fito, M. (Montserrat)|||/items/7de631e9-926b-4b1a-9964-0c0ca699df6b; Hebert, J.R. (James R.)|||/items/17b5bdcb-8e09-4860-a2f9-086cbc15a619; Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7; Pinto, X. (Xavier)|||/items/4c705373-b9ef-443a-be57-4ae3aea0fe1b; Portillo, M.P. (María P.)|||/items/a9b050ad-eb19-4d20-8574-d4b2da33c873; Ruiz-Canela, M. (Miguel)|||/items/e333fb32-07a9-4253-a095-1cea0db0f7e9; Shivappa, N. (Nitin)|||/items/bf543366-9205-4d81-a346-f799af38db17; Wärnberg, J. (Julia)|||/items/7ec96886-31ab-4a1d-8eb6-8cac5dabcc68; Gomez-Gracia, E. (Enrique)|||/items/89359409-0217-44dd-94b0-14f45dba2c99; Tur, J.A. (Josep A.)|||/items/de6900c2-c677-4762-9a97-8e585d1c019e; Salas-Salvado, J. (Jordi)|||/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6; Zulet, M.A. (María Ángeles)|||/items/0a10c4f7-ed81-4b2e-bffe-fbcb7fccd239; Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131

Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial

Background & aims: To assess the possible association between a validated Dietary Inflammatory Index (DII) and specific dietary components with suitable non-invasive markers of liver status in overweight and obese subjects within the PREDIMED study. Methods: A cross-sectional study encompassing...

Descripción completa

Detalles Bibliográficos
Autores:	Cantero-González, I. (Irene)\|\|\|/items/b04dcd89-9899-4eee-9a2e-1605782528ed, Abete, I. (Itziar)\|\|\|/items/2a1e4080-f97c-44d3-9098-309677a889fb, Babio, N. (Nancy)\|\|\|/items/5b6a2a17-b695-4712-9e4d-e9f3371dcc3c, Aros, F. (Fernando)\|\|\|/items/399e060f-9616-4d06-a6fd-9a2b2badc2ce, Corella, D. (Dolores)\|\|\|/items/edf5ac4d-018f-446d-aa6e-2448c41a1e41, Estruch, R. (Ramón)\|\|\|/items/3e95ff5c-8b32-474d-a8d4-7b1425d89265, Fito, M. (Montserrat)\|\|\|/items/7de631e9-926b-4b1a-9964-0c0ca699df6b, Hebert, J.R. (James R.)\|\|\|/items/17b5bdcb-8e09-4860-a2f9-086cbc15a619, Martínez-González, M.A. (Miguel Ángel)\|\|\|/items/8b591471-4165-4697-8534-cfa0ad5eb1b7, Pinto, X. (Xavier)\|\|\|/items/4c705373-b9ef-443a-be57-4ae3aea0fe1b, Portillo, M.P. (María P.)\|\|\|/items/a9b050ad-eb19-4d20-8574-d4b2da33c873, Ruiz-Canela, M. (Miguel)\|\|\|/items/e333fb32-07a9-4253-a095-1cea0db0f7e9, Shivappa, N. (Nitin)\|\|\|/items/bf543366-9205-4d81-a346-f799af38db17, Wärnberg, J. (Julia)\|\|\|/items/7ec96886-31ab-4a1d-8eb6-8cac5dabcc68, Gomez-Gracia, E. (Enrique)\|\|\|/items/89359409-0217-44dd-94b0-14f45dba2c99, Tur, J.A. (Josep A.)\|\|\|/items/de6900c2-c677-4762-9a97-8e585d1c019e, Salas-Salvado, J. (Jordi)\|\|\|/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6, Zulet, M.A. (María Ángeles)\|\|\|/items/0a10c4f7-ed81-4b2e-bffe-fbcb7fccd239, Martinez, J.A. (José Alfredo)\|\|\|/items/6a3581ea-897b-4439-a95c-19301775e131
Tipo de recurso:	artículo
Fecha de publicación:	2018
País:	España
Institución:	Universidad de Navarra
Repositorio:	Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:	español
OAI Identifier:	oai:dadun.unav.edu:10171/68265
Acceso en línea:	https://hdl.handle.net/10171/68265
Access Level:	acceso abierto
Palabra clave:	Liver Diet Inflammation NAFLD Obesity

id	ES_0e18f343de9a9727d9c87895b3573bae
oai_identifier_str	oai:dadun.unav.edu:10171/68265
network_acronym_str	ES
network_name_str	España
repository_id_str
spelling	Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trialCantero-González, I. (Irene)\|\|\|/items/b04dcd89-9899-4eee-9a2e-1605782528edAbete, I. (Itziar)\|\|\|/items/2a1e4080-f97c-44d3-9098-309677a889fbBabio, N. (Nancy)\|\|\|/items/5b6a2a17-b695-4712-9e4d-e9f3371dcc3cAros, F. (Fernando)\|\|\|/items/399e060f-9616-4d06-a6fd-9a2b2badc2ceCorella, D. (Dolores)\|\|\|/items/edf5ac4d-018f-446d-aa6e-2448c41a1e41Estruch, R. (Ramón)\|\|\|/items/3e95ff5c-8b32-474d-a8d4-7b1425d89265Fito, M. (Montserrat)\|\|\|/items/7de631e9-926b-4b1a-9964-0c0ca699df6bHebert, J.R. (James R.)\|\|\|/items/17b5bdcb-8e09-4860-a2f9-086cbc15a619Martínez-González, M.A. (Miguel Ángel)\|\|\|/items/8b591471-4165-4697-8534-cfa0ad5eb1b7Pinto, X. (Xavier)\|\|\|/items/4c705373-b9ef-443a-be57-4ae3aea0fe1bPortillo, M.P. (María P.)\|\|\|/items/a9b050ad-eb19-4d20-8574-d4b2da33c873Ruiz-Canela, M. (Miguel)\|\|\|/items/e333fb32-07a9-4253-a095-1cea0db0f7e9Shivappa, N. (Nitin)\|\|\|/items/bf543366-9205-4d81-a346-f799af38db17Wärnberg, J. (Julia)\|\|\|/items/7ec96886-31ab-4a1d-8eb6-8cac5dabcc68Gomez-Gracia, E. (Enrique)\|\|\|/items/89359409-0217-44dd-94b0-14f45dba2c99Tur, J.A. (Josep A.)\|\|\|/items/de6900c2-c677-4762-9a97-8e585d1c019eSalas-Salvado, J. (Jordi)\|\|\|/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6Zulet, M.A. (María Ángeles)\|\|\|/items/0a10c4f7-ed81-4b2e-bffe-fbcb7fccd239Martinez, J.A. (José Alfredo)\|\|\|/items/6a3581ea-897b-4439-a95c-19301775e131LiverDietInflammationNAFLDObesityBackground & aims: To assess the possible association between a validated Dietary Inflammatory Index (DII) and specific dietary components with suitable non-invasive markers of liver status in overweight and obese subjects within the PREDIMED study. Methods: A cross-sectional study encompassing 794 randomized overweight and obese participants (mean ± SD age: 67.0 ± 5.0 y, 55% females) from the PREDIMED (PREvencion con DIeta MEDiterr anea) trial was conducted. DII is a validated tool evaluating the effect of diet on six inflammatory biomarkers (IL-1b, IL-4, IL-6, IL-10, TNF-a and C-reactive protein). Furthermore, a validated 137-item food-frequencyquestionnaire was used to obtain the information about the food intake. In addition, anthropometric measurements and several non-invasive markers of liver status were assessed and the Fatty Liver Index (FLI) score was calculated. Results: A higher DII and lower adherence to Mediterranean diet (MeDiet) were associated with a higher degree of liver damage (FLI > 60) in obese as compared to overweight participants. Furthermore, the DII score was positively associated with relevant non-invasive liver markers (ALT, AST, GGT and FLI) and directly affected FLI values. Interestingly, a positive correlation was observed between liver damage (>50th percentile FLI) and nutrients and foods linked to a pro-inflammatory dietary pattern. Conclusions: This study reinforced the concept that obesity is associated with liver damage and revealed that the consumption of a pro-inflammatory dietary pattern might contribute to obesity and fatty liver disease features. These data suggest that a well-designed precision diet including putative antiinflammatory components could specifically prevent and ameliorate non-alcoholic fatty liver manifestations in addition to obesity.Dadun. Depósito Académico Digital Universidad de Navarra20242024-01-1020182018-01-0120182018-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/68265reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraEspañolspaopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/682652026-06-21T12:47:57Z
dc.title.none.fl_str_mv	Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial
title	Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial
spellingShingle	Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial Cantero-González, I. (Irene)\|\|\|/items/b04dcd89-9899-4eee-9a2e-1605782528ed Liver Diet Inflammation NAFLD Obesity
title_short	Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial
title_full	Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial
title_fullStr	Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial
title_full_unstemmed	Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial
title_sort	Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial
dc.creator.none.fl_str_mv	Cantero-González, I. (Irene)\|\|\|/items/b04dcd89-9899-4eee-9a2e-1605782528ed Abete, I. (Itziar)\|\|\|/items/2a1e4080-f97c-44d3-9098-309677a889fb Babio, N. (Nancy)\|\|\|/items/5b6a2a17-b695-4712-9e4d-e9f3371dcc3c Aros, F. (Fernando)\|\|\|/items/399e060f-9616-4d06-a6fd-9a2b2badc2ce Corella, D. (Dolores)\|\|\|/items/edf5ac4d-018f-446d-aa6e-2448c41a1e41 Estruch, R. (Ramón)\|\|\|/items/3e95ff5c-8b32-474d-a8d4-7b1425d89265 Fito, M. (Montserrat)\|\|\|/items/7de631e9-926b-4b1a-9964-0c0ca699df6b Hebert, J.R. (James R.)\|\|\|/items/17b5bdcb-8e09-4860-a2f9-086cbc15a619 Martínez-González, M.A. (Miguel Ángel)\|\|\|/items/8b591471-4165-4697-8534-cfa0ad5eb1b7 Pinto, X. (Xavier)\|\|\|/items/4c705373-b9ef-443a-be57-4ae3aea0fe1b Portillo, M.P. (María P.)\|\|\|/items/a9b050ad-eb19-4d20-8574-d4b2da33c873 Ruiz-Canela, M. (Miguel)\|\|\|/items/e333fb32-07a9-4253-a095-1cea0db0f7e9 Shivappa, N. (Nitin)\|\|\|/items/bf543366-9205-4d81-a346-f799af38db17 Wärnberg, J. (Julia)\|\|\|/items/7ec96886-31ab-4a1d-8eb6-8cac5dabcc68 Gomez-Gracia, E. (Enrique)\|\|\|/items/89359409-0217-44dd-94b0-14f45dba2c99 Tur, J.A. (Josep A.)\|\|\|/items/de6900c2-c677-4762-9a97-8e585d1c019e Salas-Salvado, J. (Jordi)\|\|\|/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6 Zulet, M.A. (María Ángeles)\|\|\|/items/0a10c4f7-ed81-4b2e-bffe-fbcb7fccd239 Martinez, J.A. (José Alfredo)\|\|\|/items/6a3581ea-897b-4439-a95c-19301775e131
author	Cantero-González, I. (Irene)\|\|\|/items/b04dcd89-9899-4eee-9a2e-1605782528ed
author_facet	Cantero-González, I. (Irene)\|\|\|/items/b04dcd89-9899-4eee-9a2e-1605782528ed Abete, I. (Itziar)\|\|\|/items/2a1e4080-f97c-44d3-9098-309677a889fb Babio, N. (Nancy)\|\|\|/items/5b6a2a17-b695-4712-9e4d-e9f3371dcc3c Aros, F. (Fernando)\|\|\|/items/399e060f-9616-4d06-a6fd-9a2b2badc2ce Corella, D. (Dolores)\|\|\|/items/edf5ac4d-018f-446d-aa6e-2448c41a1e41 Estruch, R. (Ramón)\|\|\|/items/3e95ff5c-8b32-474d-a8d4-7b1425d89265 Fito, M. (Montserrat)\|\|\|/items/7de631e9-926b-4b1a-9964-0c0ca699df6b Hebert, J.R. (James R.)\|\|\|/items/17b5bdcb-8e09-4860-a2f9-086cbc15a619 Martínez-González, M.A. (Miguel Ángel)\|\|\|/items/8b591471-4165-4697-8534-cfa0ad5eb1b7 Pinto, X. (Xavier)\|\|\|/items/4c705373-b9ef-443a-be57-4ae3aea0fe1b Portillo, M.P. (María P.)\|\|\|/items/a9b050ad-eb19-4d20-8574-d4b2da33c873 Ruiz-Canela, M. (Miguel)\|\|\|/items/e333fb32-07a9-4253-a095-1cea0db0f7e9 Shivappa, N. (Nitin)\|\|\|/items/bf543366-9205-4d81-a346-f799af38db17 Wärnberg, J. (Julia)\|\|\|/items/7ec96886-31ab-4a1d-8eb6-8cac5dabcc68 Gomez-Gracia, E. (Enrique)\|\|\|/items/89359409-0217-44dd-94b0-14f45dba2c99 Tur, J.A. (Josep A.)\|\|\|/items/de6900c2-c677-4762-9a97-8e585d1c019e Salas-Salvado, J. (Jordi)\|\|\|/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6 Zulet, M.A. (María Ángeles)\|\|\|/items/0a10c4f7-ed81-4b2e-bffe-fbcb7fccd239 Martinez, J.A. (José Alfredo)\|\|\|/items/6a3581ea-897b-4439-a95c-19301775e131
author_role	author
author2	Abete, I. (Itziar)\|\|\|/items/2a1e4080-f97c-44d3-9098-309677a889fb Babio, N. (Nancy)\|\|\|/items/5b6a2a17-b695-4712-9e4d-e9f3371dcc3c Aros, F. (Fernando)\|\|\|/items/399e060f-9616-4d06-a6fd-9a2b2badc2ce Corella, D. (Dolores)\|\|\|/items/edf5ac4d-018f-446d-aa6e-2448c41a1e41 Estruch, R. (Ramón)\|\|\|/items/3e95ff5c-8b32-474d-a8d4-7b1425d89265 Fito, M. (Montserrat)\|\|\|/items/7de631e9-926b-4b1a-9964-0c0ca699df6b Hebert, J.R. (James R.)\|\|\|/items/17b5bdcb-8e09-4860-a2f9-086cbc15a619 Martínez-González, M.A. (Miguel Ángel)\|\|\|/items/8b591471-4165-4697-8534-cfa0ad5eb1b7 Pinto, X. (Xavier)\|\|\|/items/4c705373-b9ef-443a-be57-4ae3aea0fe1b Portillo, M.P. (María P.)\|\|\|/items/a9b050ad-eb19-4d20-8574-d4b2da33c873 Ruiz-Canela, M. (Miguel)\|\|\|/items/e333fb32-07a9-4253-a095-1cea0db0f7e9 Shivappa, N. (Nitin)\|\|\|/items/bf543366-9205-4d81-a346-f799af38db17 Wärnberg, J. (Julia)\|\|\|/items/7ec96886-31ab-4a1d-8eb6-8cac5dabcc68 Gomez-Gracia, E. (Enrique)\|\|\|/items/89359409-0217-44dd-94b0-14f45dba2c99 Tur, J.A. (Josep A.)\|\|\|/items/de6900c2-c677-4762-9a97-8e585d1c019e Salas-Salvado, J. (Jordi)\|\|\|/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6 Zulet, M.A. (María Ángeles)\|\|\|/items/0a10c4f7-ed81-4b2e-bffe-fbcb7fccd239 Martinez, J.A. (José Alfredo)\|\|\|/items/6a3581ea-897b-4439-a95c-19301775e131
author2_role	author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv	Liver Diet Inflammation NAFLD Obesity
topic	Liver Diet Inflammation NAFLD Obesity
description	Background & aims: To assess the possible association between a validated Dietary Inflammatory Index (DII) and specific dietary components with suitable non-invasive markers of liver status in overweight and obese subjects within the PREDIMED study. Methods: A cross-sectional study encompassing 794 randomized overweight and obese participants (mean ± SD age: 67.0 ± 5.0 y, 55% females) from the PREDIMED (PREvencion con DIeta MEDiterr anea) trial was conducted. DII is a validated tool evaluating the effect of diet on six inflammatory biomarkers (IL-1b, IL-4, IL-6, IL-10, TNF-a and C-reactive protein). Furthermore, a validated 137-item food-frequencyquestionnaire was used to obtain the information about the food intake. In addition, anthropometric measurements and several non-invasive markers of liver status were assessed and the Fatty Liver Index (FLI) score was calculated. Results: A higher DII and lower adherence to Mediterranean diet (MeDiet) were associated with a higher degree of liver damage (FLI > 60) in obese as compared to overweight participants. Furthermore, the DII score was positively associated with relevant non-invasive liver markers (ALT, AST, GGT and FLI) and directly affected FLI values. Interestingly, a positive correlation was observed between liver damage (>50th percentile FLI) and nutrients and foods linked to a pro-inflammatory dietary pattern. Conclusions: This study reinforced the concept that obesity is associated with liver damage and revealed that the consumption of a pro-inflammatory dietary pattern might contribute to obesity and fatty liver disease features. These data suggest that a well-designed precision diet including putative antiinflammatory components could specifically prevent and ameliorate non-alcoholic fatty liver manifestations in addition to obesity.
publishDate	2018
dc.date.none.fl_str_mv	2018 2018-01-01 2018 2018-01-01 2024 2024-01-10
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10171/68265
url	https://hdl.handle.net/10171/68265
dc.language.none.fl_str_mv	Español spa
language_invalid_str_mv	Español
language	spa
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.source.none.fl_str_mv	reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra
instname_str	Universidad de Navarra
reponame_str	Dadun. Depósito Académico Digital de la Universidad de Navarra
collection	Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_	1869403376463118336
score	15,300724

Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial

Similares en LA Referencia