Effect of Formulation Variables on Verapamil hydrochloride release from hydrated HPMC matrices

Among different variables that influence drug release fromhydrated hydrophilic matrices, the polymer proportion, the drug doseand the matrix pH can be included. In a first approach to formulate atransdermal drug delivery system, these variables have been used tomodify the drug release rate and to ex...

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Detalhes bibliográficos
Autores: Marcela Ramírez Campos, Leopoldo Villafuerte Robles
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2004
País:México
Recursos:Instituto Politécnico Nacional
Repositorio:Redalyc-IPN
OAI Identifier:oai:redalyc.org:47548423
Acesso em linha:https://www.redalyc.org/articulo.oa?id=47548423
Access Level:acceso abierto
Palavra-chave:Multidisciplinaria (Ciencias Naturales y Exactas)
pH
HPMC
verapamil
transdermal delivery
words: Sustained release
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spelling Effect of Formulation Variables on Verapamil hydrochloride release from hydrated HPMC matricesMarcela Ramírez CamposLeopoldo Villafuerte RoblesMultidisciplinaria (Ciencias Naturales y Exactas)pHHPMCverapamiltransdermal deliverywords: Sustained releaseAmong different variables that influence drug release fromhydrated hydrophilic matrices, the polymer proportion, the drug doseand the matrix pH can be included. In a first approach to formulate atransdermal drug delivery system, these variables have been used tomodify the drug release rate and to examine its effect on the releasemechanism. Hydrated matrices were prepared varying the matrix proportionof hydroxypropyl methylcellulose (HPMC), the pH and theamount of verapamil hydrochloride loaded. The matrices releasebehavior (USP 23 apparatus 5, paddle over disk method, at 150 rpm)was examined using 900 mL of an aqueous solution of NaCl (0.9%)as dissolution medium. The increase of the HPMC matrix proportionreduced the release rate of the drug. The release profiles showed zeroorder kinetics for drug dissolution proportions up to 70%. Theincrease of the matrix drug load increases slightly the release rate.The increase of the matrix pH from 5.0 to 8.0 increased the releaserate. The effect of both pH and drug load becomes lesser as thematrix polymer proportion increases from 5% to 15% w/w. The useof a Collodion membrane covering the hydrated matrices decreasestwo orders of magnitude the release rate of verapamil hydrochloride.Sociedad Química de México2004info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdf1870-249Xhttps://www.redalyc.org/articulo.oa?id=47548423Journal of the Mexican Chemical Society (México) Num.4 Vol.48reponame:Redalyc-IPNinstname:Instituto Politécnico Nacionalinstacron:IPNenhttp://www.redalyc.org/revista.oa?id=475Journal of the Mexican Chemical Societyinfo:eu-repo/semantics/openAccessoai:redalyc.org:475484232026-01-29T02:55:00Z
dc.title.none.fl_str_mv Effect of Formulation Variables on Verapamil hydrochloride release from hydrated HPMC matrices
title Effect of Formulation Variables on Verapamil hydrochloride release from hydrated HPMC matrices
spellingShingle Effect of Formulation Variables on Verapamil hydrochloride release from hydrated HPMC matrices
Marcela Ramírez Campos
Multidisciplinaria (Ciencias Naturales y Exactas)
pH
HPMC
verapamil
transdermal delivery
words: Sustained release
title_short Effect of Formulation Variables on Verapamil hydrochloride release from hydrated HPMC matrices
title_full Effect of Formulation Variables on Verapamil hydrochloride release from hydrated HPMC matrices
title_fullStr Effect of Formulation Variables on Verapamil hydrochloride release from hydrated HPMC matrices
title_full_unstemmed Effect of Formulation Variables on Verapamil hydrochloride release from hydrated HPMC matrices
title_sort Effect of Formulation Variables on Verapamil hydrochloride release from hydrated HPMC matrices
dc.creator.none.fl_str_mv Marcela Ramírez Campos
Leopoldo Villafuerte Robles
author Marcela Ramírez Campos
author_facet Marcela Ramírez Campos
Leopoldo Villafuerte Robles
author_role author
author2 Leopoldo Villafuerte Robles
author2_role author
dc.subject.none.fl_str_mv Multidisciplinaria (Ciencias Naturales y Exactas)
pH
HPMC
verapamil
transdermal delivery
words: Sustained release
topic Multidisciplinaria (Ciencias Naturales y Exactas)
pH
HPMC
verapamil
transdermal delivery
words: Sustained release
description Among different variables that influence drug release fromhydrated hydrophilic matrices, the polymer proportion, the drug doseand the matrix pH can be included. In a first approach to formulate atransdermal drug delivery system, these variables have been used tomodify the drug release rate and to examine its effect on the releasemechanism. Hydrated matrices were prepared varying the matrix proportionof hydroxypropyl methylcellulose (HPMC), the pH and theamount of verapamil hydrochloride loaded. The matrices releasebehavior (USP 23 apparatus 5, paddle over disk method, at 150 rpm)was examined using 900 mL of an aqueous solution of NaCl (0.9%)as dissolution medium. The increase of the HPMC matrix proportionreduced the release rate of the drug. The release profiles showed zeroorder kinetics for drug dissolution proportions up to 70%. Theincrease of the matrix drug load increases slightly the release rate.The increase of the matrix pH from 5.0 to 8.0 increased the releaserate. The effect of both pH and drug load becomes lesser as thematrix polymer proportion increases from 5% to 15% w/w. The useof a Collodion membrane covering the hydrated matrices decreasestwo orders of magnitude the release rate of verapamil hydrochloride.
publishDate 2004
dc.date.none.fl_str_mv 2004
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 1870-249X
https://www.redalyc.org/articulo.oa?id=47548423
identifier_str_mv 1870-249X
url https://www.redalyc.org/articulo.oa?id=47548423
dc.language.none.fl_str_mv en
language_invalid_str_mv en
dc.relation.none.fl_str_mv http://www.redalyc.org/revista.oa?id=475
dc.rights.none.fl_str_mv Journal of the Mexican Chemical Society
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Journal of the Mexican Chemical Society
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedad Química de México
publisher.none.fl_str_mv Sociedad Química de México
dc.source.none.fl_str_mv Journal of the Mexican Chemical Society (México) Num.4 Vol.48
reponame:Redalyc-IPN
instname:Instituto Politécnico Nacional
instacron:IPN
instname_str Instituto Politécnico Nacional
instacron_str IPN
institution IPN
reponame_str Redalyc-IPN
collection Redalyc-IPN
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 14,965156

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