E-Cadherin gene expression in oral cancer : Clinical and prospective data

Low protein expression of E-cadherin in oral squamous cell carcinoma (OSCC) has been associated with clinical and histopathological traits such as metastases, recurrence, low survival and poor tumor differentiation, and it is considered a high-risk marker of malignancy. However, it is still unknown...

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Bibliographic Details
Authors: López-Verdín, Sandra, de la Luz Martínez-Fierro, Margarita, Garza-Veloz, Idalia, Zamora Pérez, Ana Lourdes, Grajeda-Cruz, Jonathan, González González, Rogelio, Molina-Frechero, Nelly, Arocena, Miguel, Bologna-Molina, Ronell
Format: article
Status:Published version
Publication Date:2019
Country:Uruguay
Institution:Universidad de la República
Repository:COLIBRI
Language:English
OAI Identifier:oai:colibri.udelar.edu.uy:20.500.12008/25951
Online Access:https://hdl.handle.net/20.500.12008/25951
https://doi.org/10.4317/medoral.23029
Access Level:Open access
Keyword:Oral cancer
E-Cadherin
Gene expression
Description
Summary:Low protein expression of E-cadherin in oral squamous cell carcinoma (OSCC) has been associated with clinical and histopathological traits such as metastases, recurrence, low survival and poor tumor differentiation, and it is considered a high-risk marker of malignancy. However, it is still unknown whether low expression of E-cadherin is also present at the mRNA level in OSCC cases. Objective: The aim of this study was to compare E-cadherin mRNA expression in OSCC patients and controls and to correlate the expression with clinical and prospective characteristics.

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