Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine. Evidence of the guanine adduct formation
The electrochemical behavior of the interaction of amodiaquine with DNA on a carbon paste electrode was studied using voltametric techniques. In an acid medium, an electroactive adduct is formed when amodiaquine interacts with DNA. The anodic peak is dependent on pH, scan rate and the concentration...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2010 |
| País: | Brasil |
| Institución: | Universidade Federal de Mato Grosso do Sul (UFMS) |
| Repositorio: | Repositório Institucional da UFMS |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.ufms.br:123456789/768 |
| Acceso en línea: | https://repositorio.ufms.br/handle/123456789/768 http://dx.doi.org/10.1590/S0100-40422010000600014 |
| Access Level: | acceso abierto |
| Palabra clave: | Amodiaquina Guanina Adutos do DNA Amodiaquine Guanine DNA Adducts |
| Sumario: | The electrochemical behavior of the interaction of amodiaquine with DNA on a carbon paste electrode was studied using voltametric techniques. In an acid medium, an electroactive adduct is formed when amodiaquine interacts with DNA. The anodic peak is dependent on pH, scan rate and the concentration of the pharmaceutical. Adduct formation is irreversible in nature, and preferentially occurs by interaction of the amodiaquine with the guanine group. Theoretical calculations for optimization of geometry, and DFT analyses and on the electrostatic potential map (EPM), were used in the investigation of adduct formation between amodiaquine and DNA. |
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