Molecular accuracy vs antigenic speed: SARS-CoV-2 testing strategies

The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has hit every corner of the world faster than any infectious disease ever known. In this context, rapid and accurate testing of positive cases are essential to follow the test-trace-isolate strategy (TETRIS), whi...

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Detalles Bibliográficos
Autores: Fajardo, Álvaro, Perbolianachis, Paula, Ferreiro, Irene, Moreno, Pilar, Moratorio, Gonzalo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:Uruguay
Institución:Institut Pasteur de Montevideo
Repositorio:IPMON en REDI
Idioma:inglés
OAI Identifier:oai:redi.anii.org.uy:20.500.12381/3466
Acceso en línea:https://hdl.handle.net/20.500.12381/3466
https://doi.org/10.1016/j.coph.2021.12.006
Access Level:acceso abierto
Palabra clave:SARS-CoV-2
Testing strategies
RT-PCR
Antigenic test
Ciencias Naturales y Exactas
Ciencias Biológicas
Virología
Descripción
Sumario:The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has hit every corner of the world faster than any infectious disease ever known. In this context, rapid and accurate testing of positive cases are essential to follow the test-trace-isolate strategy (TETRIS), which has proven to be a key approach to constrain viral spread. Here, we discuss how to interpret and combine molecular or/and antigen-based detection methods for SARS-CoV-2 as well as when they should be used. Their application can be cleverly designed as an algorithm to prevent viral dissemination according to distinct epidemiological contexts within surveillance programs.