Genome-wide phenotypic RNAi screen in the Drosophila wing: Phenotypic description of functional classes

The Drosophila genome contains approximately 14,000 protein-coding genes encoding all the necessary information to sustain cellular physiology, tissue organization, organism development, and behavior. In this manuscript, we describe in some detail the phenotypes in the adult fly wing generated after...

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Autores: López-Varea, Ana, Vega Cuesta, Patricia, Ruiz Gómez, Ana, Ostalé, Cristina M., Molnar, Cristina, Hevia, Covadonga F., Martín, Mercedes, Organista, Maria F., De Celis, Jesús, Culí, Joaquín, Esteban, Nuria, De Celis, Jose F.
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/704566
Acceso en línea:http://hdl.handle.net/10486/704566
https://dx.doi.org/10.1093/g3journal/jkab349
Access Level:acceso abierto
Palabra clave:Drosophila
Drosophila Proteins
Phenotype
RNA Interference
Wings, Animal
Genetics
Metabolism
Biología y Biomedicina / Biología
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spelling Genome-wide phenotypic RNAi screen in the Drosophila wing: Phenotypic description of functional classesLópez-Varea, AnaVega Cuesta, PatriciaRuiz Gómez, AnaOstalé, Cristina M.Molnar, CristinaHevia, Covadonga F.Martín, MercedesOrganista, Maria F.De Celis, JesúsCulí, JoaquínEsteban, NuriaDe Celis, Jose F.DrosophilaDrosophila ProteinsPhenotypeRNA InterferenceWings, AnimalGeneticsMetabolismBiología y Biomedicina / BiologíaThe Drosophila genome contains approximately 14,000 protein-coding genes encoding all the necessary information to sustain cellular physiology, tissue organization, organism development, and behavior. In this manuscript, we describe in some detail the phenotypes in the adult fly wing generated after knockdown of approximately 80% of Drosophila genes. We combined this phenotypic description with a comprehensive molecular classification of the Drosophila proteins into classes that summarize the main expected or known biochemical/functional aspect of each protein. This information, combined with mRNA expression levels and in situ expression patterns, provides a simplified atlas of the Drosophila genome, from housekeeping proteins to the components of the signaling pathways directing wing development, that might help to further understand the contribution of each gene group to wing formationOxford University PressDepartamento de Biología MolecularFacultad de Ciencias20212021-12-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/704566https://dx.doi.org/10.1093/g3journal/jkab349reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7045662026-06-23T12:46:27Z
dc.title.none.fl_str_mv Genome-wide phenotypic RNAi screen in the Drosophila wing: Phenotypic description of functional classes
title Genome-wide phenotypic RNAi screen in the Drosophila wing: Phenotypic description of functional classes
spellingShingle Genome-wide phenotypic RNAi screen in the Drosophila wing: Phenotypic description of functional classes
López-Varea, Ana
Drosophila
Drosophila Proteins
Phenotype
RNA Interference
Wings, Animal
Genetics
Metabolism
Biología y Biomedicina / Biología
title_short Genome-wide phenotypic RNAi screen in the Drosophila wing: Phenotypic description of functional classes
title_full Genome-wide phenotypic RNAi screen in the Drosophila wing: Phenotypic description of functional classes
title_fullStr Genome-wide phenotypic RNAi screen in the Drosophila wing: Phenotypic description of functional classes
title_full_unstemmed Genome-wide phenotypic RNAi screen in the Drosophila wing: Phenotypic description of functional classes
title_sort Genome-wide phenotypic RNAi screen in the Drosophila wing: Phenotypic description of functional classes
dc.creator.none.fl_str_mv López-Varea, Ana
Vega Cuesta, Patricia
Ruiz Gómez, Ana
Ostalé, Cristina M.
Molnar, Cristina
Hevia, Covadonga F.
Martín, Mercedes
Organista, Maria F.
De Celis, Jesús
Culí, Joaquín
Esteban, Nuria
De Celis, Jose F.
author López-Varea, Ana
author_facet López-Varea, Ana
Vega Cuesta, Patricia
Ruiz Gómez, Ana
Ostalé, Cristina M.
Molnar, Cristina
Hevia, Covadonga F.
Martín, Mercedes
Organista, Maria F.
De Celis, Jesús
Culí, Joaquín
Esteban, Nuria
De Celis, Jose F.
author_role author
author2 Vega Cuesta, Patricia
Ruiz Gómez, Ana
Ostalé, Cristina M.
Molnar, Cristina
Hevia, Covadonga F.
Martín, Mercedes
Organista, Maria F.
De Celis, Jesús
Culí, Joaquín
Esteban, Nuria
De Celis, Jose F.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Biología Molecular
Facultad de Ciencias
dc.subject.none.fl_str_mv Drosophila
Drosophila Proteins
Phenotype
RNA Interference
Wings, Animal
Genetics
Metabolism
Biología y Biomedicina / Biología
topic Drosophila
Drosophila Proteins
Phenotype
RNA Interference
Wings, Animal
Genetics
Metabolism
Biología y Biomedicina / Biología
description The Drosophila genome contains approximately 14,000 protein-coding genes encoding all the necessary information to sustain cellular physiology, tissue organization, organism development, and behavior. In this manuscript, we describe in some detail the phenotypes in the adult fly wing generated after knockdown of approximately 80% of Drosophila genes. We combined this phenotypic description with a comprehensive molecular classification of the Drosophila proteins into classes that summarize the main expected or known biochemical/functional aspect of each protein. This information, combined with mRNA expression levels and in situ expression patterns, provides a simplified atlas of the Drosophila genome, from housekeeping proteins to the components of the signaling pathways directing wing development, that might help to further understand the contribution of each gene group to wing formation
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-12-01
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/704566
https://dx.doi.org/10.1093/g3journal/jkab349
url http://hdl.handle.net/10486/704566
https://dx.doi.org/10.1093/g3journal/jkab349
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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