Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial
Background & aims: To assess the possible association between a validated Dietary Inflammatory Index (DII) and specific dietary components with suitable non-invasive markers of liver status in overweight and obese subjects within the PREDIMED study. Methods: A cross-sectional study encompassing...
| Autores: | , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Instituto de Salud Carlos III (ISCIII) |
| Repositorio: | Repisalud |
| Idioma: | inglés |
| OAI Identifier: | oai:repisalud.isciii.es:20.500.12105/22638 |
| Acceso en línea: | https://hdl.handle.net/20.500.12105/22638 |
| Access Level: | acceso abierto |
| Palabra clave: | Liver Diet Inflammation NAFLD Obesity Dieta Mediterránea Registros de Dieta Biomarcadores Femenino Enfermedad del Hígado Graso no Alcohólico Dieta Factor de Necrosis Tumoral alfa Proteína C-Reactiva Masculino Estudios Transversales Cooperación del Paciente Interleucinas Humanos Persona de Mediana Edad Obesidad Inflamación Anciano Encuestas y Cuestionarios Sobrepeso Adiposidad Aged Humans C-Reactive Protein Middle Aged Non-alcoholic Fatty Liver Disease Cross-Sectional Studies Interleukins Male Biomarkers Patient Compliance Tumor Necrosis Factor-alpha Female Adiposity Diet, Mediterranean Overweight Diet Records |
| Sumario: | Background & aims: To assess the possible association between a validated Dietary Inflammatory Index (DII) and specific dietary components with suitable non-invasive markers of liver status in overweight and obese subjects within the PREDIMED study. Methods: A cross-sectional study encompassing 794 randomized overweight and obese participants (mean +/- SD age: 67.0 +/- 5.0 y, 55% females) from the PREDIMED (PREvencion con Dleta MEDiterranea) trial was conducted. DII is a validated tool evaluating the effect of diet on six inflammatory biomarkers (IL-1b, IL-4, IL-6, IL-10, TNF-alpha and C-reactive protein). Furthermore, a validated 137-item food-frequency-questionnaire was used to obtain the information about the food intake. In addition, anthropometric measurements and several non-invasive markers of liver status were assessed and the Fatty Liver Index (FLI) score was calculated. Results: A higher DII and lower adherence to Mediterranean diet (MeDiet) were associated with a higher degree of liver damage (FLI > 60) in obese as compared to overweight participants. Furthermore, the DII score was positively associated with relevant non-invasive liver markers (ALT, AST, GGT and FLI) and directly affected FLI values. Interestingly, a positive correlation was observed between liver damage (>50th percentile FLI) and nutrients and foods linked to a pro-inflammatory dietary pattern. Conclusions: This study reinforced the concept that obesity is associated with liver damage and revealed that the consumption of a pro-inflammatory dietary pattern might contribute to obesity and fatty liver disease features. These data suggest that a well-designed precision diet including putative anti-inflammatory components could specifically prevent and ameliorate non-alcoholic fatty liver manifestations in addition to obesity. |
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