Bilinear Acute Monocytic Leukemia/B BCR ABL positive. presentation of a case
Background: Leukemias with an ambiguous phenotype are classified as undifferentiated leukemias and mixed phenotypes, these in turn can be divided into bilinear or biphenotypic and are usually associated with a poor prognosis, especially if they are accompanied by aggressive translocations such as th...
| Authors: | , , |
|---|---|
| Format: | article |
| Status: | Published version |
| Publication Date: | 2023 |
| Country: | Perú |
| Institution: | Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo |
| Repository: | Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo |
| Language: | Spanish |
| OAI Identifier: | oai:cmhnaaa_ojs_cmhnaaa.cmhnaaa.org.pe:article/1820 |
| Online Access: | https://cmhnaaa.org.pe/ojs/index.php/rcmhnaaa/article/view/1820 |
| Access Level: | Open access |
| Keyword: | Leucemia de Células B Leucemia Mieloide Aguda Leucemia-Linfoma Linfoblástico de Células Precursoras B Leucemia Monocítica Aguda Leukemia, B-Cell Leukemia, Myeloid, Acute Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Leukemia, Monocytic, Acute |
| Summary: | Background: Leukemias with an ambiguous phenotype are classified as undifferentiated leukemias and mixed phenotypes, these in turn can be divided into bilinear or biphenotypic and are usually associated with a poor prognosis, especially if they are accompanied by aggressive translocations such as the Philadelphia chromosome. Case report: We present the case of an elderly adult patient who presented acute bilinear leukemia with the presence of a population of monoblastic lineage precursors and another, B lymphoid, evaluated by flow cytometry studies, who also presented the BCR-ABL transcript. , detected by real-time PCR studies. The patient had a poor evolution and died 11 days after her diagnosis. Conclusion: Mixed phenotype leukemias have a poor prognosis and require early diagnosis by flow cytometry and molecular biology to provide timely treatment. |
|---|