Evaluación de polimorfismos en genes relacionados con la inflamación en pacientes mexicanos con epilepsia
Epilepsy is the most common neurological disease and approximately 30% of patients who suffer from it do not respond to drug treatment, that is, they present drug-resistant epilepsy. Temporal lobe epilepsy (TLE) is the most frequent form of focal epilepsy in adults and the majority of patients with...
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| Tipo de recurso: | tesis de maestría |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | México |
| Institución: | Universidad Autónoma Metropolitana |
| Repositorio: | Repositorio Institucional de la UAM Iztapalapa |
| Idioma: | español |
| OAI Identifier: | oai:bindani.izt.uam.mx:1v53jx05d |
| Acceso en línea: | https://doi.org/10.24275/uami.1v53jx05d |
| Access Level: | acceso abierto |
| Palabra clave: | info:eu-repo/classification/LEM/Biología experimental info:eu-repo/classification/LEM/Epilepsia info:eu-repo/classification/LEM/Biology, Experimental info:eu-repo/classification/LEM/Polimorfismo (Genética) info:eu-repo/classification/LEM/Genetic polymorphisms info:eu-repo/classification/LEM/Epilepsy Evaluation info:eu-repo/classification/cti/2 |
| Sumario: | Epilepsy is the most common neurological disease and approximately 30% of patients who suffer from it do not respond to drug treatment, that is, they present drug-resistant epilepsy. Temporal lobe epilepsy (TLE) is the most frequent form of focal epilepsy in adults and the majority of patients with TLE hippocampal sclerosis (HS) is also present. On the other hand, it is estimated that the incidence of seizures in patients with brain tumors (EPT) varies between 30% and 100%. Several studies suggest that there is a positive feedback loop between epileptogenesis and brain inflammation. Similarly, it is known that inflammation can be modulated by apolipoprotein E (ApoE). In Mexico, there are few articles estimating the influence of genetic factors and neuroinflammation in the course of epilepsy. For this reason, in this study, some variants present in PTGS2, CR1, CRP, TNF-α, IL-1, IL-1, IL-6, IL-10, and ApoE genes were evaluated in Mexican patients with refractory TLE with and without HS, and EPT. The following associations were identified: a) G/G and G/G genotypes of the variants rs1800795 (IL6) and rs20417 (PTGS2), respectively, with EPT. b) The G/G genotype of rs1799724 (TNF-α) with HS. c) The genotype C/G (rs1800947) and G/G (rs20417) located in CRP and PTGS2, respectively, with TLE. Finally, it was observed that the combination of the ε4 ApoE allele with the G/G genotype (rs1800795) of IL-6 and G/G (rs20417) of PTGS2 is associated with TLE. These results present possible genetic markers associated with inflammation for TLE, HS and EPT. |
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