Cytotoxic Constituents from the Stem Bark of Alvaradoa amorphoides
The chemical study of Alvaradoa amorphoides led to the isolation of four major constituents: chrysophanol (1), β-sitosterol (2), atraric acid (3), and 17-octadecen-6-ynoic acid (4). All compounds were evaluated on in vitro cytotoxic and antiproliferative assays. Atraric acid and 17-octadecen-6-ynoic...
| Autores: | , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2015 |
| País: | México |
| Recursos: | Instituto Mexicano del Seguro Social |
| Repositorio: | Redalyc-IMSS |
| OAI Identifier: | oai:redalyc.org:47543190006 |
| Acesso em linha: | https://www.redalyc.org/articulo.oa?id=47543190006 |
| Access Level: | acceso abierto |
| Palavra-chave: | Química cytotoxic activity acetylenic compound Alvaradoa amorphoides antiproliferative activity |
| Resumo: | The chemical study of Alvaradoa amorphoides led to the isolation of four major constituents: chrysophanol (1), β-sitosterol (2), atraric acid (3), and 17-octadecen-6-ynoic acid (4). All compounds were evaluated on in vitro cytotoxic and antiproliferative assays. Atraric acid and 17-octadecen-6-ynoic acid showed cytotoxic activity. Additionally, compound 4 exhibited cytotoxic activity showing a certain degree of selectivity against cancer cell lines. |
|---|