Characterization and prognostic implication of 17 chromosome abnormalities in myelodysplastic syndrome

The prognosis of chromosome 17 (chr17) abnormalities in patients with primary myelodysplastic syndrome (MDS) remains unclear. The revised International Prognostic Scoring System (IPSS-R) includes these abnormalities within the intermediate cytogenetic risk group. This study assessed the impact on ov...

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Autores: Sanchez-Castro, J, Marco-Betes, V, Gomez-Arbones, X, Arenillas, L, Valcarcel, D, Vallespi, T, Costa, D, Nomdedeu, B, Jimenez, MJ, Granada, I, Grau, J, Ardanaz, MT, de la Serna, J, Carbonell, F, Cervera, J, Sierra, A, Luno, E, Cervero, CJ, Falantes, J, Calasanz, MJ, Gonzalez-Porras, JR, Bailen, A, Amigo, ML, Sanz, G, Sole, F
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p14803
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=14803
Access Level:acceso abierto
Palabra clave:Myelodysplastic syndromes
Chromosome 17
Prognosis
Cytogenetic
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spelling Characterization and prognostic implication of 17 chromosome abnormalities in myelodysplastic syndromeSanchez-Castro, JMarco-Betes, VGomez-Arbones, XArenillas, LValcarcel, DVallespi, TCosta, DNomdedeu, BJimenez, MJGranada, IGrau, JArdanaz, MTde la Serna, JCarbonell, FCervera, JSierra, ALuno, ECervero, CJFalantes, JCalasanz, MJGonzalez-Porras, JRBailen, AAmigo, MLSanz, GSole, FMyelodysplastic syndromesChromosome 17PrognosisCytogeneticThe prognosis of chromosome 17 (chr17) abnormalities in patients with primary myelodysplastic syndrome (MDS) remains unclear. The revised International Prognostic Scoring System (IPSS-R) includes these abnormalities within the intermediate cytogenetic risk group. This study assessed the impact on overall survival ( OS) and risk of acute myeloid leukemia transformation (AMLt) of chr17 abnormalities in 88 patients with primary MDS. We have compared this group with 1346 patients with primary MDS and abnormal karyotype without chr17 involved. The alterations of chr17 should be considered within group of poor prognosis. The different types of alterations of chromosome 17 behave different prognosis. The study confirms the intermediate prognostic impact of the i(17q), as stated in IPSS-R. The results of the study, however, provide valuable new information on the prognostic impact of alterations of chromosome 17 in complex karyotypes. (C) 2013 Elsevier Ltd. All rights reserved.PERGAMON-ELSEVIER SCIENCE LTD2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=14803LEUKEMIA RESEARCHISSN: 01452126ISSNe: 18735835reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p148032026-06-14T12:41:47Z
dc.title.none.fl_str_mv Characterization and prognostic implication of 17 chromosome abnormalities in myelodysplastic syndrome
title Characterization and prognostic implication of 17 chromosome abnormalities in myelodysplastic syndrome
spellingShingle Characterization and prognostic implication of 17 chromosome abnormalities in myelodysplastic syndrome
Sanchez-Castro, J
Myelodysplastic syndromes
Chromosome 17
Prognosis
Cytogenetic
title_short Characterization and prognostic implication of 17 chromosome abnormalities in myelodysplastic syndrome
title_full Characterization and prognostic implication of 17 chromosome abnormalities in myelodysplastic syndrome
title_fullStr Characterization and prognostic implication of 17 chromosome abnormalities in myelodysplastic syndrome
title_full_unstemmed Characterization and prognostic implication of 17 chromosome abnormalities in myelodysplastic syndrome
title_sort Characterization and prognostic implication of 17 chromosome abnormalities in myelodysplastic syndrome
dc.creator.none.fl_str_mv Sanchez-Castro, J
Marco-Betes, V
Gomez-Arbones, X
Arenillas, L
Valcarcel, D
Vallespi, T
Costa, D
Nomdedeu, B
Jimenez, MJ
Granada, I
Grau, J
Ardanaz, MT
de la Serna, J
Carbonell, F
Cervera, J
Sierra, A
Luno, E
Cervero, CJ
Falantes, J
Calasanz, MJ
Gonzalez-Porras, JR
Bailen, A
Amigo, ML
Sanz, G
Sole, F
author Sanchez-Castro, J
author_facet Sanchez-Castro, J
Marco-Betes, V
Gomez-Arbones, X
Arenillas, L
Valcarcel, D
Vallespi, T
Costa, D
Nomdedeu, B
Jimenez, MJ
Granada, I
Grau, J
Ardanaz, MT
de la Serna, J
Carbonell, F
Cervera, J
Sierra, A
Luno, E
Cervero, CJ
Falantes, J
Calasanz, MJ
Gonzalez-Porras, JR
Bailen, A
Amigo, ML
Sanz, G
Sole, F
author_role author
author2 Marco-Betes, V
Gomez-Arbones, X
Arenillas, L
Valcarcel, D
Vallespi, T
Costa, D
Nomdedeu, B
Jimenez, MJ
Granada, I
Grau, J
Ardanaz, MT
de la Serna, J
Carbonell, F
Cervera, J
Sierra, A
Luno, E
Cervero, CJ
Falantes, J
Calasanz, MJ
Gonzalez-Porras, JR
Bailen, A
Amigo, ML
Sanz, G
Sole, F
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Myelodysplastic syndromes
Chromosome 17
Prognosis
Cytogenetic
topic Myelodysplastic syndromes
Chromosome 17
Prognosis
Cytogenetic
description The prognosis of chromosome 17 (chr17) abnormalities in patients with primary myelodysplastic syndrome (MDS) remains unclear. The revised International Prognostic Scoring System (IPSS-R) includes these abnormalities within the intermediate cytogenetic risk group. This study assessed the impact on overall survival ( OS) and risk of acute myeloid leukemia transformation (AMLt) of chr17 abnormalities in 88 patients with primary MDS. We have compared this group with 1346 patients with primary MDS and abnormal karyotype without chr17 involved. The alterations of chr17 should be considered within group of poor prognosis. The different types of alterations of chromosome 17 behave different prognosis. The study confirms the intermediate prognostic impact of the i(17q), as stated in IPSS-R. The results of the study, however, provide valuable new information on the prognostic impact of alterations of chromosome 17 in complex karyotypes. (C) 2013 Elsevier Ltd. All rights reserved.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=14803
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=14803
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv PERGAMON-ELSEVIER SCIENCE LTD
publisher.none.fl_str_mv PERGAMON-ELSEVIER SCIENCE LTD
dc.source.none.fl_str_mv LEUKEMIA RESEARCH
ISSN: 01452126
ISSNe: 18735835
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.198674

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