Orbitofrontal Ensemble Activity Monitors Licking and Distinguishes Among Natural Rewards
In this study, we investigated the relationship between OFC activity and licking clusters by inactivating the OFC using muscimol, a GABA agonist, and by analyzing the activity of neuronal ensembles in the OFC obtained from freely licking rats. For the following reasons, we used chronic, multielectro...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2006 |
| País: | España |
| Institución: | Universidad Católica de Valencia San Vicente Mártir |
| Repositorio: | RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir |
| Idioma: | inglés |
| OAI Identifier: | oai:riucv.ucv.es:20.500.12466/7017 |
| Acceso en línea: | https://hdl.handle.net/20.500.12466/7017 |
| Access Level: | acceso abierto |
| Palabra clave: | Orbitofrontal cortex Orbitofrontal neurons Licking clusters Neuronal ensembles Rats 32 Ciencias Médicas |
| Sumario: | In this study, we investigated the relationship between OFC activity and licking clusters by inactivating the OFC using muscimol, a GABA agonist, and by analyzing the activity of neuronal ensembles in the OFC obtained from freely licking rats. For the following reasons, we used chronic, multielectrode recording techniques to record from ensembles of OFC neurons. First, because licking involves the integration of chemosensory, motor and motivational responses, and neuronal ensemble recordings allow us to describe the full diversity of individual neuronal responses that occur simultaneously. Second, OFC neuronal ensembles offer a better alternative than single neuron recordings at predicting a behavioral event in a single trial basis (Cohen and Nicolelis 2004). A similar approach has been successfully used in the motor and somatosensory system (Carmena et al.2003; Costa et al. 2004; Foffani and Moxon 2004; Ghazanfar et al. 2000; Laubach et al. 2000; Narayanan et al. 2005; Wessberg et al. 2000). However, to our knowledge, only a few studies have reported the ensemble activity of orbitofrontal neurons (Schoenbaum and Eichenbaum 1995b). |
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