Clinical use and reporting of neurofilament quantification in neurological disorders

INTRODUCTION: Neurofilament light chain (NfL) quantification aids in diagnosing and predicting neurological disorders, but clinical and laboratory practices vary across centers. Differences in result interpretation and reporting further challenge test commutability. This study aimed to review the gl...

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Autores: Delaby, Constance|||0000-0002-8606-6814, Ladang, A., Martinez-Yriarte, J., Zecca, C., Logroscino, Giancarlo|||0000-0003-0423-3242, Körtvelyessy, P., Tumani, H., Parchi, P., Quadrio, I., Hart, M., Olsen, D.A., Alcolea, Daniel|||0000-0002-3819-3245, Blennow, Kaj|||0000-0002-1890-4193, Fortea, Juan|||0000-0002-1340-638X, Lleó, Alberto|||0000-0002-2568-5478, Algeciras-Schimnich, A., Ayrignac, X., Bedel, A., Santos, G.A.A., Borelli, W., Bouaziz-Amar, E., Baldeiras, I., Bigot-Corbel, E., Bjerke, M., Carretero Perez, M., Casoli, T., Chabrashvili, T., Chapman, Miles D., Cusato, J., Dursun, E., Fourier, A., Galimberti, Daniela|||0000-0002-9284-5953, Gezen-Ak, D., Gordon, B.A., Gouju, J., de las Heras Florez, S., Hernandez Sanchez, J., Herwerth, M., Imperiale, D., Kaczorowski, F., Kasuga, K., Keshavan, A., Khalil, Michael|||0000-0002-5350-3328, Kuhle, Jens|||0000-0002-6963-8892, Leithner, C., Lewczuk, P., Letournel, F., Tsolaki, Magda|||0000-0002-2072-8010, Giuffrè, G.M., Blanc, M.C., Mroczko, B., Martínez Rodríguez, José Enrique, Musso, G., Kulczynska-Przybik, A., Nogueira, L., Paquet, C., Baiardi, S., Gaetani, L., Parnetti, Lucilla|||0000-0001-5722-3967, Perez Garay, R., Poesen, K., Quillard-Muraine, M., Rodriguez-Borja, Enrique|||0000-0002-0339-6704, Schraen, S., Terracciano, D., Bachhuber, F., Halbgebauer, S., Tzartos, S., Tzartos, J., Unterwalder, N., Vermunt, L., Wellington, C.L., Zetterberg, Henrik|||0000-0003-3930-4354, Teunissen, Charlotte E.|||0000-0002-4061-0837, Lehmann, Sylvain|||0000-0001-6117-562X
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:322772
Acceso en línea:https://ddd.uab.cat/record/322772
https://dx.doi.org/urn:doi:10.1002/alz.70343
Access Level:acceso abierto
Palabra clave:Biomarkers
Blood
Cerebrospinal fluid
Clinical report
Consensus approach
Harmonization
Neurofilaments
Descripción
Sumario:INTRODUCTION: Neurofilament light chain (NfL) quantification aids in diagnosing and predicting neurological disorders, but clinical and laboratory practices vary across centers. Differences in result interpretation and reporting further challenge test commutability. This study aimed to review the global analytical and post-analytical methods used for NfL measurement in routine clinical practice across different contexts. METHODS: We established an international working group (WG) and distributed a survey to its members to gather information on context of use (COU), (pre) analytical methods, cutoff usage, as well as the interpretation and reporting of NfL measurements. RESULTS: Among the centers, 63% measured NfL in cerebrospinal fluid (CSF), 87% in blood, and 53% in both. COU was widespread, with 50% defining pathological cutoffs based on publications and 42% considering age. Reporting was primarily done through numeric results (95%). DISCUSSION: Harmonizing cutoffs, reporting, and interpretation across various clinical contexts will facilitate the incorporation of this biomarker into routine clinical practice. Highlights: Unique international overview of current analytical and post-analytical methods for neurofilament light chain (NfL) measurement in routine clinical practice. Tailored sheets for each neurological application. Strategies to harmonize cutoffs, reporting, and interpretation of NfL's measurement.

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