Synthetic tools for the characterization of galactofuranosyl transferases. Glycosylations via acylated glycosyl iodides
With the aim to develop synthetic tools for the characterization of galactofuranosyltransferases, the synthesis of 9-decenyl glycosides of D-Manp, D-Galf and beta-D-Galf-(1,3)-D-Manp was targeted. The interest in the alkenyl aglycone arises from its potential conjugation reactions, once the terminal...
| Autores: | , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2013 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/2105 |
| Acceso en línea: | http://hdl.handle.net/11336/2105 |
| Access Level: | acceso abierto |
| Palabra clave: | Galactofuranosyl Iodides Mannopyranosyl Iodide Per-O-Benzoylated-Galactofuranosyl Iodide Per-O-Tert-Butyldimethylsilyl-B-D Galactofuranose Galactofuranosyl Transferases https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
| Sumario: | With the aim to develop synthetic tools for the characterization of galactofuranosyltransferases, the synthesis of 9-decenyl glycosides of D-Manp, D-Galf and beta-D-Galf-(1,3)-D-Manp was targeted. The interest in the alkenyl aglycone arises from its potential conjugation reactions, once the terminal double bond has been conveniently functionalized. The glycosylation of beta-D-Galf-(1,3)-D-Manp was attempted by two different approaches: the trichloroacetimidate method and the glycosylation via the glycosyl iodide. The conditions for the latter were established on the basis of glycosylation assays of per-Oacetylmannose.On the other hand, the study of glycosylation reactions via per-O-bezoylated galactofuranosyl iodide confirms the versatility of glycosyl iodides as donors. |
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