Antioxidant status and glutathione metabolism in peripheral blood mononuclear cells from patients with chronic hepatitis C

BACKGROUND/AIMS: Oxidative stress could play a role in the pathogenesis of hepatitis C virus infection. We investigated the oxidant/antioxidant status in peripheral blood mononuclear cells from patients with chronic hepatitis C and controls. METHODS/RESULTS: Lipid peroxidation products and superoxid...

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Detalles Bibliográficos
Autores: Boya, P. (Patricia)|||/items/f7ca6760-aa78-4f66-b773-f0b54eec3919, Peña, A. (Andrés) de la|||/items/6df13c84-d55e-42a4-abed-d948b57c98a8, Beloqui, O. (Óscar)|||/items/87d04a14-2d74-4221-8a57-12550777420d, Larrea-Leoz, E. (Esther)|||/items/37a0521f-3293-4001-85d1-bc71241d8a83, Conchillo, M. (M.)|||/items/3b42ee17-2b4a-4804-940b-d8fc8e2c06a3, Castelruiz, Y. (Yurdana)|||/items/6ab82655-ec33-44fc-855e-da085145335b, Civeira, M.P. (María Pilar)|||/items/9aa9621a-63e5-4891-b19c-686ce6f2c29b, Prieto, J. (Jesús)|||/items/0d9c3dec-4a09-400d-8c83-23ece1096c71
Tipo de recurso: artículo
Fecha de publicación:1999
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/23295
Acceso en línea:https://hdl.handle.net/10171/23295
Access Level:acceso abierto
Palabra clave:Antioxidant enzymes
Glutathione
Hepatitis C virus
Malondialdehyde
Oxidative stress
Hepatología
Descripción
Sumario:BACKGROUND/AIMS: Oxidative stress could play a role in the pathogenesis of hepatitis C virus infection. We investigated the oxidant/antioxidant status in peripheral blood mononuclear cells from patients with chronic hepatitis C and controls. METHODS/RESULTS: Lipid peroxidation products and superoxide dismutase activity in peripheral blood mononuclear cells were higher in chronic hepatitis C patients than in healthy subjects while glutathione S-transferase activity was reduced in patients as compared to controls. Catalase, glutathione peroxidase and glutathione reductase were similar in chronic hepatitis C and normal individuals. No statistically significant differences were found between patients and controls with regard to glutathione levels in peripheral blood mononuclear cells, but 35% of patients with chronic hepatitis C showed values of glutathione and oxidized glutathione which were below and above, respectively, the limits of normal controls. Finally, the glutathione synthetic capacity of the cytosol of peripheral blood mononuclear cells was significantly higher in patients than in controls, indicating increased glutathione turnover in lymphocytes from patients with chronic hepatitis C. CONCLUSIONS: Oxidative stress is observed in peripheral blood mononuclear cells from chronic hepatitis C patients. This process might alter lymphocyte function and facilitate the chronicity of the infection.

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