Cytotoxic constituents from the stem bark of Alvaradoa Amorphoides
The chemical study of Alvaradoa amorphoides led to the isolation of four major constituents: chrysophanol (1), β-sitosterol (2), atraric acid (3), and 17-octadecen-6-ynoic acid (4). All compounds were evaluated on in vitro cytotoxic and antiproliferative assays. Atraric acid and 17-octadecen-6-ynoic...
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2015 |
| País: | México |
| Recursos: | Centro de Investigación Científica de Yucatán |
| Repositorio: | Repositorio Institucional CICY |
| Idioma: | inglés |
| OAI Identifier: | oai:cicy.repositorioinstitucional.mx:1003/515 |
| Acesso em linha: | http://cicy.repositorioinstitucional.mx/jspui/handle/1003/515 |
| Access Level: | acceso abierto |
| Palavra-chave: | info:eu-repo/classification/Autores/ALVARADOA AMORPHOIDES info:eu-repo/classification/Autores/CYTOTOXIC ACTIVITY info:eu-repo/classification/Autores/ANTIPROLIFERATIVE ACTIVITY info:eu-repo/classification/Autores/ACETYLENIC COMPOUND info:eu-repo/classification/cti/2 |
| Resumo: | The chemical study of Alvaradoa amorphoides led to the isolation of four major constituents: chrysophanol (1), β-sitosterol (2), atraric acid (3), and 17-octadecen-6-ynoic acid (4). All compounds were evaluated on in vitro cytotoxic and antiproliferative assays. Atraric acid and 17-octadecen-6-ynoic acid showed cytotoxic activity. Additionally, compound 4 exhibited cytotoxic activity showing a certain degree of selectivity against cancer cell lines. |
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