Chemically Cross-Linked Carbon Nanotube Films Engineered to Control Neuronal Signaling
In recent years, the use of free-standing carbonnanotube (CNT) ?lms for neural tissue engineering has attractedtremendous attention. CNT ?lms show large surface area and highelectrical conductivity that combined with ?exibility and biocompat-ibility may promote neuron growth and di?erentiation while...
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| Format: | article |
| Publication Date: | 2019 |
| Country: | España |
| Institution: | Universidad de Castilla-La Mancha |
| Repository: | RUIdeRA. Repositorio Institucional de la UCLM |
| OAI Identifier: | oai:ruidera.uclm.es:10578/40176 |
| Online Access: | https://doi.org/10.1021/acsnano.9b02429 https://hdl.handle.net/10578/40176 |
| Access Level: | Open access |
| Keyword: | Cross-linking Functionalization degree Neuronal behavior Single-walled carbon nanotube Synaptic activity |
| Summary: | In recent years, the use of free-standing carbonnanotube (CNT) ?lms for neural tissue engineering has attractedtremendous attention. CNT ?lms show large surface area and highelectrical conductivity that combined with ?exibility and biocompat-ibility may promote neuron growth and di?erentiation whilestimulating neural activity. In addition, adhesion, survival, andgrowth of neurons can be modulated through chemical modi?cationof CNTs. Axonal and synaptic signaling can also be positively tunedby these materials. Here we describe the ability of free-standingCNT ?lms to in?uence neuronal activity. We demonstrate that thedegree of cross-linking between the CNTs has a strong impact onthe electrical conductivity of the substrate, which, in turn, regulatesneural circuit outputs. |
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