CRISPR / CAS: the future of gene editing

Since the project of the human genome and the subsequent publication of the sequence of more than 20,000 genes that comprise it, the study of the genomes of many organisms and their editing have been a trend since then, being proposed and discovered new tools that allow the editing of DNA. CRISPR/Ca...

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Detalhes bibliográficos
Autores: Mayboca Padilla, Daniel, Flores Ruiz, Daniel
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2020
País:México
Recursos:UNIVERSIDAD DE SONORA
Repositório:Epistemus
Idioma:espanhol
OAI Identifier:oai:oai.epistemus.unison.mx:article/115
Acesso em linha:https://epistemus.unison.mx/index.php/epistemus/article/view/115
Access Level:Acceso aberto
Palavra-chave:CRISPR/Cas
Genomic editing tool
Gene therapy
Antiviral treatment
Edición genómica
Terapia génica
Tratamiento antiviral
Descrição
Resumo:Since the project of the human genome and the subsequent publication of the sequence of more than 20,000 genes that comprise it, the study of the genomes of many organisms and their editing have been a trend since then, being proposed and discovered new tools that allow the editing of DNA. CRISPR/Cas system whose natural function is a defense of bacteria against viral infections, ended up being a breakthrough in the field of genomic sciences, allowing genomic editing at a level of precision greater than the techniques that preceded it. The applications of this system that has been emphasized in recent years, are gene therapy and the Development of alternative antiviral treatments. Despite the advances of CRISPR/Cas, it is still required to increase its specificity to eliminate the appearance of mutations outside the target gene.