Synthesis, characterization, and magnetic and antibacterial properties of a novel iron(III) complex (CH3)2NH2[Fe(phen)Cl4]
A novel iron(III) complex (CH3)2NH2[Fe(phen)Cl4] (1) (phen = 1,10-phenanthroline) was synthesized, its structure was fully characterized using different techniques, and its in vitro antibacterial activity against various antibiotic-resistant Gram-positive and Gram-negative bacteria was evaluated. Th...
| Autores: | , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Universidad de Castilla-La Mancha |
| Repositorio: | RUIdeRA. Repositorio Institucional de la UCLM |
| OAI Identifier: | oai:ruidera.uclm.es:10578/43260 |
| Acceso en línea: | https://hdl.handle.net/10578/43260 |
| Access Level: | acceso abierto |
| Palabra clave: | magnetic and antibacterial properties química física iron(III) complex (CH3)2NH2[Fe(phen)Cl4] |
| Sumario: | A novel iron(III) complex (CH3)2NH2[Fe(phen)Cl4] (1) (phen = 1,10-phenanthroline) was synthesized, its structure was fully characterized using different techniques, and its in vitro antibacterial activity against various antibiotic-resistant Gram-positive and Gram-negative bacteria was evaluated. The structure of 1 is made up of mononuclear [Fe(phen)Cl4]− anions and dimethylammonium cations (CH3)2NH2+. Iron(III) is hexacoordinated to two nitrogen atoms of chelating phenanthroline and four chlorides forming a distorted octahedral environment around the metal atom. Complex 1 crystallizes in a triclinic system with the P[1 with combining macron] space group. 3D Hirshfeld surfaces and 2D fingerprint plots show that H⋯Cl interactions are the major contributors in maintaining the total surface. IR and UV-visible spectra indicated the coordination of 1,10-phenanthroline to iron (III) metal. Thermal stability experiments revealed that 1 is stable up to 428 K. Magnetic susceptibility measurements indicated a paramagnetic behavior at high temperatures. In vitro antibacterial activity was explored against two Gram-positive bacteria, Staphylococcus aureus CECT 86 and Listeria monocytogenes CECT 4031, and two Gram-negative bacteria, Escherichia coli CECT 99 and Klebsiella pneumoniae CECT 143T, using the disc diffusion method. Complex 1 clearly showed good activity against these bacteria and is a potential candidate for treating bacterial infections and promoting further development in their treatment. |
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