Characterization and prognostic implication of 17 chromosome abnormalities in myelodysplastic syndrome

The prognosis of chromosome 17 (chr17) abnormalities in patients with primary myelodysplastic syndrome (MDS) remains unclear. The revised International Prognostic Scoring System (IPSS-R) includes these abnormalities within the intermediate cytogenetic risk group.This study assessed the impact on ove...

ver descrição completa

Detalhes bibliográficos
Autores: Sánchez Castro, Judit, Marco Betés, Victor, Gómez Arbonés, Javier, Arenillas, Leonor, Valcarcel, David, Vallespí, Teresa, Costa, Dolors, Nomdedeu, Benet, Jimenez, María José, Granada, Isabel, Grau, Javier, Ardanaz, María T., Serna, Javier de la, Carbonell, Félix, Cervera, José, Sierra, Adriana, Luño, Elisa, Cervero, Carlos J., Falantes, José, Calasanz, María J., González-Porrás, José R., Bailén, Alicia, Amigo, M. Luz, Sanz, Guillermo, Solé, Francesc
Formato: artículo
Estado:Versión enviada para evaluación y publicación
Fecha de publicación:2013
País:España
Recursos:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/48611
Acesso em linha:https://doi.org/10.1016/j.leukres.2013.04.010
http://hdl.handle.net/10459.1/48611
Access Level:acceso abierto
Palavra-chave:Myelodysplastic syndromes
Chromosome 17
prognosis
cytogenetic
Descrição
Resumo:The prognosis of chromosome 17 (chr17) abnormalities in patients with primary myelodysplastic syndrome (MDS) remains unclear. The revised International Prognostic Scoring System (IPSS-R) includes these abnormalities within the intermediate cytogenetic risk group.This study assessed the impact on overall survival (OS) and risk of acute myeloid leukemia transformation (AMLt) of chr17 abnormalities in 88 patients with primary MDS. We have compared this group with 1346 patients with primary MDS and abnormal karyotype without chr17 involved. The alterations of chr17 should be considered within group of poor prognosis. The different types of alterations of chromosome 17 behave different prognosis. The study confirms the intermediate prognostic impact of the i(17q), as stated in IPSS-R. The results of the study, however, provide valuable new information on the prognostic impact of alterations of chromosome 17 in complex karyotypes.

Registos relacionados