Antibacterial behavior of chitosan-sodium hyaluronate-PEGDE crosslinked films

Chitosan is a natural polymer that can sustain not only osteoblast adhesion and proliferation for bone regeneration purposes, but it is also claimed to exhibit antibacterial properties towards several Gram-positive and Gram-negative bacteria. In this study, chitosan was modified with sodium hyaluron...

Descripción completa

Detalles Bibliográficos
Autores: Martha Gabriela Chuc-Gamboa, Carolina María Cámara Perera, Fernando Javier Aguilar-Ayala, ROSSANA FARIDE VARGAS CORONADO, JUAN VALERIO CAUICH RODRIGUEZ, DIANA MARIA ESCOBAR GARCIA, Luis Octavio Sanchez Vargas, Neith Pacheco López, Julio San Roman Del Barrio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:México
Institución:Centro de Investigación Científica de Yucatán
Repositorio:Repositorio Institucional CICY
Idioma:inglés
OAI Identifier:oai:cicy.repositorioinstitucional.mx:1003/2138
Acceso en línea:http://cicy.repositorioinstitucional.mx/jspui/handle/1003/2138
Access Level:acceso abierto
Palabra clave:info:eu-repo/classification/Autores/CHITOSAN
info:eu-repo/classification/Autores/SODIUM HYALURONATE
info:eu-repo/classification/Autores/PEGDE
info:eu-repo/classification/Autores/ANTIBACTERIAL
info:eu-repo/classification/Autores/ESCHERICHIA COLI
info:eu-repo/classification/Autores/ENTEROCOCCUS FAECALIS
info:eu-repo/classification/Autores/STAPHYLOCOCCUS AUREUS
info:eu-repo/classification/Autores/SALMONELLA TYPHIMURION
info:eu-repo/classification/cti/7
info:eu-repo/classification/cti/33
info:eu-repo/classification/cti/3312
info:eu-repo/classification/cti/331208
Descripción
Sumario:Chitosan is a natural polymer that can sustain not only osteoblast adhesion and proliferation for bone regeneration purposes, but it is also claimed to exhibit antibacterial properties towards several Gram-positive and Gram-negative bacteria. In this study, chitosan was modified with sodium hyaluronate, crosslinked with polyethylene glycol diglycidyl ether (PEGDE) and both osteoblast cytotoxicity and antibacterial behavior studied. The presence of sodium hyaluronate and PEGDE on chitosan was detected by FTIR, XRD, and XPS. Chitosan (CHT) films with sodium hyaluronate crosslinked with PEGDE showed a better thermal stability than pristine hyaluronate. In addition, osteoblast cytocompatibility improved in films containing sodium hyaluronate. However, none of the films exhibit antimicrobial activity against Escherichia coli, Enterococcus faecalis, and Staphylococcus aureus while exhibiting low to mild activity against Salmonella typhimurion.

Similares en LA Referencia