Flow injection spectrofluorimetric determination of carvedilol mediated by micelles

A novel flow injection (FI)-spectrofluorimetric methodology for the determination of carvedilol in microheterogeneous medium has been developed. In the sodium dodecyl sulfate (SDS) surfactant medium, an additional fluorescence enhancement was produced by the electrolyte NaCl. A total enhancement of...

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Detalles Bibliográficos
Autores: Silva, Raúl Alejandro, Wang, Chien Chun, Fernandez, Liliana Patricia, Masi, Adriana Noemi
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2008
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/93226
Acceso en línea:http://hdl.handle.net/11336/93226
Access Level:acceso abierto
Palabra clave:CARVEDILOL DETERMINATION
FLOW INJECTION SPECTROFLUORIMETRY
MICELLAR ENHANCEMENT
PHARMACEUTICALS
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
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spelling Flow injection spectrofluorimetric determination of carvedilol mediated by micellesSilva, Raúl AlejandroWang, Chien ChunFernandez, Liliana PatriciaMasi, Adriana NoemiCARVEDILOL DETERMINATIONFLOW INJECTION SPECTROFLUORIMETRYMICELLAR ENHANCEMENTPHARMACEUTICALShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1A novel flow injection (FI)-spectrofluorimetric methodology for the determination of carvedilol in microheterogeneous medium has been developed. In the sodium dodecyl sulfate (SDS) surfactant medium, an additional fluorescence enhancement was produced by the electrolyte NaCl. A total enhancement of 3.1-fold in the native fluorescent response was achieved respect to aqueous medium. Using an excitation and emission wavelength of 286 and 341 nm, respectively, a good linear relationship was obtained in the range of 9 × 10-8 to 1 × 10-6 mol L-1 with a detection limit of 3.63 × 10-9 mol L-1 (S/N = 3). This method was applied to determine carvedilol in commercial pharmaceutical formulations. Good concordance was found between the nominal (6.25, 12.5 and 25.0 mg) and experimental values. The new methodology developed showed high selectivity respect to the common excipients used in pharmaceuticals. The sampling rate was 30 samples h-1. From the fluorescent properties, binding constant for carvedilol-SDS determined was 3.2 × 102 L mol-1.Fil: Silva, Raúl Alejandro. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaFil: Wang, Chien Chun. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaFil: Fernandez, Liliana Patricia. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química. Área de Química Analítica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaFil: Masi, Adriana Noemi. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Laboratorio de Bromatología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaElsevier Science2008-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/93226Silva, Raúl Alejandro; Wang, Chien Chun; Fernandez, Liliana Patricia; Masi, Adriana Noemi; Flow injection spectrofluorimetric determination of carvedilol mediated by micelles; Elsevier Science; Talanta; 76; 1; 6-2008; 166-1710039-9140CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.talanta.2008.02.029info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0039914008001227info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:38:21Zoai:ri.conicet.gov.ar:11336/93226instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:38:21.438CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Flow injection spectrofluorimetric determination of carvedilol mediated by micelles
title Flow injection spectrofluorimetric determination of carvedilol mediated by micelles
spellingShingle Flow injection spectrofluorimetric determination of carvedilol mediated by micelles
Silva, Raúl Alejandro
CARVEDILOL DETERMINATION
FLOW INJECTION SPECTROFLUORIMETRY
MICELLAR ENHANCEMENT
PHARMACEUTICALS
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
title_short Flow injection spectrofluorimetric determination of carvedilol mediated by micelles
title_full Flow injection spectrofluorimetric determination of carvedilol mediated by micelles
title_fullStr Flow injection spectrofluorimetric determination of carvedilol mediated by micelles
title_full_unstemmed Flow injection spectrofluorimetric determination of carvedilol mediated by micelles
title_sort Flow injection spectrofluorimetric determination of carvedilol mediated by micelles
dc.creator.none.fl_str_mv Silva, Raúl Alejandro
Wang, Chien Chun
Fernandez, Liliana Patricia
Masi, Adriana Noemi
author Silva, Raúl Alejandro
author_facet Silva, Raúl Alejandro
Wang, Chien Chun
Fernandez, Liliana Patricia
Masi, Adriana Noemi
author_role author
author2 Wang, Chien Chun
Fernandez, Liliana Patricia
Masi, Adriana Noemi
author2_role author
author
author
dc.subject.none.fl_str_mv CARVEDILOL DETERMINATION
FLOW INJECTION SPECTROFLUORIMETRY
MICELLAR ENHANCEMENT
PHARMACEUTICALS
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
topic CARVEDILOL DETERMINATION
FLOW INJECTION SPECTROFLUORIMETRY
MICELLAR ENHANCEMENT
PHARMACEUTICALS
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
description A novel flow injection (FI)-spectrofluorimetric methodology for the determination of carvedilol in microheterogeneous medium has been developed. In the sodium dodecyl sulfate (SDS) surfactant medium, an additional fluorescence enhancement was produced by the electrolyte NaCl. A total enhancement of 3.1-fold in the native fluorescent response was achieved respect to aqueous medium. Using an excitation and emission wavelength of 286 and 341 nm, respectively, a good linear relationship was obtained in the range of 9 × 10-8 to 1 × 10-6 mol L-1 with a detection limit of 3.63 × 10-9 mol L-1 (S/N = 3). This method was applied to determine carvedilol in commercial pharmaceutical formulations. Good concordance was found between the nominal (6.25, 12.5 and 25.0 mg) and experimental values. The new methodology developed showed high selectivity respect to the common excipients used in pharmaceuticals. The sampling rate was 30 samples h-1. From the fluorescent properties, binding constant for carvedilol-SDS determined was 3.2 × 102 L mol-1.
publishDate 2008
dc.date.none.fl_str_mv 2008-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/93226
Silva, Raúl Alejandro; Wang, Chien Chun; Fernandez, Liliana Patricia; Masi, Adriana Noemi; Flow injection spectrofluorimetric determination of carvedilol mediated by micelles; Elsevier Science; Talanta; 76; 1; 6-2008; 166-171
0039-9140
CONICET Digital
CONICET
url http://hdl.handle.net/11336/93226
identifier_str_mv Silva, Raúl Alejandro; Wang, Chien Chun; Fernandez, Liliana Patricia; Masi, Adriana Noemi; Flow injection spectrofluorimetric determination of carvedilol mediated by micelles; Elsevier Science; Talanta; 76; 1; 6-2008; 166-171
0039-9140
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.talanta.2008.02.029
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0039914008001227
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 15,812429

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