Bilinear Acute Monocytic Leukemia/B BCR ABL positive. presentation of a case
Background: Leukemias with an ambiguous phenotype are classified as undifferentiated leukemias and mixed phenotypes, these in turn can be divided into bilinear or biphenotypic and are usually associated with a poor prognosis, especially if they are accompanied by aggressive translocations such as th...
| Autores: | , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | Perú |
| Recursos: | Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo |
| Repositorio: | Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo |
| Idioma: | español |
| OAI Identifier: | oai:cmhnaaa_ojs_cmhnaaa.cmhnaaa.org.pe:article/1820 |
| Acesso em linha: | https://cmhnaaa.org.pe/ojs/index.php/rcmhnaaa/article/view/1820 |
| Access Level: | acceso abierto |
| Palavra-chave: | Leucemia de Células B Leucemia Mieloide Aguda Leucemia-Linfoma Linfoblástico de Células Precursoras B Leucemia Monocítica Aguda Leukemia, B-Cell Leukemia, Myeloid, Acute Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Leukemia, Monocytic, Acute |
| Resumo: | Background: Leukemias with an ambiguous phenotype are classified as undifferentiated leukemias and mixed phenotypes, these in turn can be divided into bilinear or biphenotypic and are usually associated with a poor prognosis, especially if they are accompanied by aggressive translocations such as the Philadelphia chromosome. Case report: We present the case of an elderly adult patient who presented acute bilinear leukemia with the presence of a population of monoblastic lineage precursors and another, B lymphoid, evaluated by flow cytometry studies, who also presented the BCR-ABL transcript. , detected by real-time PCR studies. The patient had a poor evolution and died 11 days after her diagnosis. Conclusion: Mixed phenotype leukemias have a poor prognosis and require early diagnosis by flow cytometry and molecular biology to provide timely treatment. |
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