Bioavailability assessment of yarrow phenolic compounds using an in vitro digestion/Caco-2 cell model: Anti-inflammatory activity of basolateral fraction

This article belongs to the Special Issue Natural Polyphenols in Human Health.

Detalhes bibliográficos
Autores: Villalva, Marisol, Jaime, Laura, Siles-Sánchez, María de las Nieves, Santoyo, Susana
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/297178
Acesso em linha:http://hdl.handle.net/10261/297178
Access Level:acceso abierto
Palavra-chave:Achillea millefolium
Bioaccessibility
Caco-2 absorption
In vitro digestion
Phenolic compounds
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spelling Bioavailability assessment of yarrow phenolic compounds using an in vitro digestion/Caco-2 cell model: Anti-inflammatory activity of basolateral fractionVillalva, MarisolJaime, LauraSiles-Sánchez, María de las NievesSantoyo, SusanaAchillea millefoliumBioaccessibilityCaco-2 absorptionIn vitro digestionPhenolic compoundsThis article belongs to the Special Issue Natural Polyphenols in Human Health.In this study, a combined in vitro digestion/Caco-2 model was performed with the aim to determine the phenolic compounds bioavailability of two yarrow extracts. HPLC-PAD characterisation indicated that the main components in both extracts were 3,5-dicaffeoylquinic acid (DCQA) and luteolin-7-O-glucoside. Analyses after the simulated digestion process revealed that phenolic composition was not affected during the oral phase, whereas gastric and intestinal phases represented critical steps for some individual phenolics, especially intestinal step. The transition from gastric medium to intestinal environment caused an important degradation of 3,5-DCQA (63–67% loss), whereas 3,4-DCQA and 4,5-DCQA increased significantly, suggesting an isomeric transformation within these caffeic acid derivatives. However, an approx. 90% of luteolin-7-O-glucoside was recovered after intestinal step. At the end of Caco-2 absorption experiments, casticin, diosmetin and centaureidin represented the most abundant compounds in the basolateral fraction. Moreover, this fraction presented anti-inflammatory activity since was able to inhibit the secretion of IL-1β and IL-6 pro-inflammatory cytokines. Thus, the presence in the basolateral fraction of flavonoid-aglycones from yarrow, could be related with the observed anti-inflammatory activity from yarrow extract.This research was carried out by Spanish Government (Project: PID2019-110183RB-C22/AEI//10.13039/501100011033) and Comunidad Autónoma de Madrid (ALIBIRD2020-CM, project: S2018/BAA-4343).Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Comunidad de MadridConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/297178reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-110183RB-C22S2018/BAA-4343/ALIBIRD2020-CMMoleculesThe underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.3390/molecules27238254https://doi.org/10.3390/molecules27238254Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2971782026-05-22T06:33:51Z
dc.title.none.fl_str_mv Bioavailability assessment of yarrow phenolic compounds using an in vitro digestion/Caco-2 cell model: Anti-inflammatory activity of basolateral fraction
title Bioavailability assessment of yarrow phenolic compounds using an in vitro digestion/Caco-2 cell model: Anti-inflammatory activity of basolateral fraction
spellingShingle Bioavailability assessment of yarrow phenolic compounds using an in vitro digestion/Caco-2 cell model: Anti-inflammatory activity of basolateral fraction
Villalva, Marisol
Achillea millefolium
Bioaccessibility
Caco-2 absorption
In vitro digestion
Phenolic compounds
title_short Bioavailability assessment of yarrow phenolic compounds using an in vitro digestion/Caco-2 cell model: Anti-inflammatory activity of basolateral fraction
title_full Bioavailability assessment of yarrow phenolic compounds using an in vitro digestion/Caco-2 cell model: Anti-inflammatory activity of basolateral fraction
title_fullStr Bioavailability assessment of yarrow phenolic compounds using an in vitro digestion/Caco-2 cell model: Anti-inflammatory activity of basolateral fraction
title_full_unstemmed Bioavailability assessment of yarrow phenolic compounds using an in vitro digestion/Caco-2 cell model: Anti-inflammatory activity of basolateral fraction
title_sort Bioavailability assessment of yarrow phenolic compounds using an in vitro digestion/Caco-2 cell model: Anti-inflammatory activity of basolateral fraction
dc.creator.none.fl_str_mv Villalva, Marisol
Jaime, Laura
Siles-Sánchez, María de las Nieves
Santoyo, Susana
author Villalva, Marisol
author_facet Villalva, Marisol
Jaime, Laura
Siles-Sánchez, María de las Nieves
Santoyo, Susana
author_role author
author2 Jaime, Laura
Siles-Sánchez, María de las Nieves
Santoyo, Susana
author2_role author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Comunidad de Madrid
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Achillea millefolium
Bioaccessibility
Caco-2 absorption
In vitro digestion
Phenolic compounds
topic Achillea millefolium
Bioaccessibility
Caco-2 absorption
In vitro digestion
Phenolic compounds
description This article belongs to the Special Issue Natural Polyphenols in Human Health.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/297178
url http://hdl.handle.net/10261/297178
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-110183RB-C22
S2018/BAA-4343/ALIBIRD2020-CM
Molecules
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.3390/molecules27238254
https://doi.org/10.3390/molecules27238254
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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