Synthesis, characterization, and magnetic and antibacterial properties of a novel iron(III) complex (CH3)2NH2[Fe(phen)Cl4]

A novel iron(III) complex (CH3)2NH2[Fe(phen)Cl4] (1) (phen = 1,10-phenanthroline) was synthesized, its structure was fully characterized using different techniques, and its in vitro antibacterial activity against various antibiotic-resistant Gram-positive and Gram-negative bacteria was evaluated. Th...

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Autores: Abdelhadi, Asmae Ben, Rodríguez-Sánchez, Sara, Ouarsal, Rachid, Saadi, Mohamed, Ammari, Lahcen El, Morley, Nicola, Bali, Brahim El, Gómez-Torres, Óscar, Lachkar, Mohammed, Douhal, Abderrazzak
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad de Castilla-La Mancha
Repositorio:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:ruidera.uclm.es:10578/43260
Acceso en línea:https://hdl.handle.net/10578/43260
Access Level:acceso abierto
Palabra clave:magnetic and antibacterial properties
química física
iron(III) complex
(CH3)2NH2[Fe(phen)Cl4]
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spelling Synthesis, characterization, and magnetic and antibacterial properties of a novel iron(III) complex (CH3)2NH2[Fe(phen)Cl4]Abdelhadi, Asmae BenRodríguez-Sánchez, SaraOuarsal, RachidSaadi, MohamedAmmari, Lahcen ElMorley, NicolaBali, Brahim ElGómez-Torres, ÓscarLachkar, MohammedDouhal, Abderrazzakmagnetic and antibacterial propertiesquímica físicairon(III) complex(CH3)2NH2[Fe(phen)Cl4]A novel iron(III) complex (CH3)2NH2[Fe(phen)Cl4] (1) (phen = 1,10-phenanthroline) was synthesized, its structure was fully characterized using different techniques, and its in vitro antibacterial activity against various antibiotic-resistant Gram-positive and Gram-negative bacteria was evaluated. The structure of 1 is made up of mononuclear [Fe(phen)Cl4]− anions and dimethylammonium cations (CH3)2NH2+. Iron(III) is hexacoordinated to two nitrogen atoms of chelating phenanthroline and four chlorides forming a distorted octahedral environment around the metal atom. Complex 1 crystallizes in a triclinic system with the P[1 with combining macron] space group. 3D Hirshfeld surfaces and 2D fingerprint plots show that H⋯Cl interactions are the major contributors in maintaining the total surface. IR and UV-visible spectra indicated the coordination of 1,10-phenanthroline to iron (III) metal. Thermal stability experiments revealed that 1 is stable up to 428 K. Magnetic susceptibility measurements indicated a paramagnetic behavior at high temperatures. In vitro antibacterial activity was explored against two Gram-positive bacteria, Staphylococcus aureus CECT 86 and Listeria monocytogenes CECT 4031, and two Gram-negative bacteria, Escherichia coli CECT 99 and Klebsiella pneumoniae CECT 143T, using the disc diffusion method. Complex 1 clearly showed good activity against these bacteria and is a potential candidate for treating bacterial infections and promoting further development in their treatment.Royal Society of Chemistry202520252024info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10578/43260reponame:RUIdeRA. Repositorio Institucional de la UCLMinstname:Universidad de Castilla-La ManchaInglésPID2020-116519RB-I00SBPLY/19/180501/0002122022-GRIN-3432592020-1-ES01-KA107-0798682019-PREDUCLM-10801info:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivs 3.0 Spainhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/oai:ruidera.uclm.es:10578/432602026-05-27T07:36:41Z
dc.title.none.fl_str_mv Synthesis, characterization, and magnetic and antibacterial properties of a novel iron(III) complex (CH3)2NH2[Fe(phen)Cl4]
title Synthesis, characterization, and magnetic and antibacterial properties of a novel iron(III) complex (CH3)2NH2[Fe(phen)Cl4]
spellingShingle Synthesis, characterization, and magnetic and antibacterial properties of a novel iron(III) complex (CH3)2NH2[Fe(phen)Cl4]
Abdelhadi, Asmae Ben
magnetic and antibacterial properties
química física
iron(III) complex
(CH3)2NH2[Fe(phen)Cl4]
title_short Synthesis, characterization, and magnetic and antibacterial properties of a novel iron(III) complex (CH3)2NH2[Fe(phen)Cl4]
title_full Synthesis, characterization, and magnetic and antibacterial properties of a novel iron(III) complex (CH3)2NH2[Fe(phen)Cl4]
title_fullStr Synthesis, characterization, and magnetic and antibacterial properties of a novel iron(III) complex (CH3)2NH2[Fe(phen)Cl4]
title_full_unstemmed Synthesis, characterization, and magnetic and antibacterial properties of a novel iron(III) complex (CH3)2NH2[Fe(phen)Cl4]
title_sort Synthesis, characterization, and magnetic and antibacterial properties of a novel iron(III) complex (CH3)2NH2[Fe(phen)Cl4]
dc.creator.none.fl_str_mv Abdelhadi, Asmae Ben
Rodríguez-Sánchez, Sara
Ouarsal, Rachid
Saadi, Mohamed
Ammari, Lahcen El
Morley, Nicola
Bali, Brahim El
Gómez-Torres, Óscar
Lachkar, Mohammed
Douhal, Abderrazzak
author Abdelhadi, Asmae Ben
author_facet Abdelhadi, Asmae Ben
Rodríguez-Sánchez, Sara
Ouarsal, Rachid
Saadi, Mohamed
Ammari, Lahcen El
Morley, Nicola
Bali, Brahim El
Gómez-Torres, Óscar
Lachkar, Mohammed
Douhal, Abderrazzak
author_role author
author2 Rodríguez-Sánchez, Sara
Ouarsal, Rachid
Saadi, Mohamed
Ammari, Lahcen El
Morley, Nicola
Bali, Brahim El
Gómez-Torres, Óscar
Lachkar, Mohammed
Douhal, Abderrazzak
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv magnetic and antibacterial properties
química física
iron(III) complex
(CH3)2NH2[Fe(phen)Cl4]
topic magnetic and antibacterial properties
química física
iron(III) complex
(CH3)2NH2[Fe(phen)Cl4]
description A novel iron(III) complex (CH3)2NH2[Fe(phen)Cl4] (1) (phen = 1,10-phenanthroline) was synthesized, its structure was fully characterized using different techniques, and its in vitro antibacterial activity against various antibiotic-resistant Gram-positive and Gram-negative bacteria was evaluated. The structure of 1 is made up of mononuclear [Fe(phen)Cl4]− anions and dimethylammonium cations (CH3)2NH2+. Iron(III) is hexacoordinated to two nitrogen atoms of chelating phenanthroline and four chlorides forming a distorted octahedral environment around the metal atom. Complex 1 crystallizes in a triclinic system with the P[1 with combining macron] space group. 3D Hirshfeld surfaces and 2D fingerprint plots show that H⋯Cl interactions are the major contributors in maintaining the total surface. IR and UV-visible spectra indicated the coordination of 1,10-phenanthroline to iron (III) metal. Thermal stability experiments revealed that 1 is stable up to 428 K. Magnetic susceptibility measurements indicated a paramagnetic behavior at high temperatures. In vitro antibacterial activity was explored against two Gram-positive bacteria, Staphylococcus aureus CECT 86 and Listeria monocytogenes CECT 4031, and two Gram-negative bacteria, Escherichia coli CECT 99 and Klebsiella pneumoniae CECT 143T, using the disc diffusion method. Complex 1 clearly showed good activity against these bacteria and is a potential candidate for treating bacterial infections and promoting further development in their treatment.
publishDate 2024
dc.date.none.fl_str_mv 2024
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10578/43260
url https://hdl.handle.net/10578/43260
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv PID2020-116519RB-I00
SBPLY/19/180501/000212
2022-GRIN-343259
2020-1-ES01-KA107-079868
2019-PREDUCLM-10801
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:RUIdeRA. Repositorio Institucional de la UCLM
instname:Universidad de Castilla-La Mancha
instname_str Universidad de Castilla-La Mancha
reponame_str RUIdeRA. Repositorio Institucional de la UCLM
collection RUIdeRA. Repositorio Institucional de la UCLM
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869403317693579264
score 15,811543

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