Non-aqueous Titration of Gatifloxacin in Pharmaceutical Formulations using Perchloric Acid
An inexpensive, simple, precise and rapid method for the determination of fluoroquinolone gatifloxacin in tablets is described. The procedure is based on the use of volumetric dosage in a non-aqueous medium in glacial acetic acid with 0.1 M perchloric acid. The method validation yielded good results...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2003 |
| País: | Brasil |
| Institución: | Universidade Estadual Paulista (UNESP) |
| Repositorio: | Repositório Institucional da UNESP |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unesp.br:11449/67436 |
| Acceso en línea: | http://www.latamjpharm.org/trabajos/22/4/LAJOP_22_4_2_1_BME2CBRX6V.pdf http://hdl.handle.net/11449/67436 |
| Access Level: | acceso abierto |
| Palabra clave: | Fluoroquinolone Gatifloxacin Non-aqueous titration Pharmaceutical analysis acetic acid crystal violet excipient gatifloxacin perchloric acid quinoline derived antiinfective agent accuracy analytic method drug determination drug formulation quantitative assay tablet titrimetry validation process weight |
| Sumario: | An inexpensive, simple, precise and rapid method for the determination of fluoroquinolone gatifloxacin in tablets is described. The procedure is based on the use of volumetric dosage in a non-aqueous medium in glacial acetic acid with 0.1 M perchloric acid. The method validation yielded good results and included the precision, recovery and accuracy. It was also found that the excipients in the commercial tablet preparation did not interfere with the assay. |
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