Synthesis, Characterization, and In Vitro and In Vivo Evaluations of cellulose hydrogels enriched with larrea tridentata for regenerative applications

Introduction. Tissue engineering is an elementary necessity for several applications in the biomedical field through the use of several biopolymers derived from plants. Larrea tridentata (LT) is a very used plant for various medicinal applications with interesting properties; however, its use into c...

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Autores: Rosa Saucedo, Judith Ríos Arana, Dalia Abril Guzmán-Gastélum, Beatriz Araceli Díaz Torres, Leon Espinosa_Cristobal, Juan Carlos Cuevas-González, Genaro Tamayo, Salvador David Nava Martinez, karla tovar
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:México
Institución:Universidad Autónoma de Ciudad Juárez
Repositorio:Repositorio Institucional de la Universidad Autónoma de Ciudad Juárez
OAI Identifier:oai:uacj.mx:oai:cathi.uacj.mx:20.500.11961ir-11532
Acceso en línea:https://doi.org/10.1155/2020/1425402
Access Level:acceso abierto
Palabra clave:Regenerative Applications
Larrea tridentata
Cellulose Hydrogels
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spelling Synthesis, Characterization, and In Vitro and In Vivo Evaluations of cellulose hydrogels enriched with larrea tridentata for regenerative applicationsRosa SaucedoJudith Ríos AranaDalia Abril Guzmán-GastélumBeatriz Araceli Díaz TorresLeon Espinosa_CristobalJuan Carlos Cuevas-GonzálezGenaro TamayoSalvador David Nava Martinezkarla tovarRegenerative ApplicationsLarrea tridentataCellulose Hydrogelsinfo:eu-repo/classification/cti/3Introduction. Tissue engineering is an elementary necessity for several applications in the biomedical field through the use of several biopolymers derived from plants. Larrea tridentata (LT) is a very used plant for various medicinal applications with interesting properties; however, its use into cellulose hydrogels for possible regenerative therapeutics is still limited. Cellulose films could be applied in medical field as wound healing, scaffold for connective tissue for periodontal applications, and so on. The aim of this study was to evaluate the mechanical properties and in vivo and in vitro biocompatibility of cellulose hydrogels that have been enriched with LT in a rat model. Methods. By in vivo and in vitro assays, the concentration of LT was varied from 1 to 5 wt%, respectively. Hydrogel films were implanted intramuscularly into female Wistar rats, 250 g in weight and aged 2 months, to analyze their cytocompatibility and biocompatibility. Results. No case showed any evidence of inflammation or toxicity. Regarding cell morphology and adhesion, the prepared LT cellulose films had better cytocompatibility values than when polystyrene (PS) dishes were used as the control. In all cases, the results suggest that the addition of LT to the hydrogel films did not affect their cytocompatibility or biocompatibility properties and increases their clinical application due to the reported uses of LT. Conclusions. Cellulose hydrogel films enriched with LT have the potential to be used in the biomedical field acting as regenerative scaffoldsRosa Alicia Saucedo AcuñaJudith Virginia Rios AranaDalia Abril Guzmán-GastélumBeatriz Araceli Diaz TorresLeon Francisco Espinosa CristobalJuan Carlos Cuevas-GonzálezGenaro TamayoSalvador David Nava Martinez2020info:eu-repo/semantics/articleArtículoinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.1155/2020/1425402reponame:Repositorio Institucional de la Universidad Autónoma de Ciudad Juárezinstname:Universidad Autónoma de Ciudad Juárezinstacron:UACJen_USinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc/4.0oai:uacj.mx:oai:cathi.uacj.mx:20.500.11961ir-115322025-11-26T19:46:52Z
dc.title.none.fl_str_mv Synthesis, Characterization, and In Vitro and In Vivo Evaluations of cellulose hydrogels enriched with larrea tridentata for regenerative applications
title Synthesis, Characterization, and In Vitro and In Vivo Evaluations of cellulose hydrogels enriched with larrea tridentata for regenerative applications
spellingShingle Synthesis, Characterization, and In Vitro and In Vivo Evaluations of cellulose hydrogels enriched with larrea tridentata for regenerative applications
Rosa Saucedo
Regenerative Applications
Larrea tridentata
Cellulose Hydrogels
info:eu-repo/classification/cti/3
title_short Synthesis, Characterization, and In Vitro and In Vivo Evaluations of cellulose hydrogels enriched with larrea tridentata for regenerative applications
title_full Synthesis, Characterization, and In Vitro and In Vivo Evaluations of cellulose hydrogels enriched with larrea tridentata for regenerative applications
title_fullStr Synthesis, Characterization, and In Vitro and In Vivo Evaluations of cellulose hydrogels enriched with larrea tridentata for regenerative applications
title_full_unstemmed Synthesis, Characterization, and In Vitro and In Vivo Evaluations of cellulose hydrogels enriched with larrea tridentata for regenerative applications
title_sort Synthesis, Characterization, and In Vitro and In Vivo Evaluations of cellulose hydrogels enriched with larrea tridentata for regenerative applications
dc.creator.none.fl_str_mv Rosa Saucedo
Judith Ríos Arana
Dalia Abril Guzmán-Gastélum
Beatriz Araceli Díaz Torres
Leon Espinosa_Cristobal
Juan Carlos Cuevas-González
Genaro Tamayo
Salvador David Nava Martinez
karla tovar
author Rosa Saucedo
author_facet Rosa Saucedo
Judith Ríos Arana
Dalia Abril Guzmán-Gastélum
Beatriz Araceli Díaz Torres
Leon Espinosa_Cristobal
Juan Carlos Cuevas-González
Genaro Tamayo
Salvador David Nava Martinez
karla tovar
author_role author
author2 Judith Ríos Arana
Dalia Abril Guzmán-Gastélum
Beatriz Araceli Díaz Torres
Leon Espinosa_Cristobal
Juan Carlos Cuevas-González
Genaro Tamayo
Salvador David Nava Martinez
karla tovar
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Rosa Alicia Saucedo Acuña
Judith Virginia Rios Arana
Dalia Abril Guzmán-Gastélum
Beatriz Araceli Diaz Torres
Leon Francisco Espinosa Cristobal
Juan Carlos Cuevas-González
Genaro Tamayo
Salvador David Nava Martinez
dc.subject.none.fl_str_mv Regenerative Applications
Larrea tridentata
Cellulose Hydrogels
info:eu-repo/classification/cti/3
topic Regenerative Applications
Larrea tridentata
Cellulose Hydrogels
info:eu-repo/classification/cti/3
description Introduction. Tissue engineering is an elementary necessity for several applications in the biomedical field through the use of several biopolymers derived from plants. Larrea tridentata (LT) is a very used plant for various medicinal applications with interesting properties; however, its use into cellulose hydrogels for possible regenerative therapeutics is still limited. Cellulose films could be applied in medical field as wound healing, scaffold for connective tissue for periodontal applications, and so on. The aim of this study was to evaluate the mechanical properties and in vivo and in vitro biocompatibility of cellulose hydrogels that have been enriched with LT in a rat model. Methods. By in vivo and in vitro assays, the concentration of LT was varied from 1 to 5 wt%, respectively. Hydrogel films were implanted intramuscularly into female Wistar rats, 250 g in weight and aged 2 months, to analyze their cytocompatibility and biocompatibility. Results. No case showed any evidence of inflammation or toxicity. Regarding cell morphology and adhesion, the prepared LT cellulose films had better cytocompatibility values than when polystyrene (PS) dishes were used as the control. In all cases, the results suggest that the addition of LT to the hydrogel films did not affect their cytocompatibility or biocompatibility properties and increases their clinical application due to the reported uses of LT. Conclusions. Cellulose hydrogel films enriched with LT have the potential to be used in the biomedical field acting as regenerative scaffolds
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
Artículo
info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1155/2020/1425402
url https://doi.org/10.1155/2020/1425402
dc.language.none.fl_str_mv en_US
language_invalid_str_mv en_US
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc/4.0
dc.source.none.fl_str_mv reponame:Repositorio Institucional de la Universidad Autónoma de Ciudad Juárez
instname:Universidad Autónoma de Ciudad Juárez
instacron:UACJ
instname_str Universidad Autónoma de Ciudad Juárez
instacron_str UACJ
institution UACJ
reponame_str Repositorio Institucional de la Universidad Autónoma de Ciudad Juárez
collection Repositorio Institucional de la Universidad Autónoma de Ciudad Juárez
repository.name.fl_str_mv
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