CagL polymorphisms D58/K59 are predominant in Helicobacter pylori strains isolated from Mexican patients with chronic gastritis.

Helicobacter pylori is a Gram¿negative bacterium that colonizes the gastric mucosa in humans. One of the main virulence factors of H. pylori is the cag pathogenicity island (cagPAI), which encodes a type 4¿secretion system (T4SS) and the cytotoxin CagA. Translocation of CagA through the T4SS trigger...

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Autores: Roman Roman, Adolfo, Martinez Santos, Veronica Iranzu, Castañon Sanchez, Carlos Alberto, Albañil Muñoz, Alan J, González Mendoza, Paola, Soto¿Flores, Diana G, Martinez Carrillo, Dinorah Nashely, Fernandez Tilapa, Gloria
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:México
Institución:Universidad Autónoma de Guerrero
Repositorio:Repositorio Institucional de Ciencia Abierta de la Universidad Autónoma de Guerrero
Idioma:español
OAI Identifier:oai:ri.uagro.mx:uagro/1214
Acceso en línea:http://ri.uagro.mx/handle/uagro/1214
Access Level:acceso abierto
Palabra clave:Chronic gastritis
polymorphisms
Polymorphic
MEDICINA Y CIENCIAS DE LA SALUD::CIENCIAS MÉDICAS::OTRAS ESPECIALIDADES MÉDICAS
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network_acronym_str MX
network_name_str México
repository_id_str
spelling CagL polymorphisms D58/K59 are predominant in Helicobacter pylori strains isolated from Mexican patients with chronic gastritis.Roman Roman, AdolfoMartinez Santos, Veronica IranzuCastañon Sanchez, Carlos AlbertoAlbañil Muñoz, Alan JGonzález Mendoza, PaolaSoto¿Flores, Diana GMartinez Carrillo, Dinorah NashelyFernandez Tilapa, GloriaChronic gastritispolymorphismsPolymorphicMEDICINA Y CIENCIAS DE LA SALUD::CIENCIAS MÉDICAS::OTRAS ESPECIALIDADES MÉDICASHelicobacter pylori is a Gram¿negative bacterium that colonizes the gastric mucosa in humans. One of the main virulence factors of H. pylori is the cag pathogenicity island (cagPAI), which encodes a type 4¿secretion system (T4SS) and the cytotoxin CagA. Translocation of CagA through the T4SS triggers host¿signaling pathways. One of the T4SS proteins is CagL, which is necessary for CagA translocation. CagL is a 26¿kDa protein that contains a hypervariable motif, which spans residues 58 to 62. Several polymorphisms in this region have been associated with different disease outcomes, e.g. in Mexico, N58 is associated with a higher risk of gastric cancer. The aim of this work is to analyze the sequence of the hypervariable motif (residues 58 to 62) of clinical isolates from Mexican patients with chronic gastritis, and to correlate these polymorphisms with the vacA genotype.Gut Pathogens2020-04-21T02:28:38Z2020-04-21T02:28:38Z2019-02-13Artículoinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlepdfBorn digitalapplication/pdf1757-4749http://ri.uagro.mx/handle/uagro/12146211reponame:Repositorio Institucional de Ciencia Abierta de la Universidad Autónoma de Guerreroinstname:Universidad Autónoma de Guerreroinstacron:UAGROspahttp://creativecommons.org/licenses/by-nc-nd/4.0openAccessinfo:eu-repo/semantics/openAccessoai:ri.uagro.mx:uagro/12142024-08-28T00:00:42Z
dc.title.none.fl_str_mv CagL polymorphisms D58/K59 are predominant in Helicobacter pylori strains isolated from Mexican patients with chronic gastritis.
title CagL polymorphisms D58/K59 are predominant in Helicobacter pylori strains isolated from Mexican patients with chronic gastritis.
spellingShingle CagL polymorphisms D58/K59 are predominant in Helicobacter pylori strains isolated from Mexican patients with chronic gastritis.
Roman Roman, Adolfo
Chronic gastritis
polymorphisms
Polymorphic
MEDICINA Y CIENCIAS DE LA SALUD::CIENCIAS MÉDICAS::OTRAS ESPECIALIDADES MÉDICAS
title_short CagL polymorphisms D58/K59 are predominant in Helicobacter pylori strains isolated from Mexican patients with chronic gastritis.
title_full CagL polymorphisms D58/K59 are predominant in Helicobacter pylori strains isolated from Mexican patients with chronic gastritis.
title_fullStr CagL polymorphisms D58/K59 are predominant in Helicobacter pylori strains isolated from Mexican patients with chronic gastritis.
title_full_unstemmed CagL polymorphisms D58/K59 are predominant in Helicobacter pylori strains isolated from Mexican patients with chronic gastritis.
title_sort CagL polymorphisms D58/K59 are predominant in Helicobacter pylori strains isolated from Mexican patients with chronic gastritis.
dc.creator.none.fl_str_mv Roman Roman, Adolfo
Martinez Santos, Veronica Iranzu
Castañon Sanchez, Carlos Alberto
Albañil Muñoz, Alan J
González Mendoza, Paola
Soto¿Flores, Diana G
Martinez Carrillo, Dinorah Nashely
Fernandez Tilapa, Gloria
author Roman Roman, Adolfo
author_facet Roman Roman, Adolfo
Martinez Santos, Veronica Iranzu
Castañon Sanchez, Carlos Alberto
Albañil Muñoz, Alan J
González Mendoza, Paola
Soto¿Flores, Diana G
Martinez Carrillo, Dinorah Nashely
Fernandez Tilapa, Gloria
author_role author
author2 Martinez Santos, Veronica Iranzu
Castañon Sanchez, Carlos Alberto
Albañil Muñoz, Alan J
González Mendoza, Paola
Soto¿Flores, Diana G
Martinez Carrillo, Dinorah Nashely
Fernandez Tilapa, Gloria
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Chronic gastritis
polymorphisms
Polymorphic
MEDICINA Y CIENCIAS DE LA SALUD::CIENCIAS MÉDICAS::OTRAS ESPECIALIDADES MÉDICAS
topic Chronic gastritis
polymorphisms
Polymorphic
MEDICINA Y CIENCIAS DE LA SALUD::CIENCIAS MÉDICAS::OTRAS ESPECIALIDADES MÉDICAS
description Helicobacter pylori is a Gram¿negative bacterium that colonizes the gastric mucosa in humans. One of the main virulence factors of H. pylori is the cag pathogenicity island (cagPAI), which encodes a type 4¿secretion system (T4SS) and the cytotoxin CagA. Translocation of CagA through the T4SS triggers host¿signaling pathways. One of the T4SS proteins is CagL, which is necessary for CagA translocation. CagL is a 26¿kDa protein that contains a hypervariable motif, which spans residues 58 to 62. Several polymorphisms in this region have been associated with different disease outcomes, e.g. in Mexico, N58 is associated with a higher risk of gastric cancer. The aim of this work is to analyze the sequence of the hypervariable motif (residues 58 to 62) of clinical isolates from Mexican patients with chronic gastritis, and to correlate these polymorphisms with the vacA genotype.
publishDate 2019
dc.date.none.fl_str_mv 2019-02-13
2020-04-21T02:28:38Z
2020-04-21T02:28:38Z
dc.type.none.fl_str_mv Artículo
info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 1757-4749
http://ri.uagro.mx/handle/uagro/1214
6211
identifier_str_mv 1757-4749
6211
url http://ri.uagro.mx/handle/uagro/1214
dc.language.none.fl_str_mv spa
language spa
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0
openAccess
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0
openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv pdf
Born digital
application/pdf
dc.publisher.none.fl_str_mv Gut Pathogens
publisher.none.fl_str_mv Gut Pathogens
dc.source.none.fl_str_mv reponame:Repositorio Institucional de Ciencia Abierta de la Universidad Autónoma de Guerrero
instname:Universidad Autónoma de Guerrero
instacron:UAGRO
instname_str Universidad Autónoma de Guerrero
instacron_str UAGRO
institution UAGRO
reponame_str Repositorio Institucional de Ciencia Abierta de la Universidad Autónoma de Guerrero
collection Repositorio Institucional de Ciencia Abierta de la Universidad Autónoma de Guerrero
repository.name.fl_str_mv
repository.mail.fl_str_mv
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