Characterization and prognostic implication of 17 chromosome abnormalities in myelodysplastic syndrome

The prognosis of chromosome 17 (chr17) abnormalities in patients with primary myelodysplastic syndrome (MDS) remains unclear. The revised International Prognostic Scoring System (IPSS-R) includes these abnormalities within the intermediate cytogenetic risk group. This study assessed the impact on ov...

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Detalles Bibliográficos
Autores: Sanchez-Castro, J, Marco-Betes, V, Gomez-Arbones, X, Arenillas, L, Valcarcel, D, Vallespi, T, Costa, D, Nomdedeu, B, Jimenez, MJ, Granada, I, Grau, J, Ardanaz, MT, de la Serna, J, Carbonell, F, Cervera, J, Sierra, A, Luno, E, Cervero, CJ, Falantes, J, Calasanz, MJ, Gonzalez-Porras, JR, Bailen, A, Amigo, ML, Sanz, G, Sole, F
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p14803
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=14803
Access Level:acceso abierto
Palabra clave:Myelodysplastic syndromes
Chromosome 17
Prognosis
Cytogenetic
Descripción
Sumario:The prognosis of chromosome 17 (chr17) abnormalities in patients with primary myelodysplastic syndrome (MDS) remains unclear. The revised International Prognostic Scoring System (IPSS-R) includes these abnormalities within the intermediate cytogenetic risk group. This study assessed the impact on overall survival ( OS) and risk of acute myeloid leukemia transformation (AMLt) of chr17 abnormalities in 88 patients with primary MDS. We have compared this group with 1346 patients with primary MDS and abnormal karyotype without chr17 involved. The alterations of chr17 should be considered within group of poor prognosis. The different types of alterations of chromosome 17 behave different prognosis. The study confirms the intermediate prognostic impact of the i(17q), as stated in IPSS-R. The results of the study, however, provide valuable new information on the prognostic impact of alterations of chromosome 17 in complex karyotypes. (C) 2013 Elsevier Ltd. All rights reserved.

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