E-Cadherin gene expression in oral cancer : Clinical and prospective data

Low protein expression of E-cadherin in oral squamous cell carcinoma (OSCC) has been associated with clinical and histopathological traits such as metastases, recurrence, low survival and poor tumor differentiation, and it is considered a high-risk marker of malignancy. However, it is still unknown...

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Detalles Bibliográficos
Autores: López-Verdín, Sandra, de la Luz Martínez-Fierro, Margarita, Garza-Veloz, Idalia, Zamora Pérez, Ana Lourdes, Grajeda-Cruz, Jonathan, González González, Rogelio, Molina-Frechero, Nelly, Arocena, Miguel, Bologna-Molina, Ronell
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:Uruguay
Institución:Universidad de la República
Repositorio:COLIBRI
Idioma:inglés
OAI Identifier:oai:colibri.udelar.edu.uy:20.500.12008/25951
Acceso en línea:https://hdl.handle.net/20.500.12008/25951
https://doi.org/10.4317/medoral.23029
Access Level:acceso abierto
Palabra clave:Oral cancer
E-Cadherin
Gene expression
Descripción
Sumario:Low protein expression of E-cadherin in oral squamous cell carcinoma (OSCC) has been associated with clinical and histopathological traits such as metastases, recurrence, low survival and poor tumor differentiation, and it is considered a high-risk marker of malignancy. However, it is still unknown whether low expression of E-cadherin is also present at the mRNA level in OSCC cases. Objective: The aim of this study was to compare E-cadherin mRNA expression in OSCC patients and controls and to correlate the expression with clinical and prospective characteristics.

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