Bovine Interferon-Tau Activates Type I interferon-Associated Janus-signal Transducer in HPV16-positive Tumor Cell
Abstract The mechanisms of signal transduction by interferon-tau (IFN-τ) are widely known during the gestation of ruminants. In trophoblast cells, IFN-τ involves the activation of the JAK-STAT pathway, and it can have effects on other cell types, such as tumor cells. Here we report that the HPV16-po...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2020 |
| País: | México |
| Institución: | Instituto Nacional de Salud Pública |
| Repositorio: | Repositorio Institucional Abierto de Conocimiento en Salud Pública |
| Idioma: | español |
| OAI Identifier: | oai:repositorio.insp.mx:20.500.12096/8230 |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330701/pdf/jcav11p4754.pdf https://www.doi.org/ 10.7150/jca.33527 http://repositorio.insp.mx:8080/jspui/handle/20.500.12096/8230 |
| Access Level: | acceso abierto |
| Palabra clave: | s,d,BMK-16,myc; IFN-τ; signal transducer; tumor cells; type 1 interferon. info:eu-repo/classification/cti/3 |
| Sumario: | Abstract The mechanisms of signal transduction by interferon-tau (IFN-τ) are widely known during the gestation of ruminants. In trophoblast cells, IFN-τ involves the activation of the JAK-STAT pathway, and it can have effects on other cell types, such as tumor cells. Here we report that the HPV16-positive BMK-16/myc cell treated with ovine IFN-τ, results in the activation of the canonical JAK-STAT and non-canonical JAK-STAT pathway. The MAPK signaling pathway was activated, we detected the proteins MEK1, MEK2, Raf1, STAT3, STA4, STAT5 and STAT6. Moreover, IFN-τ induced the expression of MHC Class I, MX and IP10 in the tumor cells and this response may be associated with the viral replication and with the anti-proliferative and the immunoregulatory effects of IFN-τ. |
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