Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial

Background & aims: To assess the possible association between a validated Dietary Inflammatory Index (DII) and specific dietary components with suitable non-invasive markers of liver status in overweight and obese subjects within the PREDIMED study. Methods: A cross-sectional study encompassing...

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Autores: Cantero-González, I. (Irene)|||/items/b04dcd89-9899-4eee-9a2e-1605782528ed, Abete, I. (Itziar)|||/items/2a1e4080-f97c-44d3-9098-309677a889fb, Babio, N. (Nancy)|||/items/5b6a2a17-b695-4712-9e4d-e9f3371dcc3c, Aros, F. (Fernando)|||/items/399e060f-9616-4d06-a6fd-9a2b2badc2ce, Corella, D. (Dolores)|||/items/edf5ac4d-018f-446d-aa6e-2448c41a1e41, Estruch, R. (Ramón)|||/items/3e95ff5c-8b32-474d-a8d4-7b1425d89265, Fito, M. (Montserrat)|||/items/7de631e9-926b-4b1a-9964-0c0ca699df6b, Hebert, J.R. (James R.)|||/items/17b5bdcb-8e09-4860-a2f9-086cbc15a619, Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7, Pinto, X. (Xavier)|||/items/4c705373-b9ef-443a-be57-4ae3aea0fe1b, Portillo, M.P. (María P.)|||/items/a9b050ad-eb19-4d20-8574-d4b2da33c873, Ruiz-Canela, M. (Miguel)|||/items/e333fb32-07a9-4253-a095-1cea0db0f7e9, Shivappa, N. (Nitin)|||/items/bf543366-9205-4d81-a346-f799af38db17, Wärnberg, J. (Julia)|||/items/7ec96886-31ab-4a1d-8eb6-8cac5dabcc68, Gomez-Gracia, E. (Enrique)|||/items/89359409-0217-44dd-94b0-14f45dba2c99, Tur, J.A. (Josep A.)|||/items/de6900c2-c677-4762-9a97-8e585d1c019e, Salas-Salvado, J. (Jordi)|||/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6, Zulet, M.A. (María Ángeles)|||/items/0a10c4f7-ed81-4b2e-bffe-fbcb7fccd239, Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:español
OAI Identifier:oai:dadun.unav.edu:10171/68265
Acceso en línea:https://hdl.handle.net/10171/68265
Access Level:acceso abierto
Palabra clave:Liver
Diet
Inflammation
NAFLD
Obesity
Descripción
Sumario:Background & aims: To assess the possible association between a validated Dietary Inflammatory Index (DII) and specific dietary components with suitable non-invasive markers of liver status in overweight and obese subjects within the PREDIMED study. Methods: A cross-sectional study encompassing 794 randomized overweight and obese participants (mean ± SD age: 67.0 ± 5.0 y, 55% females) from the PREDIMED (PREvencion con DIeta MEDiterr anea) trial was conducted. DII is a validated tool evaluating the effect of diet on six inflammatory biomarkers (IL-1b, IL-4, IL-6, IL-10, TNF-a and C-reactive protein). Furthermore, a validated 137-item food-frequencyquestionnaire was used to obtain the information about the food intake. In addition, anthropometric measurements and several non-invasive markers of liver status were assessed and the Fatty Liver Index (FLI) score was calculated. Results: A higher DII and lower adherence to Mediterranean diet (MeDiet) were associated with a higher degree of liver damage (FLI > 60) in obese as compared to overweight participants. Furthermore, the DII score was positively associated with relevant non-invasive liver markers (ALT, AST, GGT and FLI) and directly affected FLI values. Interestingly, a positive correlation was observed between liver damage (>50th percentile FLI) and nutrients and foods linked to a pro-inflammatory dietary pattern. Conclusions: This study reinforced the concept that obesity is associated with liver damage and revealed that the consumption of a pro-inflammatory dietary pattern might contribute to obesity and fatty liver disease features. These data suggest that a well-designed precision diet including putative antiinflammatory components could specifically prevent and ameliorate non-alcoholic fatty liver manifestations in addition to obesity.

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