Assessment of a modified release verapamil.HCl matrix compacts : Effect of formulation composition on the in-vitro release kinetic
ABSTRACT: Verapamil hydrochloride is a drug used to treat arrhythmias. In this study, a D-optimal mixture design with 16 runs was used to select the best combination of three polymers into a matrix that rendered an 8 h in vitro release profile of verapamil. hydrochloride (HCl) which fulfill a once-a...
| Authors: | , , |
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| Format: | article |
| Status: | Published version |
| Publication Date: | 2013 |
| Country: | Colombia |
| Institution: | Universidad de Antioquia |
| Repository: | Repositorio UdeA |
| Language: | English |
| OAI Identifier: | oai:bibliotecadigital.udea.edu.co:10495/25207 |
| Online Access: | http://hdl.handle.net/10495/25207 |
| Access Level: | Open access |
| Keyword: | Verapamilo Verapamil Dinámicas no Lineales Nonlinear Dynamics Diseño experimental Experimental design Controlled-release preparations |
| Summary: | ABSTRACT: Verapamil hydrochloride is a drug used to treat arrhythmias. In this study, a D-optimal mixture design with 16 runs was used to select the best combination of three polymers into a matrix that rendered an 8 h in vitro release profile of verapamil. hydrochloride (HCl) which fulfill a once-a-day modified release in compliance with the United States Pharmacopeia (USP) specifications. The Korsmeyer-Peppas model was used to fit the dissolution data since it presented the best fitting characteristics. A cubic model predicted the best formulation of verapamil.HCl containing carnauba wax, hydroxypropyl methyl cellulose and Avicel_PH101 at the 40, 20 and 40% levels, respectively. Validation runs confirmed the accuracy of the cubic models which include these three components. |
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