STEREOCHEMICAL ANALYSIS OFN-CYCLOHEXYLIDENE-N-(1-PHENYLETHYL) AMINE DERIVATIVES
Imines are important intermediates which have been usedin deracemizing alkylation, acylation, lactams and oxaziri-dine preparations as well as in Michael additions. Iminiumsalts have also been proposed as intermediates in the prepa-ration of amines obtained by reductive amination of ketoneswith redu...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2005 |
| País: | México |
| Institución: | Universidad Autónoma de Nayarit |
| Repositorio: | Repositorio Institucional Aramara de la UAN |
| Idioma: | inglés |
| OAI Identifier: | oai:dspace.uan.mx:123456789/1966 |
| Acceso en línea: | https://doi.org/10.1002/mrc.1666 http://dspace.uan.mx:8080/jspui/handle/123456789/1966 |
| Access Level: | acceso abierto |
| Palabra clave: | 1HNMR 13CNMR 15N NMR configuración N-ciclohexilideno-1-feniletilamina derivativa configuration N-cyclohexylidene-1-phenylethylamine derivativ MEDICINA Y CIENCIAS DE LA SALUD [3] |
| Sumario: | Imines are important intermediates which have been usedin deracemizing alkylation, acylation, lactams and oxaziri-dine preparations as well as in Michael additions. Iminiumsalts have also been proposed as intermediates in the prepa-ration of amines obtained by reductive amination of ketoneswith reducing agents, but this intermediate has never beendetected nor isolated. Eventhough imines have been widelyused for the last 20 years their structures have not beencompletely analyzed by means of spectroscopic methods.To our knowledge, only the absolute configurations ofN-cyclohexylidene-1-phenylethylamine (1)andsomeisomersofN-(2-methylcyclohexylidene)-1-phenylethylamine (2)pre-pared by stereoselective alkylation, have been determinedby means of chiroptical methods and their relative configuration established by NMR. |
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