Acetaminophen-DNA nitrogenous bases interaction, an electrochemical study
The interaction of acetaminophen with the purine bases of DNA (guanine and adenine) is exposed for the first time. The study of the interaction was carried out through differential pulse voltammetry (VDP), there are not interference between acetaminophen, guanine (G) and adenine (A), so they can be...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | México |
| Institución: | UNIVERSIDAD AUTÓNOMA DEL ESTADO DE HIDALGO |
| Repositorio: | PÄDI Boletín Científico de Ciencias Básicas e Ingeniería del ICBI |
| Idioma: | español |
| OAI Identifier: | oai:repository.uaeh.edu.mx:article/10341 |
| Acceso en línea: | https://repository.uaeh.edu.mx/revistas/index.php/icbi/article/view/10341 |
| Access Level: | acceso abierto |
| Palabra clave: | acetaminophen guanine adenine dna damage acetaminofén guanina adenina interacción fármaco |
| Sumario: | The interaction of acetaminophen with the purine bases of DNA (guanine and adenine) is exposed for the first time. The study of the interaction was carried out through differential pulse voltammetry (VDP), there are not interference between acetaminophen, guanine (G) and adenine (A), so they can be analysed independently. The effect of the drug concentration was analysed from current and potential changes, as indicative of possible alterations in the bases, a significant decrease in the current of G and A was observed. In addition, interaction with oxidation product of acetaminophen, N-acetyl-para-benzoquinoneimine, was analysed through production in situ by electrodeposition of the oxidized species of the drug. the results show a damage on G and A induced by the exposure to the product of oxidative degradation, where the most affected base is adenine. |
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