Balancing porosity and mechanical properties of titanium samples to favor cellular growth against bacteria

Two main problems limit the success of titanium implants: bacterial infection, which restricts their osseointegration capacity; and the stiffness mismatch between the implant and the host cortical bone, which promotes bone resorption and risk of fracture. Porosity incorporation may reduce this diffe...

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Autores: Ana Civantos Fernandez, Ana M Beltran, Cristina Domínguez Trujillo, Maria D. Garvi, Julian Lebrato, José A. Rodríguez-Ortiz, Francisco García-Moreno, JUAN VALERIO CAUICH RODRIGUEZ, Julio J. Guzman, Yadir Torres
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:México
Institución:Centro de Investigación Científica de Yucatán
Repositorio:Repositorio Institucional CICY
Idioma:inglés
OAI Identifier:oai:cicy.repositorioinstitucional.mx:1003/1691
Acceso en línea:http://cicy.repositorioinstitucional.mx/jspui/handle/1003/1691
Access Level:acceso abierto
Palabra clave:info:eu-repo/classification/Autores/BONE IMPLANT
info:eu-repo/classification/Autores/POROUS TITANIUM
info:eu-repo/classification/Autores/CELLULAR ADHESION
info:eu-repo/classification/Autores/BACTERIA COLONIZATION
info:eu-repo/classification/Autores/OSSEOINTEGRATION
info:eu-repo/classification/cti/7
info:eu-repo/classification/cti/33
info:eu-repo/classification/cti/3312
info:eu-repo/classification/cti/331208
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spelling Balancing porosity and mechanical properties of titanium samples to favor cellular growth against bacteriaAna Civantos FernandezAna M BeltranCristina Domínguez TrujilloMaria D. GarviJulian LebratoJosé A. Rodríguez-OrtizFrancisco García-MorenoJUAN VALERIO CAUICH RODRIGUEZJulio J. GuzmanYadir Torresinfo:eu-repo/classification/Autores/BONE IMPLANTinfo:eu-repo/classification/Autores/POROUS TITANIUMinfo:eu-repo/classification/Autores/CELLULAR ADHESIONinfo:eu-repo/classification/Autores/BACTERIA COLONIZATIONinfo:eu-repo/classification/Autores/OSSEOINTEGRATIONinfo:eu-repo/classification/cti/7info:eu-repo/classification/cti/33info:eu-repo/classification/cti/3312info:eu-repo/classification/cti/331208info:eu-repo/classification/cti/331208Two main problems limit the success of titanium implants: bacterial infection, which restricts their osseointegration capacity; and the stiffness mismatch between the implant and the host cortical bone, which promotes bone resorption and risk of fracture. Porosity incorporation may reduce this difference in stiffness but compromise biomechanical behavior. In this work, the relationship between the microstructure (content, size, and shape of pores) and the antibacterial and cellular behavior of samples fabricated by the space-holder technique (50 vol % NH4HCO3 and three ranges of particle sizes) is established. Results are discussed in terms of the best biomechanical properties and biofunctional activity balance (cell biocompatibility and antibacterial behavior). All substrates achieved suitable cell biocompatibility of premioblast and osteoblast in adhesion and proliferation processes. It is worth to highlighting that samples fabricated with the 100–200 μm space-holder present better mechanical behavior—in terms of stiffness, microhardness, and yield strength—which make them a very suitable material to replace cortical bone tissues. Those results exposed the relationship between the surface properties and the race of bacteria and mammalian cells for the surface with the aim to promote cellular growth over bacteria.2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://cicy.repositorioinstitucional.mx/jspui/handle/1003/1691Metals, 9(10), 1039, 2019reponame:Repositorio Institucional CICYinstname:Centro de Investigación Científica de Yucatáninstacron:CICYenginfo:eu-repo/semantics/datasetDOI/10.3390/met9101039info:eu-repo/semantics/altIdentifier/DOI/10.3390/met9101039citation:Civantos, A., Beltrán, A. M., Domínguez-Trujillo, C., Garvi, M. D., Lebrato, J., Rodríguez-Ortiz, J. A., ... & Torres, Y. (2019). Balancing porosity and mechanical properties of titanium samples to favor cellular growth against bacteria. Metals, 9(10), 1039.info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0oai:cicy.repositorioinstitucional.mx:1003/16912024-08-28T03:18:42Z
dc.title.none.fl_str_mv Balancing porosity and mechanical properties of titanium samples to favor cellular growth against bacteria
title Balancing porosity and mechanical properties of titanium samples to favor cellular growth against bacteria
spellingShingle Balancing porosity and mechanical properties of titanium samples to favor cellular growth against bacteria
Ana Civantos Fernandez
info:eu-repo/classification/Autores/BONE IMPLANT
info:eu-repo/classification/Autores/POROUS TITANIUM
info:eu-repo/classification/Autores/CELLULAR ADHESION
info:eu-repo/classification/Autores/BACTERIA COLONIZATION
info:eu-repo/classification/Autores/OSSEOINTEGRATION
info:eu-repo/classification/cti/7
info:eu-repo/classification/cti/33
info:eu-repo/classification/cti/3312
info:eu-repo/classification/cti/331208
info:eu-repo/classification/cti/331208
title_short Balancing porosity and mechanical properties of titanium samples to favor cellular growth against bacteria
title_full Balancing porosity and mechanical properties of titanium samples to favor cellular growth against bacteria
title_fullStr Balancing porosity and mechanical properties of titanium samples to favor cellular growth against bacteria
title_full_unstemmed Balancing porosity and mechanical properties of titanium samples to favor cellular growth against bacteria
title_sort Balancing porosity and mechanical properties of titanium samples to favor cellular growth against bacteria
dc.creator.none.fl_str_mv Ana Civantos Fernandez
Ana M Beltran
Cristina Domínguez Trujillo
Maria D. Garvi
Julian Lebrato
José A. Rodríguez-Ortiz
Francisco García-Moreno
JUAN VALERIO CAUICH RODRIGUEZ
Julio J. Guzman
Yadir Torres
author Ana Civantos Fernandez
author_facet Ana Civantos Fernandez
Ana M Beltran
Cristina Domínguez Trujillo
Maria D. Garvi
Julian Lebrato
José A. Rodríguez-Ortiz
Francisco García-Moreno
JUAN VALERIO CAUICH RODRIGUEZ
Julio J. Guzman
Yadir Torres
author_role author
author2 Ana M Beltran
Cristina Domínguez Trujillo
Maria D. Garvi
Julian Lebrato
José A. Rodríguez-Ortiz
Francisco García-Moreno
JUAN VALERIO CAUICH RODRIGUEZ
Julio J. Guzman
Yadir Torres
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv info:eu-repo/classification/Autores/BONE IMPLANT
info:eu-repo/classification/Autores/POROUS TITANIUM
info:eu-repo/classification/Autores/CELLULAR ADHESION
info:eu-repo/classification/Autores/BACTERIA COLONIZATION
info:eu-repo/classification/Autores/OSSEOINTEGRATION
info:eu-repo/classification/cti/7
info:eu-repo/classification/cti/33
info:eu-repo/classification/cti/3312
info:eu-repo/classification/cti/331208
info:eu-repo/classification/cti/331208
topic info:eu-repo/classification/Autores/BONE IMPLANT
info:eu-repo/classification/Autores/POROUS TITANIUM
info:eu-repo/classification/Autores/CELLULAR ADHESION
info:eu-repo/classification/Autores/BACTERIA COLONIZATION
info:eu-repo/classification/Autores/OSSEOINTEGRATION
info:eu-repo/classification/cti/7
info:eu-repo/classification/cti/33
info:eu-repo/classification/cti/3312
info:eu-repo/classification/cti/331208
info:eu-repo/classification/cti/331208
description Two main problems limit the success of titanium implants: bacterial infection, which restricts their osseointegration capacity; and the stiffness mismatch between the implant and the host cortical bone, which promotes bone resorption and risk of fracture. Porosity incorporation may reduce this difference in stiffness but compromise biomechanical behavior. In this work, the relationship between the microstructure (content, size, and shape of pores) and the antibacterial and cellular behavior of samples fabricated by the space-holder technique (50 vol % NH4HCO3 and three ranges of particle sizes) is established. Results are discussed in terms of the best biomechanical properties and biofunctional activity balance (cell biocompatibility and antibacterial behavior). All substrates achieved suitable cell biocompatibility of premioblast and osteoblast in adhesion and proliferation processes. It is worth to highlighting that samples fabricated with the 100–200 μm space-holder present better mechanical behavior—in terms of stiffness, microhardness, and yield strength—which make them a very suitable material to replace cortical bone tissues. Those results exposed the relationship between the surface properties and the race of bacteria and mammalian cells for the surface with the aim to promote cellular growth over bacteria.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://cicy.repositorioinstitucional.mx/jspui/handle/1003/1691
url http://cicy.repositorioinstitucional.mx/jspui/handle/1003/1691
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/datasetDOI/10.3390/met9101039
info:eu-repo/semantics/altIdentifier/DOI/10.3390/met9101039
citation:Civantos, A., Beltrán, A. M., Domínguez-Trujillo, C., Garvi, M. D., Lebrato, J., Rodríguez-Ortiz, J. A., ... & Torres, Y. (2019). Balancing porosity and mechanical properties of titanium samples to favor cellular growth against bacteria. Metals, 9(10), 1039.
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Metals, 9(10), 1039, 2019
reponame:Repositorio Institucional CICY
instname:Centro de Investigación Científica de Yucatán
instacron:CICY
instname_str Centro de Investigación Científica de Yucatán
instacron_str CICY
institution CICY
reponame_str Repositorio Institucional CICY
collection Repositorio Institucional CICY
repository.name.fl_str_mv
repository.mail.fl_str_mv
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