Thermoresponsive hydrogels from alginate-based graft copolymers
Three samples of sodium alginate grafted by amino-terminated PNIPAM (low and high molecular weight poly(N-isopropylacrylamide)) and a random P(NIPAM-co-NtBAM) (NtBAM: N-tertiary butyl acrylamide) copolymer, were synthesized via the carbodiimide chemistry and their temperature-induced hydrogelation c...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2014 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/25748 |
| Acceso en línea: | http://hdl.handle.net/11336/25748 |
| Access Level: | acceso abierto |
| Palabra clave: | Alginate P(N-Isopropylacrylamide) N-Tert-Butylacrylamide Graft Copolymers https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
| Sumario: | Three samples of sodium alginate grafted by amino-terminated PNIPAM (low and high molecular weight poly(N-isopropylacrylamide)) and a random P(NIPAM-co-NtBAM) (NtBAM: N-tertiary butyl acrylamide) copolymer, were synthesized via the carbodiimide chemistry and their temperature-induced hydrogelation capability was evaluated by rheology. All the samples showed thermothickening behaviour depending on concentration, ionic strength and hydrophobic comonomer content, incorporated to the PNIPAM thermo-sensitive pendant chains. The main result of this study was that a slight hydrophobic enrichment (just 15 mol% NtBAM) of PNIPAM was sufficient to shift the gelation temperature well below the physiological temperature at 32 ºC and at the lowest polymer concentration studied (i.e. 10 wt%). The consequence of that was that the ALG-g- P(NIPAM-co-NtBAM) graft copolymer hydrogel exhibited the best rheological thermo- responsive properties and might be used as injectable hydrogel for potential applications in biomedicine. |
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