Bovine Interferon-Tau Activates Type I interferon-Associated Janus-signal Transducer in HPV16-positive Tumor Cell

Abstract The mechanisms of signal transduction by interferon-tau (IFN-τ) are widely known during the gestation of ruminants. In trophoblast cells, IFN-τ involves the activation of the JAK-STAT pathway, and it can have effects on other cell types, such as tumor cells. Here we report that the HPV16-po...

Descripción completa

Detalles Bibliográficos
Autores: Fierros-Zárate, Geny del Socorro, Bermudez Morales, Victor, Madrid Marina, Vicente, Olvera, Clarita
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:México
Institución:Instituto Nacional de Salud Pública
Repositorio:Repositorio Institucional Abierto de Conocimiento en Salud Pública
Idioma:español
OAI Identifier:oai:repositorio.insp.mx:20.500.12096/8230
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330701/pdf/jcav11p4754.pdf
https://www.doi.org/ 10.7150/jca.33527
http://repositorio.insp.mx:8080/jspui/handle/20.500.12096/8230
Access Level:acceso abierto
Palabra clave:s,d,BMK-16,myc; IFN-τ; signal transducer; tumor cells; type 1 interferon.
info:eu-repo/classification/cti/3
id MX_a7e7f2bd41a2b193cd0fdb4e9a7f31cf
oai_identifier_str oai:repositorio.insp.mx:20.500.12096/8230
network_acronym_str MX
network_name_str México
repository_id_str
spelling Bovine Interferon-Tau Activates Type I interferon-Associated Janus-signal Transducer in HPV16-positive Tumor CellFierros-Zárate, Geny del SocorroBermudez Morales, VictorMadrid Marina, VicenteOlvera, Claritas,d,BMK-16,myc; IFN-τ; signal transducer; tumor cells; type 1 interferon.info:eu-repo/classification/cti/3Abstract The mechanisms of signal transduction by interferon-tau (IFN-τ) are widely known during the gestation of ruminants. In trophoblast cells, IFN-τ involves the activation of the JAK-STAT pathway, and it can have effects on other cell types, such as tumor cells. Here we report that the HPV16-positive BMK-16/myc cell treated with ovine IFN-τ, results in the activation of the canonical JAK-STAT and non-canonical JAK-STAT pathway. The MAPK signaling pathway was activated, we detected the proteins MEK1, MEK2, Raf1, STAT3, STA4, STAT5 and STAT6. Moreover, IFN-τ induced the expression of MHC Class I, MX and IP10 in the tumor cells and this response may be associated with the viral replication and with the anti-proliferative and the immunoregulatory effects of IFN-τ.ESPM INSP2023-05-25T14:21:31Z2023-05-25T14:21:31Z2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionpdfsicabi.insp.mx:2020-Nonehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330701/pdf/jcav11p4754.pdfhttps://www.doi.org/ 10.7150/jca.33527http://repositorio.insp.mx:8080/jspui/handle/20.500.12096/8230reponame:Repositorio Institucional Abierto de Conocimiento en Salud Públicainstname:Instituto Nacional de Salud Públicainstacron:INSPspanacionalinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0oai:repositorio.insp.mx:20.500.12096/82302024-08-27T22:04:31Z
dc.title.none.fl_str_mv Bovine Interferon-Tau Activates Type I interferon-Associated Janus-signal Transducer in HPV16-positive Tumor Cell
title Bovine Interferon-Tau Activates Type I interferon-Associated Janus-signal Transducer in HPV16-positive Tumor Cell
spellingShingle Bovine Interferon-Tau Activates Type I interferon-Associated Janus-signal Transducer in HPV16-positive Tumor Cell
Fierros-Zárate, Geny del Socorro
s,d,BMK-16,myc; IFN-τ; signal transducer; tumor cells; type 1 interferon.
info:eu-repo/classification/cti/3
title_short Bovine Interferon-Tau Activates Type I interferon-Associated Janus-signal Transducer in HPV16-positive Tumor Cell
title_full Bovine Interferon-Tau Activates Type I interferon-Associated Janus-signal Transducer in HPV16-positive Tumor Cell
title_fullStr Bovine Interferon-Tau Activates Type I interferon-Associated Janus-signal Transducer in HPV16-positive Tumor Cell
title_full_unstemmed Bovine Interferon-Tau Activates Type I interferon-Associated Janus-signal Transducer in HPV16-positive Tumor Cell
title_sort Bovine Interferon-Tau Activates Type I interferon-Associated Janus-signal Transducer in HPV16-positive Tumor Cell
dc.creator.none.fl_str_mv Fierros-Zárate, Geny del Socorro
Bermudez Morales, Victor
Madrid Marina, Vicente
Olvera, Clarita
author Fierros-Zárate, Geny del Socorro
author_facet Fierros-Zárate, Geny del Socorro
Bermudez Morales, Victor
Madrid Marina, Vicente
Olvera, Clarita
author_role author
author2 Bermudez Morales, Victor
Madrid Marina, Vicente
Olvera, Clarita
author2_role author
author
author
dc.subject.none.fl_str_mv s,d,BMK-16,myc; IFN-τ; signal transducer; tumor cells; type 1 interferon.
info:eu-repo/classification/cti/3
topic s,d,BMK-16,myc; IFN-τ; signal transducer; tumor cells; type 1 interferon.
info:eu-repo/classification/cti/3
description Abstract The mechanisms of signal transduction by interferon-tau (IFN-τ) are widely known during the gestation of ruminants. In trophoblast cells, IFN-τ involves the activation of the JAK-STAT pathway, and it can have effects on other cell types, such as tumor cells. Here we report that the HPV16-positive BMK-16/myc cell treated with ovine IFN-τ, results in the activation of the canonical JAK-STAT and non-canonical JAK-STAT pathway. The MAPK signaling pathway was activated, we detected the proteins MEK1, MEK2, Raf1, STAT3, STA4, STAT5 and STAT6. Moreover, IFN-τ induced the expression of MHC Class I, MX and IP10 in the tumor cells and this response may be associated with the viral replication and with the anti-proliferative and the immunoregulatory effects of IFN-τ.
publishDate 2020
dc.date.none.fl_str_mv 2020
2023-05-25T14:21:31Z
2023-05-25T14:21:31Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv sicabi.insp.mx:2020-None
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330701/pdf/jcav11p4754.pdf
https://www.doi.org/ 10.7150/jca.33527
http://repositorio.insp.mx:8080/jspui/handle/20.500.12096/8230
identifier_str_mv sicabi.insp.mx:2020-None
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330701/pdf/jcav11p4754.pdf
https://www.doi.org/ 10.7150/jca.33527
http://repositorio.insp.mx:8080/jspui/handle/20.500.12096/8230
dc.language.none.fl_str_mv spa
language spa
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0
dc.format.none.fl_str_mv pdf
dc.coverage.none.fl_str_mv nacional
dc.publisher.none.fl_str_mv ESPM INSP
publisher.none.fl_str_mv ESPM INSP
dc.source.none.fl_str_mv reponame:Repositorio Institucional Abierto de Conocimiento en Salud Pública
instname:Instituto Nacional de Salud Pública
instacron:INSP
instname_str Instituto Nacional de Salud Pública
instacron_str INSP
institution INSP
reponame_str Repositorio Institucional Abierto de Conocimiento en Salud Pública
collection Repositorio Institucional Abierto de Conocimiento en Salud Pública
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1858176453602967553
score 15.811543

Similares en LA Referencia