Orbitofrontal Cortex Inactivation Impairs Early Reversal Learning in Male Rats During a Sexually Motivated Task

This study analyzes whether inactivation of the orbitofrontal cortex (OFC) affects early discrimination or reversal learning during a T maze motivated task. Male rats received salinesolution or one doses of tetrodotoxin (TTX) bilaterally into the OFC, and were permitted to have an intromission with...

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Authors: Miguel Angel Guevara Pérez, Francisco Abelardo Robles Aguirre, Gina Lorena Quirarte, Marisela Hernández González
Format: article
Status:Published version
Publication Date:2009
Country:México
Institution:Universidad Nacional Autónoma de México
Repository:Redalyc-UNAM
OAI Identifier:oai:redalyc.org:56012878001
Online Access:https://www.redalyc.org/articulo.oa?id=56012878001
Access Level:Open access
Keyword:Psicología
T maze
tetrodotoxin
reversal learning
sexual motivation
Orbitofrontal cortex
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spelling Orbitofrontal Cortex Inactivation Impairs Early Reversal Learning in Male Rats During a Sexually Motivated TaskMiguel Angel Guevara PérezFrancisco Abelardo Robles AguirreGina Lorena QuirarteMarisela Hernández GonzálezPsicologíaT mazetetrodotoxinreversal learningsexual motivationOrbitofrontal cortexThis study analyzes whether inactivation of the orbitofrontal cortex (OFC) affects early discrimination or reversal learning during a T maze motivated task. Male rats received salinesolution or one doses of tetrodotoxin (TTX) bilaterally into the OFC, and were permitted to have an intromission with a receptive female to induce a sexually motivated state. Discrimination and reversal sessions consisted of seven trials each to accomplish the non-overtrained condition. Each arm of the T maze was associated to different external cues. Subjects were sexually reinforced whenever they reached the receptive female box, and returned to the start-box if not. Spontaneous motor activity was not altered. Rats with OFC inactivated did not present alteration during discrimination. Males with higher doses of TTX had a deficit in the number of correct responses and increased number of trials without response during reversal learning. These data agrees with other studies and indicates that an intact OFC is essential for the adequate manifestation of reversal learning during its early phase in motivated tasks. However, disagrees with other findings about early perseverative responses, pointing out to a critical role of this structure in enhancing performance through incentive value re-assignment of predicted outcome cues.Universidad de Almería2009info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdf1577-7057https://www.redalyc.org/articulo.oa?id=56012878001International Journal of Psychology and Psychological Therapy (España) Num.2 Vol.9reponame:Redalyc-UNAMinstname:Universidad Nacional Autónoma de Méxicoinstacron:UNAMenhttp://www.redalyc.org/revista.oa?id=560International Journal of Psychology and Psychological Therapyinfo:eu-repo/semantics/openAccessoai:redalyc.org:560128780012025-09-03T18:06:06Z
dc.title.none.fl_str_mv Orbitofrontal Cortex Inactivation Impairs Early Reversal Learning in Male Rats During a Sexually Motivated Task
title Orbitofrontal Cortex Inactivation Impairs Early Reversal Learning in Male Rats During a Sexually Motivated Task
spellingShingle Orbitofrontal Cortex Inactivation Impairs Early Reversal Learning in Male Rats During a Sexually Motivated Task
Miguel Angel Guevara Pérez
Psicología
T maze
tetrodotoxin
reversal learning
sexual motivation
Orbitofrontal cortex
title_short Orbitofrontal Cortex Inactivation Impairs Early Reversal Learning in Male Rats During a Sexually Motivated Task
title_full Orbitofrontal Cortex Inactivation Impairs Early Reversal Learning in Male Rats During a Sexually Motivated Task
title_fullStr Orbitofrontal Cortex Inactivation Impairs Early Reversal Learning in Male Rats During a Sexually Motivated Task
title_full_unstemmed Orbitofrontal Cortex Inactivation Impairs Early Reversal Learning in Male Rats During a Sexually Motivated Task
title_sort Orbitofrontal Cortex Inactivation Impairs Early Reversal Learning in Male Rats During a Sexually Motivated Task
dc.creator.none.fl_str_mv Miguel Angel Guevara Pérez
Francisco Abelardo Robles Aguirre
Gina Lorena Quirarte
Marisela Hernández González
author Miguel Angel Guevara Pérez
author_facet Miguel Angel Guevara Pérez
Francisco Abelardo Robles Aguirre
Gina Lorena Quirarte
Marisela Hernández González
author_role author
author2 Francisco Abelardo Robles Aguirre
Gina Lorena Quirarte
Marisela Hernández González
author2_role author
author
author
dc.subject.none.fl_str_mv Psicología
T maze
tetrodotoxin
reversal learning
sexual motivation
Orbitofrontal cortex
topic Psicología
T maze
tetrodotoxin
reversal learning
sexual motivation
Orbitofrontal cortex
description This study analyzes whether inactivation of the orbitofrontal cortex (OFC) affects early discrimination or reversal learning during a T maze motivated task. Male rats received salinesolution or one doses of tetrodotoxin (TTX) bilaterally into the OFC, and were permitted to have an intromission with a receptive female to induce a sexually motivated state. Discrimination and reversal sessions consisted of seven trials each to accomplish the non-overtrained condition. Each arm of the T maze was associated to different external cues. Subjects were sexually reinforced whenever they reached the receptive female box, and returned to the start-box if not. Spontaneous motor activity was not altered. Rats with OFC inactivated did not present alteration during discrimination. Males with higher doses of TTX had a deficit in the number of correct responses and increased number of trials without response during reversal learning. These data agrees with other studies and indicates that an intact OFC is essential for the adequate manifestation of reversal learning during its early phase in motivated tasks. However, disagrees with other findings about early perseverative responses, pointing out to a critical role of this structure in enhancing performance through incentive value re-assignment of predicted outcome cues.
publishDate 2009
dc.date.none.fl_str_mv 2009
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 1577-7057
https://www.redalyc.org/articulo.oa?id=56012878001
identifier_str_mv 1577-7057
url https://www.redalyc.org/articulo.oa?id=56012878001
dc.language.none.fl_str_mv en
language_invalid_str_mv en
dc.relation.none.fl_str_mv http://www.redalyc.org/revista.oa?id=560
dc.rights.none.fl_str_mv International Journal of Psychology and Psychological Therapy
info:eu-repo/semantics/openAccess
rights_invalid_str_mv International Journal of Psychology and Psychological Therapy
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad de Almería
publisher.none.fl_str_mv Universidad de Almería
dc.source.none.fl_str_mv International Journal of Psychology and Psychological Therapy (España) Num.2 Vol.9
reponame:Redalyc-UNAM
instname:Universidad Nacional Autónoma de México
instacron:UNAM
instname_str Universidad Nacional Autónoma de México
instacron_str UNAM
institution UNAM
reponame_str Redalyc-UNAM
collection Redalyc-UNAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 14.964248

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