Tuberculosis incidence in patients with psoriasis who receive anti- TNF- alpha therapies in Latin America: systematic review and meta-analysis
The global incidence of tuberculosis in patients with psoriasis who receive anti- tumoral necrosis factor (TNF)- alpha in Latin America remains unknown, despite of the increasing use of those therapies and the local high incidences of tuberculosis, so a systematic review and meta-analysis on the sub...
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | Perú |
| Institución: | Universidad Nacional Mayor de San Marcos |
| Repositorio: | Revistas - Universidad Nacional Mayor de San Marcos |
| Idioma: | español |
| OAI Identifier: | oai:revistasinvestigacion.unmsm.edu.pe:article/15881 |
| Acceso en línea: | https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/15881 |
| Access Level: | acceso abierto |
| Palabra clave: | Tuberculosis Psoriasis Etanercept Infliximab Adalimumab |
| Sumario: | The global incidence of tuberculosis in patients with psoriasis who receive anti- tumoral necrosis factor (TNF)- alpha in Latin America remains unknown, despite of the increasing use of those therapies and the local high incidences of tuberculosis, so a systematic review and meta-analysis on the subject was carried out. For that review, there were included studies reporting the tuberculosis incidence in patients with psoriasis receiving anti- TNF- alpha in Latin America, using four electronical databases: Pubmed, Scielo, LILACS and Medigraphic, and then to perform a meta-analysis about those incidences in order to obtain pooled proportions. Finally, 9 studies were selected, which were performed in Argentina, Brasil, Chile, Colombia and México, with a total follow-up of 510,9 patient-years, and with three cases of tuberculosis, giving a pooled incidence of 636 cases of tuberculosis per 100,000 patient-years (95% confidence interval [CI 95%]: 145-1764 per 100,000 patient-years), after using the fixed effects model, which was high according to the stimates of the regional population- based tuberculosis incidence, and similar to other studies performed in patients with psoriasis who receive anti- TNF- alpha in different locations. |
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