DETERMINATION OF THE CONFORMATIONSAND RELATIVE CONFIGURATIONS OF EXOCYCLIC AMINES
Knowledge of the absolute configuration and conformationof exocyclic amines is of great importance, particularly for compounds with biological activity. Also, determination ofthe stereoselectivity of a reaction is important for both the pharmaceutical and agricultural industries. The exocyclic amine...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2010 |
| País: | México |
| Institución: | Universidad Autónoma de Nayarit |
| Repositorio: | Repositorio Institucional Aramara de la UAN |
| Idioma: | inglés |
| OAI Identifier: | oai:dspace.uan.mx:123456789/1965 |
| Acceso en línea: | https://doi.org/10.1002/mrc.2693 http://dspace.uan.mx:8080/jspui/handle/123456789/1965 |
| Access Level: | acceso abierto |
| Palabra clave: | 1H 13C 15N RMN conformación configuración amina exocíclica conformation configuration exocyclic amine MEDICINA Y CIENCIAS DE LA SALUD [3] |
| Sumario: | Knowledge of the absolute configuration and conformationof exocyclic amines is of great importance, particularly for compounds with biological activity. Also, determination ofthe stereoselectivity of a reaction is important for both the pharmaceutical and agricultural industries. The exocyclic amines are a key group of compounds because they are the source of many interesting substances in these industries. Some of the amines reported here have been used as chiral inductors, particularly the derivatives of 1-phenylethylamine and 1-(naphthalen-2-yl) ethylamine. The cyclohexanamines and their N-substituted derivatives form a group of secondary amines with a variety of basicities that can be used in the synthesis of complex molecules; currently, N-(propan-2-yl) cyclohexanamine is used as a base for the deprotonation of slightly acidic compounds through the preparation of a lithium amide. |
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