Differences in Childhood Growth Parameters Between Patients With Somatic and Heritable Retinoblastoma

PURPOSE. Little is known regarding differences in childhood growth between somatic and heritable retinoblastoma (Rb) populations. We aimed to compare childhood growth parameters between somatic and heritable Rb cohorts at birth and at time of diagnosis with Rb. METHODS. A multinational, longitudinal...

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Autores: Hicks, RM, Ji, X, Zou, Y, Sultana, S, Rashid, R, Sherief, ST, Cassoux, N, Garcia, Leon, JL, Diaz, Coronado, RY, López, AMZ, Ushakova, TL, Polyakov, VG, Roy, SR, Ahmad, A, Reddy, MA, Sagoo, MS, Harby, LA, Berry, JL, Polski, A, Astbury, NJ, Bascaran, C, Blum, S, Bowman, R, Burton, MJ, Gomel, N, Keren-Froim, N, Madgar, S, Zondervan, M, Kaliki, S, Fabian, ID, Stacey, AW
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:Perú
Institución:Instituto Nacional de Enfermedades Neoplásicas
Repositorio:INEN-Institucional
Idioma:inglés
OAI Identifier:oai:repositorio.inen.sld.pe:20.500.14703/369
Acceso en línea:https://hdl.handle.net/20.500.14703/369
Access Level:acceso abierto
Palabra clave:childhood growth
failure to thrive
germline
growth parameters
retinoblastoma
https://purl.org/pe-repo/ocde/ford#3.02.21
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spelling Publication2025-04-25T17:29:32Z2025-04-25T17:29:32Z202410.1167/IOVS.65.4.39https://hdl.handle.net/20.500.14703/369Investigative Ophthalmology and Visual SciencePURPOSE. Little is known regarding differences in childhood growth between somatic and heritable retinoblastoma (Rb) populations. We aimed to compare childhood growth parameters between somatic and heritable Rb cohorts at birth and at time of diagnosis with Rb. METHODS. A multinational, longitudinal cohort study was conducted with patients from 11 centers in 10 countries who presented with treatment naïve Rb from January to December 2019. Variables of interest included age, sex, and size characteristics at birth and at time of presentation, as well as germline mutation status. After Bonferroni correction, results were statistically significant if the P value was less than 0.005. RESULTS. We enrolled 696 patients, with 253 analyzed after exclusion criteria applied. Between somatic (n = 39) and heritable (n = 214) Rb cohorts, with males and females analyzed separately, there was no significant difference in birth weight percentile, weight percentile at time of diagnosis, length percentile at time of diagnosis, weight-for-length percentile at time of diagnosis, or change of weight percentile from birth to time of diagnosis. Patients with heritable Rb had a smaller mean weight percentile at birth and smaller mean weight and length percentiles at time of diagnosis with Rb, although this difference was not statistically significant. All cohorts experienced a slight negative change of weight percentile from birth to time of diagnosis. No cohort mean percentiles met criteria for failure to thrive, defined as less than the 5th percentile. CONCLUSIONS. Children with Rb seem to have normal birth and childhood growth patterns. There is no definitive evidence that somatic or heritable Rb has a biological or environmental impact on childhood growth parameters. © 2024 Association for Research in Vision and Ophthalmology Inc.. All rights reserved.application/pdfengAssociation for Research in Vision and Ophthalmology Inc.USinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/4.0/childhood growthfailure to thrivegermlinegrowth parametersretinoblastomahttps://purl.org/pe-repo/ocde/ford#3.02.21Differences in Childhood Growth Parameters Between Patients With Somatic and Heritable Retinoblastomainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionreponame:INEN-Institucionalinstname:Instituto Nacional de Enfermedades Neoplásicasinstacron:INENHicks, RMJi, XZou, YSultana, SRashid, RSherief, STCassoux, NGarcia, Leon, JLDiaz, Coronado, RYLópez, AMZUshakova, TLPolyakov, VGRoy, SRAhmad, AReddy, MASagoo, MSHarby, LABerry, JLPolski, AAstbury, NJBascaran, CBlum, SBowman, RBurton, MJGomel, NKeren-Froim, NMadgar, SZondervan, MKaliki, SFabian, IDStacey, AW20.500.14703/369oai:repositorio.inen.sld.pe:20.500.14703/3692026-02-15 11:48:05.489https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessmetadata.onlyhttps://repositorio.inen.sld.peRepositorio Institucional INENrepositorio@inen.sld.pe
dc.title.none.fl_str_mv Differences in Childhood Growth Parameters Between Patients With Somatic and Heritable Retinoblastoma
title Differences in Childhood Growth Parameters Between Patients With Somatic and Heritable Retinoblastoma
spellingShingle Differences in Childhood Growth Parameters Between Patients With Somatic and Heritable Retinoblastoma
Hicks, RM
childhood growth
failure to thrive
germline
growth parameters
retinoblastoma
https://purl.org/pe-repo/ocde/ford#3.02.21
title_short Differences in Childhood Growth Parameters Between Patients With Somatic and Heritable Retinoblastoma
title_full Differences in Childhood Growth Parameters Between Patients With Somatic and Heritable Retinoblastoma
title_fullStr Differences in Childhood Growth Parameters Between Patients With Somatic and Heritable Retinoblastoma
title_full_unstemmed Differences in Childhood Growth Parameters Between Patients With Somatic and Heritable Retinoblastoma
title_sort Differences in Childhood Growth Parameters Between Patients With Somatic and Heritable Retinoblastoma
dc.creator.none.fl_str_mv Hicks, RM
Ji, X
Zou, Y
Sultana, S
Rashid, R
Sherief, ST
Cassoux, N
Garcia, Leon, JL
Diaz, Coronado, RY
López, AMZ
Ushakova, TL
Polyakov, VG
Roy, SR
Ahmad, A
Reddy, MA
Sagoo, MS
Harby, LA
Berry, JL
Polski, A
Astbury, NJ
Bascaran, C
Blum, S
Bowman, R
Burton, MJ
Gomel, N
Keren-Froim, N
Madgar, S
Zondervan, M
Kaliki, S
Fabian, ID
Stacey, AW
author Hicks, RM
author_facet Hicks, RM
Ji, X
Zou, Y
Sultana, S
Rashid, R
Sherief, ST
Cassoux, N
Garcia, Leon, JL
Diaz, Coronado, RY
López, AMZ
Ushakova, TL
Polyakov, VG
Roy, SR
Ahmad, A
Reddy, MA
Sagoo, MS
Harby, LA
Berry, JL
Polski, A
Astbury, NJ
Bascaran, C
Blum, S
Bowman, R
Burton, MJ
Gomel, N
Keren-Froim, N
Madgar, S
Zondervan, M
Kaliki, S
Fabian, ID
Stacey, AW
author_role author
author2 Ji, X
Zou, Y
Sultana, S
Rashid, R
Sherief, ST
Cassoux, N
Garcia, Leon, JL
Diaz, Coronado, RY
López, AMZ
Ushakova, TL
Polyakov, VG
Roy, SR
Ahmad, A
Reddy, MA
Sagoo, MS
Harby, LA
Berry, JL
Polski, A
Astbury, NJ
Bascaran, C
Blum, S
Bowman, R
Burton, MJ
Gomel, N
Keren-Froim, N
Madgar, S
Zondervan, M
Kaliki, S
Fabian, ID
Stacey, AW
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv childhood growth
failure to thrive
germline
growth parameters
retinoblastoma
topic childhood growth
failure to thrive
germline
growth parameters
retinoblastoma
https://purl.org/pe-repo/ocde/ford#3.02.21
dc.subject.ocde.none.fl_str_mv https://purl.org/pe-repo/ocde/ford#3.02.21
description PURPOSE. Little is known regarding differences in childhood growth between somatic and heritable retinoblastoma (Rb) populations. We aimed to compare childhood growth parameters between somatic and heritable Rb cohorts at birth and at time of diagnosis with Rb. METHODS. A multinational, longitudinal cohort study was conducted with patients from 11 centers in 10 countries who presented with treatment naïve Rb from January to December 2019. Variables of interest included age, sex, and size characteristics at birth and at time of presentation, as well as germline mutation status. After Bonferroni correction, results were statistically significant if the P value was less than 0.005. RESULTS. We enrolled 696 patients, with 253 analyzed after exclusion criteria applied. Between somatic (n = 39) and heritable (n = 214) Rb cohorts, with males and females analyzed separately, there was no significant difference in birth weight percentile, weight percentile at time of diagnosis, length percentile at time of diagnosis, weight-for-length percentile at time of diagnosis, or change of weight percentile from birth to time of diagnosis. Patients with heritable Rb had a smaller mean weight percentile at birth and smaller mean weight and length percentiles at time of diagnosis with Rb, although this difference was not statistically significant. All cohorts experienced a slight negative change of weight percentile from birth to time of diagnosis. No cohort mean percentiles met criteria for failure to thrive, defined as less than the 5th percentile. CONCLUSIONS. Children with Rb seem to have normal birth and childhood growth patterns. There is no definitive evidence that somatic or heritable Rb has a biological or environmental impact on childhood growth parameters. © 2024 Association for Research in Vision and Ophthalmology Inc.. All rights reserved.
publishDate 2024
dc.date.accessioned.none.fl_str_mv 2025-04-25T17:29:32Z
dc.date.available.none.fl_str_mv 2025-04-25T17:29:32Z
dc.date.issued.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.doi.none.fl_str_mv 10.1167/IOVS.65.4.39
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.14703/369
dc.identifier.journal.none.fl_str_mv Investigative Ophthalmology and Visual Science
identifier_str_mv 10.1167/IOVS.65.4.39
Investigative Ophthalmology and Visual Science
url https://hdl.handle.net/20.500.14703/369
dc.language.iso.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.uri.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Association for Research in Vision and Ophthalmology Inc.
dc.publisher.country.none.fl_str_mv US
publisher.none.fl_str_mv Association for Research in Vision and Ophthalmology Inc.
dc.source.none.fl_str_mv reponame:INEN-Institucional
instname:Instituto Nacional de Enfermedades Neoplásicas
instacron:INEN
instname_str Instituto Nacional de Enfermedades Neoplásicas
instacron_str INEN
institution INEN
reponame_str INEN-Institucional
collection INEN-Institucional
repository.name.fl_str_mv Repositorio Institucional INEN
repository.mail.fl_str_mv repositorio@inen.sld.pe
_version_ 1863016468152582144
score 15,812429

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